Navigation Links
Oncothyreon files investigational new drug application for PX-866 oncology compound
Date:5/1/2008

BELLEVUE, WA, May 1 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY) (TSX:ONY) today announced that it has filed an investigational new drug (IND) application with the U.S. Food and Drug Administration for PX-866, a small molecule phosphatidylinositol-3-kinase (PI-3-kinase) inhibitor for the treatment of advanced cancers. Following FDA review, Oncothyreon plans to initiate a Phase 1 clinical trial of PX-866.

"PX-866 is a potent inhibitor of phosphatidylinositol-3-kinase that has demonstrated preclinical anti-tumor activity in models of human ovarian cancer, lung cancer and intracranial glioblastoma," said Lynn Kirkpatrick, Ph.D., Chief Scientific Officer of Oncothyreon. "We believe that PX-866, an irreversible inhibitor of the kinase, will have dose and schedule advantages that may position it well in the current field of PI-3-kinase inhibitors."

"This IND for PX-866 demonstrates the continued advancement of Oncothyreon's small molecule oncology pipeline," said Robert L. Kirkman, M.D., President and CEO of Oncothyreon. In addition to the planned trial of PX-866, Oncothyreon is currently conducting a Phase 2 trial of PX-12, a small molecule inhibitor of thioredoxin-1, in patients with advanced pancreatic cancer and a Phase 1 trial of PX-478, a small molecule inhibitor of HIF-1 alpha, in patients with advanced solid tumors or lymphomas.

About PX-866

PX-866 is an inhibitor of the PI-3-kinase/PTEN/AKT pathway, an important survival signaling pathway that is activated in many types of human cancer. Aberrant activation and regulation of PI-3 kinase is implicated in a large proportion of human cancers including breast, glioma, colon, ovarian, prostate and melanoma, where it leads to increased proliferation and inhibition of apoptosis (programmed cell death). PX-866 has been shown to induce prolonged inhibition of tumor PI-3 kinase signaling following both oral and intravenous administration. The compound has been shown to have goo
'/>"/>

SOURCE Oncothyreon Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. Data for Oncothyreons PX-12 and PX-866 presented at AACR Annual Meeting
2. Oncothyreon announces data from multiple small molecule programs to be presented at American Association of Cancer Research Annual Meeting
3. Oncothyreon announces effectiveness of shelf registration statement
4. Oncothyreon announces issuance of patent for PX-867
5. Oncothyreon to present at upcoming investment conferences
6. Oncothyreon reports full year and fourth quarter 2007 financial results
7. Oncothyreon announces March 10th webcast of fourth quarter and full year financial results conference call
8. Oncothyreons PX-478 is effective in preclinical model of human lung cancer
9. Oncothyreon launches new corporate website
10. Oncothyreon to present at BIO CEO & Investor Conference
11. Oncothyreon highlights corporate and clinical objectives for 2008
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... , May 23, 2013 BioTrends Research ... advisory firms for specialized biopharmaceutical issues, finds that, ... infectious disease specialists reported that in the past ... intentionally delaying treatment) in anticipation of the next ... months ago, when only 6 percent reported that ...
(Date:5/23/2013)... (PRWEB) May 23, 2013 The New ... STEM industries, Black Data Processing Associates (BDPA), is hosting ... June 8, 2013. This all-day event will encourage students ... learn the ins and outs from many of the ... p.m. at the New Jersey Institute of Technology, the ...
(Date:5/23/2013)... , May 23, 2013 Pusan ... Inc., a private biotherapeutics and contract research company ... products for cancer, announced today a publication reporting ... treated with the oncolytic and immunotherapeutic vaccinia JX-594 ... research was published in the May 15 th ...
(Date:5/23/2013)... Bed bugs compromised Penn State. A report ... Meanwhile, My Cleaning Products offered complimentary samples of its bed ... without using harmful chemical elements. , Based on the ... building was actually a dormitory , My Cleaning Products ... May 13 and bed bug presence was confirmed on May ...
Breaking Biology Technology:The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 2The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 3Black Data Processing Associates (BDPA) New Jersey Hosts 10th Annual Families in Technology Day June 8, 2013 2Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 2Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 3Penn State Dorm Infested with Bed Bugs, My Cleaning Products Offers Complimentary Sample of Bed Bug Spray to Help Bed Bug Victims 2
... hold the key to production of tiny medical ... viruses or cancer markers, according to an interdisciplinary ... can be made more useful by assembling, at ... nanowires pretreated off chip," says Rustom B. Bhiladvala, ...
... 7 Eli Lilly and Company,(NYSE: LLY ) ... program, which was being conducted in partnership with Alkermes,Inc. ... as a potential,treatment for type 1 and type 2 ... result of any observations during AIR Insulin trials,relating to ...
... 7 Kendle (Nasdaq: KNDL ), a,leading, ... Chief Executive Officer Candace Kendle, PharmD, and,President and ... plans to sell shares of the company,s common ... are part of their personal,ongoing long-term strategy for ...
Cached Biology Technology:Assembly technique for tiny wires may eventually help detect cancer and other diseases 2Assembly technique for tiny wires may eventually help detect cancer and other diseases 3Lilly Announces Termination of AIR Insulin Program 2Lilly Announces Termination of AIR Insulin Program 3Lilly Announces Termination of AIR Insulin Program 4Kendle Leaders Adopt 10b5-1 Trading Plans 2
(Date:5/21/2013)... a "patient monitoring" device attached to a whale entangled ... how fishing lines changed a whale,s diving and swimming ... ability to eat and migrate, depletes their energy as ... result in a slow death. , The scientists in ... Dtag to a two-year-old female North Atlantic right whale ...
(Date:5/21/2013)... stem cells in the blood often jump into ... cells that can fight off illness. But repeated ... potentially leading to the development of serious blood ... researchers led by biologists at the California Institute ... models, the molecule microRNA-146a (miR-146a) acts as a ...
(Date:5/21/2013)... Cancers of all types become most deadly when they ... has reached this stage, it becomes very difficult for ... can develop. Now, researchers at the University of Missouri ... target lymphoma tumor cells wherever they may be in ... in the MU College of Veterinary Medicine, says being ...
Breaking Biology News(10 mins):Study reveals how fishing gear can cause slow death of whales 2Study reveals how fishing gear can cause slow death of whales 3Keeping stem cells strong 2MU researchers develop radioactive nanoparticles that target cancer cells 2
... Elsevier, a world-leading provider of scientific, technical and medical ... Dietetics announce that the Journal of the American Dietetic ... of Nutrition and Dietetics , mirroring the name change of ... "The new name, the Academy of Nutrition and Dietetics, ...
... of increasing concern about low vitamin D levels in the ... vitamin, scientists are reporting development of a much-needed reference material ... The report appears in ACS, journal Analytical Chemistry . ... vitamin D deficiency or insufficiency may be even more common ...
... The research assesses the benefits of white roofs and aims ... white roofs are suitable for their buildings and guide them ... Robert Doyle said Council had already put the research into ... "There has been a lot of talk about ...
Cached Biology News:Journal of American Dietetic Association becomes Journal of the Academy of Nutrition and Dietetics 2New standard for vitamin D testing to ensure accurate test results 2White roofs to make for cooler Melbourne buildings 2
... Pyrophosphate Detection Kit,provides a fast, convenient ... inorganic pyrophosphate (PPi ) produced,by a ... DNA and,RNA polymerizations, cyclic AMP formation ... enzymatic activation of fatty acids to,form ...
... contains a unique β-agarose digesting enzyme developed ... intact DNA and RNA from low melting ... TAE, TBE, MOPS, or phosphate buffers. The ... TAE, TBE, MOPS, and phosphate electrophoresis buffers ...
Request Info...
... The new Thermo Electron RapidStak provides valuable ... Utilizing a unique buffer nest technology for ... the RapidStak provides fast, reliable automation for ... and walk-away confidence. The RapidStak can be ...
Biology Products: