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OncoGenex Pharmaceuticals Announces OGX-011 Treatment Provides Survival Benefit in Randomized Phase 2 Trial in Advanced Metastatic Prostate Cancer
Date:5/30/2009

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BOTHELL, WA, and VANCOUVER, May 30 /PRNewswire-FirstCall/ - OncoGenex Pharmaceuticals, Inc. (NASDAQ: OGXI) today announced the final results of a Randomized Phase 2 Trial presented during an oral presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting. Analyses indicated a survival benefit in patients treated with OGX-011 in combination with docetaxel compared to docetaxel alone - the current standard care for patients with advanced prostate cancer:

    1)  The median overall survival in patients with advanced metastatic
        prostate cancer who were treated with OGX-011 plus docetaxel in a
        randomized Phase 2 trial was 23.8 months compared to 16.9 months for
        patients treated with docetaxel alone -- a 6.9 month observed
        survival advantage for the OGX-011 arm.

    2)  The unadjusted hazard ratio (HR), a measure used to compare the death
        rates between treatment groups, was 0.61, representing a 39% lower
        rate of death for patients treated with OGX-011.

    3)  A prospectively defined multivariate analysis indicated that the
        significant predictors of overall survival were treatment arm,
        performance status, and presence of metastases other than in bone or
        lymph nodes. Patients treated with OGX-011 had a rate of death 51%
        lower than patients treated with docetaxel alone (HR=0.49;
        p=0.012). Additional exploratory analyses found that the
        lower rate of death was associated with the effect of OGX-011
        treatment even when varying amounts of chemotherapy were administered
        (i.e. OGX-011 treatment resulted in a lower rate of death when
        compared to the control arm for patients receiving 6 or less cycles
        of chemotherapy as well as for patie
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SOURCE OncoGenex Pharmaceuticals, Inc.
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1. OncoGenex Pharmaceuticals Announces OGX-427 Treatment Demonstrates Safety, Evidence of Declines in Circulating Tumor Cells and Reductions in Tumor Markers in a Phase 1 Cancer Trial
2. OncoGenex Pharmaceuticals to Webcast ASCO Reception on May 30, 2009
3. OncoGenex Pharmaceuticals Announces Release of Two ASCO Abstracts: Impact of OGX-011 on Survival in Randomized Phase 2 Trial and Phase 1 Safety Data for OGX-427
4. OncoGenex Pharmaceuticals Clinical Programs to be Featured in Oral Presentations at the American Society of Clinical Oncology Annual Meeting
5. OncoGenex Reports First Quarter Financial Results
6. OncoGenex Pharmaceuticals to Release First Quarter Financial Results
7. OncoGenex Receives Confirmation from FDA on the Design of a Second Phase 3 Trial Evaluating OGX-011 for the Treatment of Advanced Prostate Cancer
8. OncoGenex Pharmaceuticals Named Life Sciences Company of the Year by LifeSciences British Columbia
9. OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009
10. OncoGenex Pharmaceuticals to Webcast Financial Results for Fourth Quarter and Fiscal Year 2008 and Provide Outlook for 2009
11. OncoGenex Provides Update on Two-Year Survival Data from Ongoing Phase 1/2 Clinical Trial of OGX-011 in Non-Small Cell Lung Cancer
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