Navigation Links
OncoGenex Provides Update on Two-Year Survival Data from Ongoing Phase 1/2 Clinical Trial of OGX-011 in Non-Small Cell Lung Cancer
Date:2/4/2009

ith a standard first-line NSCLC chemotherapy regimen that included a platinum-based regimen plus gemcitabine. 51% of patients had adenocarcinoma, 16% had squamous cell carcinoma and 33% of patients had undifferentiated or unspecified non-small cell lung cancer. The primary objectives of the study were designed to estimate objective response rates of OGX-011 in combination with a gemcitabine/platinum-based regimen, establish the recommended dose of OGX-011, and determine the safety and tolerability. Secondary objectives were aimed to estimate the progression-free survival, overall survival, the pharmacokinetic profile of OGX-011, and the effect of OGX-011 on serum clusterin levels.

    -------------------------------------------------------------------------
    Median Follow-up                                  33 months
    Number of Patients Alive (follow up ongoing)      16/81 (20%)
    Median Overall Survival                           14.1 months (0.13-45.9)
    Number of Pts Surviving
              Greater than or equal to 12 months      54% (43%-64%: 95% CI)
              Greater than or equal to 18 months(1)   39% (28%-49%: 95% CI)
              Greater than or equal to 2 years(1)     30% (21%-40%: 95% CI)
    -------------------------------------------------------------------------
    (1) Kaplan-Meier Estimates

69% of patients experienced disease control (complete response =1%, partial response =30%, stable disease =38%), 26% experienced disease progression, and response was not assessable in 5%. Median progression-free survival was 4.6 months (0.06 - 17.7 months). Investigators concluded that the treatment with OGX-011 was generally well tolerated, and toxicities were consistent with the adverse event profile for gemcitabine in combination with a platinum-based regimen in this population.

Serum clusterin analysis for this NSCLC study showed that OGX-011 treatment significantly decreased the mean ave
'/>"/>

SOURCE OncoGenex Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. OncoGenex reports lead drug candidate OGX-011 achieved primary endpoint in Phase 2 Trial with second-line chemotherapy for prostate cancer
2. Sonus Pharmaceuticals and OncoGenex Technologies to Merge
3. OncoGenex to present at the Needham & Company 7th Annual Biotechnology & Medical Technology Conference
4. OncoGenex increases economic interest in lead cancer drug OGX-011
5. OncoGenex receives completed Special Protocol Assessment for primary registration study of lead drug candidate OGX-011
6. Sonus Pharmaceuticals and OncoGenex Technologies complete business combination; OncoGenex Pharmaceuticals to commence trading on NASDAQ Capital Market today
7. FDA Grants Fast Track Designation for OncoGenex Pharmaceuticals Lead Product Candidate OGX-011
8. OncoGenex Pharmaceuticals announces out-license of TOCOSOL Paclitaxel to Eagle Pharmaceuticals
9. OncoGenex To Present At The BioContact Quebec 2008 Annual Conference
10. OncoGenex Achieves Key Regulatory Milestone for Lead Product Candidate, OGX-011
11. OncoGenex Pharmaceuticals to Release Third Quarter Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... Gatos, CA (PRWEB) May 29, 2015 ... company addressing multi-drug-resistant organisms (MDROs), announced that initial ... for same-shift bacterial detection and susceptibility testing from ... asm2015 on May 31, 2015 in New ... new class of molecular diagnostics that can quickly ...
(Date:5/29/2015)... , May 29, 2015 Delcath Systems, ... and medical device company focused on oncology with ... metastatic liver cancers, announces that results of a ... uveal melanoma patients with hepatic metastases with the ... highlighted in an on-line abstract at the American ...
(Date:5/29/2015)... Research and Markets ( http://www.researchandmarkets.com/research/7bf7ff/cytogenetics ) ... report "Cytogenetics - Technologies, Markets and Companies" ... deals with cytogenetics in a broader sense rather ... chromosome structure and identify abnormalities related to disease. ... also referred to as molecular cytogenetics. The scope ...
(Date:5/29/2015)... (PRWEB) May 29, 2015 Translation is frequently ... is for a good reason--if used in a way that ... the offering of a business product or service offering. ... can have a positive effect on a company's bottom line: ... that anyone in the world can use, why not offer ...
Breaking Biology Technology:Data Highlighting GeneWEAVE’s Smarticles™ Technology to be Presented at the 115th General Meeting of the American Society for Microbiology (asm2015) 2Data Highlighting GeneWEAVE’s Smarticles™ Technology to be Presented at the 115th General Meeting of the American Society for Microbiology (asm2015) 3Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 2Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 3Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 4Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 5Global Cytogenetics Market Report 2015-2024 - Technologies, Markets and Companies 2Global Cytogenetics Market Report 2015-2024 - Technologies, Markets and Companies 3Three Ways Translation Can Help Businesses Grow 2
... and OTTAWA, Nov. 20 Sports and,nutritional product ... http://www.naturalnutritioninc.com announced today that it has,launched an ... Lightning Pain Relief Cream. Made from a combination ... be marketed,on the internet and television. Natural ...
... Spheris to be the First Provider of Clinical Documentation Technology, ... ... Tenn., Nov. 20 Spheris has been selected as,the first ... of the nation,s leading group purchasing organizations.,Under the parties, agreement, ...
... CRY ),a biomaterials, medical device and tissue processing company, ... 19th Annual Piper Jaffray,Health Care Conference at the Pierre ... Steven G. Anderson, president and CEO of CryoLife, ... p.m. EST. CryoLife,s live presentation may be accessed ...
Cached Biology Technology:Natural Nutrition Launches International Marketing Campaign for New All Natural Analgesic: BLUE LIGHTNING(TM) Fast Pain Relief 2Provista Awards Agreement to Spheris 2CryoLife to Present at 19th Annual Piper Jaffray Health Care Conference in New York 2
(Date:5/7/2015)... 7, 2015 Fingerprint Cards ... and FPC1035, FPC,s smallest touch fingerprint sensors to ... considered for integration on the backside of the ... increased possibilities to integrate touch fingerprint sensors in ... improves possibilities for module manufacturers to customize the ...
(Date:4/27/2015)... -- For more than four decades, AUVSI,s Unmanned Systems ... worldwide event for the unmanned land, sea, and air ... any local, national, or trade news organization interested in ... current applications of unmanned technologies. The conference will explore ... industry, and how it will soon impact the lives ...
(Date:4/21/2015)... , April 21, 2015 ... evolving government policies are boosting access control systems market ... According to a recently published report by TechSci ... 2020 ", the access control systems market in ... USD1.2 billion by 2020.The access control systems market in ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
... When a pathogen attacks a plant, infection usually follows ... of researchers at the University of California, Riverside focused on ... of the 19 th century by infecting potato plants, ... system. The genus Phytophthora contains many notorious ...
... As fibers go, there,s never been anything quite like spider silk. ... holds up. It is five times stronger than steel and can ... right back like new. Ounce-for-ounce spider silk is even stronger than ... be understandable to think that science knows all there is to ...
... needs to eat. But it,s a dog-eat-dog world, and with ... To cope with this vicious reality, a tiny insect that ... physical protection from its beetle predator. The pest ... numerous countries in recent years has caused immeasurable loss of ...
Cached Biology News:Scientists identify genetic mechanism that contributed to Irish Famine 2Scientists identify genetic mechanism that contributed to Irish Famine 3Stanford researcher sheds new light on the mysteries of spider silk 2Stanford researcher sheds new light on the mysteries of spider silk 3Stanford researcher sheds new light on the mysteries of spider silk 4Pest uses plant hairs for protection 2
Anti-Conjugated Quinaldic Acid...
... stain kits are optimized for use ... Dodeca stainers. This silver stain kit ... in polyacrylamide gels and are mass ... concentrate, silver reagent concentrate, background reducer ...
The AVR9-8 stream-select valve is a 9-port, 8-position valve for use with the BioLogic DuoFlow system. This valve is used for high-pressure stream selection....
... Miscellaneous: Versatile stain for staining RNA (bluish-purple), DNA (blue), ... TLC ≥ 90 % Cation traces: Ca ≤ ... mg/kg Cr ≤ 5 mg/kg Cu ≤ 5 mg/kg ... ≤ 5 mg/kg Mn ≤ 5 mg/kg Na ≤ ...
Biology Products: