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Oncothyreon announces clinical data from three product candidates presented at American Society of Clinical Oncology (ASCO) Annual Meeting
Date:5/30/2009

>Final results from two Phase 1b trials of PX-12, an inhibitor of thioredoxin, were presented by Dr. R.K. Ramanathan, Scottsdale Clinical Research Center, Scottsdale, Arizona. These trials in 32 patients were designed to assess the tolerability and pharmacodynamic activity of both 24-hour and 72-hour infusions of PX-12. In both trials, doses up to 400 mg/m(2)/day were well-tolerated. PX-12 was shown to lower levels of circulating thioredoxin in patients whose starting levels were at least three-fold greater than normal. Three patients achieved stable disease.

About Stimuvax

Stimuvax is an investigational therapeutic cancer vaccine designed to induce an immune response to cancer cells that express MUC1, a glycoprotein antigen widely expressed on common cancers. MUC1 is over-expressed on many cancers such as lung cancer, breast cancer, prostate cancer and colorectal cancer. Stimuvax is thought to work by stimulating the body's immune system to identify and destroy cancer cells expressing MUC1. Merck KGaA currently is conducting a global Phase 3 trial of Stimuvax known as START (Stimulating Targeted Antigenic Responses To NSCLC). START is a randomized, double-blind, placebo-controlled study that will evaluate patients with documented unresectable stage III NSCLC who have had a response or stable disease after at least two cycles of platinum-based chemo-radiotherapy. The Phase 3 trial is expected to enroll more than 1,300 patients in over 30 countries. For more information on the START trial, or to find a participating center and eligibility criteria, log on to www.nsclcstudy.com or www.clinicaltrials.gov.

About PX-866

PX-866 is an inhibitor of the PI-3-kinase/PTEN/AKT pathway, an important survival signaling pathway that is activated in many types of human cancer. Aberrant activation and regu
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