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Oncolytics Biotech Inc. Collaborators to Present Reovirus Research at ASGT Meeting
Date:5/30/2008

CALGARY, May 30 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. (TSX: ONC, NASDAQ: ONCY) announced today that two presentations covering preclinical work using the reovirus are scheduled to be delivered by Dr. Richard Vile of the Mayo College of Medicine, Rochester, Minnesota, at the American Society of Gene Therapy (ASGT) annual meeting in Boston, MA. The meeting runs from May 28 to June 1, 2008.

A poster presentation entitled "Combination Immunotherapy and Oncolytic Virotherapy for the Treatment of Malignant Mesothelioma" is scheduled to be presented on Friday, May 30, 2008. The poster covers preclinical work using oncolytic viruses including reovirus against mesothelioma, a rare but deadly cancer. In vitro data show that mesothelioma cells are sensitive to and support replication of reoviruses. In addition, data suggesting how anti-tumour immunity can be enhanced will be presented.

An oral presentation entitled "Purging Lymph Node Metastases with Adoptive T Cell Therapy, Oncolytic Virotherapy and Immunotherapy" is scheduled to be presented on Saturday, May 31, 2008. In many cancers, disease spreads to other parts of the body via the lymph nodes. In this study, the investigators demonstrated that normal T-cells pre-loaded with reovirus localize to lymph nodes, spleen and liver and deliver the virus to sites of metastatic disease. In addition, killing the tumour cells in the lymph nodes and spleen by reovirus generated potent anti-tumour immunity, preventing repopulation of the lymph nodes and spleen by further waves of cells spreading from the primary tumour. The researchers are continuing to investigate methods of improving virus delivery, and developing clinical protocols that will examine purging lymph nodes of tumor cells using reovirus.

About Oncolytics Biotech Inc.

Oncolytics is a Calgary-based biotechnology company focused on the development of oncolytic viruses as potential cancer therapeutics. Oncolytics' clinical progr
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