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Omixon Launches Holotype HLA for NGS-based HLA Genotyping
Date:7/18/2014

Budapest, Hungary & Cambridge, MA (PRWEB) July 18, 2014

Global biotechnology company Omixon, headquartered in Budapest with US offices in Cambridge, MA, announces the launch of Omixon Holotype HLA™ - a combination Assay and Software product that leverages the power of Next Generation Sequencing (NGS), for use on the Illumina® MiSeq sequencing platform. The assay and software have been optimized through collaboration with The Children’s Hospital of Philadelphia (CHOP) and will include a new software product, Omixon HLA Twin™, that features two different algorithms for orthogonal validation by data analysis and the most accurate high-resolution genotyping available.

“This new approach sets the stage for the thorough and accurate characterization of the HLA genes,” says Professor Dimitri Monos, Director of the Immunogenetics Laboratory in the Department of Pathology and Laboratory Medicine at CHOP. “These genes are critical for any antigen-specific immune response and found to be very important for transplantation, have been associated with many autoimmune diseases, play a critical role in infectious diseases and most recently their relevance to pharmacogenomics has been demonstrated, as they influence immunological reactions to particular medications. It is very likely that this new technology will provide additional insights that may further elucidate the role of these genes/molecules in each of these disciplines and beyond in rather surprising and unpredictable ways.” The assay provides targeted amplification and library preparation reagents for the whole gene coverage of HLA-A, B, C and DQB1, and partial coverage for HLA-DRB1.

The resulting Illumina data provides even and deep coverage, allowing Omixon’s new HLA Twin software to fully resolve phase for bo
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