Navigation Links
Oncothyreon's PX-478 is effective in preclinical model of human lung cancer
Date:2/25/2008

ovel small molecule compound that inhibits the activity of hypoxia inducible factor (HIF)-1 alpha, a transcription factor that controls the expression of a number of genes important for growth and survival of cancer cells. Genes regulated by HIF-1 alpha contribute to diverse functions including new blood vessel growth (angiogenesis), use of glucose for energy, and protection against apoptosis (programmed cell death).

Preclinical data have demonstrated that PX-478 can induce apoptosis in experimental tumor models, as well as the down-regulation of factors which control angiogenesis, such as vascular endothelial growth factor (VEGF). PX-478 is effective when delivered orally in animal models, and has shown marked tumor regressions and growth inhibition in model systems across a range of cancers, including lung, ovarian, renal, prostatic, colon, pancreatic, and breast cancer. The wide variety of models that show sensitivity to PX-478 represents a large potential market for this product candidate. The ability to combine PX-478 with radiation therapy may further expand the opportunities for this novel compound.

About Oncothyreon

Oncothyreon is a biotechnology company specializing in the development of innovative therapeutic products for the treatment of cancer. Oncothyreon's goal is to develop and commercialize novel synthetic vaccines and targeted small molecules that have the potential to improve the lives and outcomes of cancer patients. For more information, visit http://www.oncothyreon.com.

Forward-Looking Statements

In order to provide Oncothyreon's investors with an understanding of its current intentions and future prospects, this release contains statements that are forward looking, including statements related to the ongoing Phase 1 trial of PX-478; the therapeutic and commercial potential of PX-478; and future clinical development plans for PX-478. These forward-looking s
'/>"/>

SOURCE Oncothyreon Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Phase III Trial Finds Pharmaxis Bronchitol Effective
2. New nanoparticle vaccine is more effective but less expensive
3. American and European Parkinsons Sufferers Find Chinese Stem Cell Treatment Effective, Proving Western Debates Moot
4. ProMed Alliance International Inc. Corporate Name and Trading Symbol Expected to Change Effective Tomorrow
5. InVitrias Animal Free Lacromin(TM) Provides a Cost-Effective Improvement Over Transferrin
6. MedImmune to Present RSV Surveillance and Cost-Effectiveness Data at American Academy of Pediatrics National Conference & Exhibition
7. Free White Paper Available for Clinical Laboratory Managers: Effectively Isolating Anaerobic Bacteria
8. DNA sensors found to be an effective artificial nose
9. Insmed President Interviewed for Follow-On Biologics Podcast: Insmed Inc. President Steve Glover Discusses Safe and Effective Biologic Therapies and Reduced Costs with The American Magazine
10. VaxGen and Raven Announce Form S4 Registration Statement Declared Effective
11. Genmab Announces Encouraging Preclinical Data for ofatumumab
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... , July 28, 2014 /PRNewswire/ -   JOLT , ... of companies to join its growing portfolio of startups. ... Toronto,s JOLT accelerator, and Cohort ... the roster. Since its launch in ... successfully raised  $7.5M of financing. Now at 23 investments, ...
(Date:7/28/2014)... Boston, MA (PRWEB) July 28, 2014 ... with two researchers to further develop potential treatments for ... brain tumor, in combination with their patented vaccine platform, ... and Duke University, are based on the work of ... of Neurosurgery at The Preston Robert Tisch Brain Tumor ...
(Date:7/28/2014)... DC (PRWEB) July 28, 2014 It’s a ... GI Bill benefits to further their post-secondary education are failing ... a study released this year. And according to an analysis ... this shortfall is veteran students’ uninformed choice of college majors, ... The details of the study: Some 51.7 percent of post-9/11 ...
(Date:7/28/2014)... and COLLEGE STATION, Texas , July 28, 2014 ... theatlashotel.com will be a 177-key, 4-star boutique hotel in the ... Bryan , Texas.  Photo - http://photos.prnewswire.com/prnh/20140725/130455 ... As the first hotel within ATLAS , ... a mixture of standard rooms and suites, a sleek restaurant and ...
Breaking Biology Technology:JOLT Announces the Next 6 Startups to Join its Summer 2014 Cohort 2JOLT Announces the Next 6 Startups to Join its Summer 2014 Cohort 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 2String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 4Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 2Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 3Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 4Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 2Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 3Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 4
... Comprehensive tutorials on the Comprehensive Microbial Resource enable researchers to quickly ... ... WA (PRWEB) December 10, 2008 -- OpenHelix today announced ... Resource (CMR). CMR is a public resource for the ...
... Neb., Dec. 9 Transgenomic, Inc.,(OTC Bulletin Board: ... an accreditation by the Commission on Laboratory Accreditation ... the results of a recent,on-site inspection. Transgenomic is ... nationwide. , Craig Tuttle, CEO of ...
... Inc.,(Nasdaq: NVAX ) and the ... a preclinical study of a Respiratory Syncytial Virus ... rights from the, University of Massachusetts Medical School ... of Paramyxovirus vaccines incorporating,certain Virus-Like-Particles ("VLPs"). This ...
Cached Biology Technology:New Online Tutorial for the Comprehensive Microbial Resource (CMR) 2Transgenomic Receives Accreditation From College of American Pathologists 2Transgenomic Receives Accreditation From College of American Pathologists 3NOVAVAX and the University of Massachusetts Medical School Announce Preclinical Study Results for a Respiratory Syncytial Virus ('RSV') Vaccine Candidate 2NOVAVAX and the University of Massachusetts Medical School Announce Preclinical Study Results for a Respiratory Syncytial Virus ('RSV') Vaccine Candidate 3NOVAVAX and the University of Massachusetts Medical School Announce Preclinical Study Results for a Respiratory Syncytial Virus ('RSV') Vaccine Candidate 4
(Date:7/28/2014)... 28, 2014)The Brain & Behavior Research Foundation today ... Freedman Prizes, recognizing exceptional clinical and basic research ... NARSAD Young Investigator Grants. The grants enable early ... and psychosocial research for the prevention, early detection, ... one in four people. , Six young scientistswinners ...
(Date:7/28/2014)... problems, many of these due to genetic factors. This ... genes, which reduce an individual,s ability to reproduce, to ... of Science that recently appeared in Nature Communications ... can it explain the high rates of male fertility ... causes of genetic diseases and their treatment. , ...
(Date:7/27/2014)... vitro study has revealed that nicotine and cotinine, a ... by a certain carcinogen in smoke. , The carcinogen ... tobacco leaves and ultimately ends up in the tobacco ... and liver, where it is activated by a variety ... mice has revealed that nicotine can partially interfere with ...
Breaking Biology News(10 mins):The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 2The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 3The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 4Mutations from Venus, mutations from Mars 2Nicotine found to inhibit DNA-strand break caused by a certain carcinogen in smoke 2
... North Pacific Ocean has increased since international and federal ... to a new study funded primarily by NOAA and ... Pacific region. However, some isolated populations of ... not recovered at the same rate and still suffer ...
... scarcity of energy commodities worldwide has heightened concerns about ... the Middle East, terrorism and resource nationalism. However, a ... for Public Policy suggests that, taken individually, many of ... less catastrophic than they seem at first glance. The ...
... Dr. Jon Miller of Stevens Institute of Technology and ... Program will present the 6th annual State of the ... as we head into the peak Jersey Shore tourism ... of Agriculture Charles Kuperus, Dr. Michael P. Weinstein, President ...
Cached Biology News:New study finds most North Pacific humpback whale populations rebounding 2Baker Institute study, conference weigh risks for global energy markets 2
... 5 ml Dynabeads Epoxy (4.5 m). ... reactive groups. Ideal for coupling of antibodies ... on initial coupling with covalent binding of ... sulphydryll groups (SH)) occurring within 16-20 hours. ...
... Normal;heading 1;heading ... types and experimental ... for standard transfection ... transduction systems. ViraPower ...
...
Mouse Anti-Gemin2...
Biology Products: