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Oncothyreon's PX-866 is effective in preclinical model of pulmonary fibrosis
Date:5/18/2009

SEATTLE, May 18 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY) (TSX: ONY) today announced the presentation of data demonstrating the effectiveness of Oncothyreon's PX-866 in a preclinical model of pulmonary fibrosis. The data were presented earlier today by William D. Hardie, M.D., Associate Professor, Pulmonary Medicine, Children's Hospital Medical Center, Cincinnati, Ohio, at the American Thoracic Society International Conference in San Diego, California. PX-866 is a small molecule inhibitor of phosphotidylinositol-3 kinase ("PI-3 kinase"), a key point of control of cellular responses including signaling of cell survival and growth, migration and metabolism.

"PI-3 kinase is part of a signaling pathway that is believed to play an important role in a number of human diseases that cause fibrosis, or scarring, of the lungs," said Dr. Hardie. "Our model in mice mimics these diseases by activating this pathway in the lungs with a growth factor called transforming growth factor alpha. PX-866 prevented both the deterioration in lung function and the fibrosis normally seen in the model. These results suggest that inhibition of the PI-3 kinase pathway might be beneficial in such human lung diseases as idiopathic pulmonary fibrosis."

"Although our current development program for PX-866 is focused on cancer, we are very interested in the role the PI-3 kinase pathway is thought to play in non-malignant diseases, including autoimmune and cardiovascular diseases," said Robert L. Kirkman, M.D., President and CEO of Oncothyreon. "We are pleased that Dr. Hardie plans further studies of PX-866 in pulmonary disease."

Oncothyreon is currently conducting a Phase 1 trial of PX-866 in patients with advanced metastatic cancer. Preliminary data from this trial are expected to be presented at the American Society of Clinical Oncology meeting later this mon
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SOURCE Oncothyreon Inc.
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