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Oncothyreon highlights corporate and clinical objectives for 2008
Date:1/28/2008

has shown marked tumor regressions and growth inhibition in such model systems across a range of cancers, including lung, ovarian, renal, prostate, colon, pancreatic, and breast cancer.

PX-866

The Company currently expects to file an Investigational New Drug (IND) application for PX-866 late in the first quarter of 2008. A Phase 1 trial of PX-866 in patients with advanced metastatic cancer is targeted to begin in the second quarter of 2008.

PX-866 is an inhibitor of the phosphatidylinositol-3-kinase (PI-3-kinase)/PTEN/Akt pathway, an important survival signaling pathway that is activated in many types of human cancer. The PI-3-kinase inhibitor PX-866 induces prolonged inhibition of tumor PI-3-kinase signaling following both oral and intravenous administration and has been shown to have potent in vivo anti-tumor activity in human ovarian and lung cancer, as well as intracranial glioblastoma, tumor models.

PX-12 Small Molecule

Enrollment is ongoing in the Phase 2 trial of PX-12 in patients with advanced pancreatic cancer whose tumors have progressed while being treated with gemcitabine or gemcitabine-containing regimens. Partial data from this trial is expected in the second half of 2008. An additional trial of PX-12 exploring a more-prolonged infusion regimen is currently expected to begin in the second quarter of 2008.

PX-12 is an irreversible inhibitor of thioredoxin (Trx-1), a protein that regulates many other proteins including hypoxia inducible factor (HIF)-1 alpha, vascular endothelial growth factor (VEGF) and activator protein 1 (AP-1). These factors play a critical role in cancer cell growth, survival and resistance to chemotherapy.

Pre-clinical Programs

In addition to its clinical stage product candidates, Oncothyreon has several pre-clinical programs in development. During 2008 the Company expects to select one program for clinical development in 2009. Potential candidates include BGLP-40, a completely
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SOURCE Oncothyreon Inc.
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