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OncoGenex Announces Publication of Custirsen Phase II Clinical and Pre-Clinical Data in Leading Cancer Journals
Date:9/6/2011

sease progression while on or shortly after first-line docetaxel treatment," said Dr. Fred Saad, Professor of Surgery/Urology at the University of Montreal and lead investigator on the study. "These data suggest that custirsen may restore docetaxel sensitivity and potentially provide improvements in pain control for this difficult-to-treat patient population."

The authors concluded that the study's results, which demonstrated feasibility, safety and pain relief, as well as an association of low serum clusterin levels with longer survival, provides a consistent signal that warrants further testing of custirsen combined with second-line chemotherapy in mCRPC.

The abstract can be found at the following link:

http://clincancerres.aacrjournals.org/content/17/17/5765.abstract

Pre-Clinical Data Published in Cancer Research

Pre-clinical data published in the September 1, 2011 issue of Cancer Research, demonstrated that clusterin inhibition using custirsen synergistically enhanced Heat-shock 90 (Hsp90) inhibitor activity by suppressing the heat shock response in CRPC.

Heat-shock 90 (Hsp 90) inhibitors trigger the elevation of compensatory survival mechanisms that result in the production of clusterin, leading to cancer cell survival and treatment resistance. Results of this study demonstrated that when custirsen was combined with the Hsp90 inhibitor PF-04929113 or 17-AAG, the compounds worked synergistically to inhibit CPRC tumor cell growth in mice.

"These data support the broad, potential applicability of custirsen in combination with various anti-cancer treatments," said Dr. Martin Gleave, Director of The Vancouver Prostate Centre at The University of British Columbia and researcher on the study. "This study is an example of how we continue to develop a greater understanding of cancer treatment resistance and iden
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SOURCE OncoGenex Pharmaceuticals, Inc.
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