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Omeros Awarded Grant from The Michael J. Fox Foundation to Evaluate Novel Parkinson's Disease Target
Date:1/6/2009

SEATTLE, Jan. 6 /PRNewswire/ -- Omeros Corporation today announced that The Michael J. Fox Foundation has awarded it a $465,000 grant against milestones to support the Company's collaboration with The Parkinson's Institute to evaluate Omeros' recent discovery of a new target for the treatment of Parkinson's disease. Located in regions of the brain responsible for Parkinson's disease, Omeros is the first to link its novel target to the treatment of any movement disorder, including Parkinson's disease and Restless Legs Syndrome. Omeros will continue to retain all of its rights associated with this novel target.

"We are pleased that The Michael J. Fox Foundation is joining our efforts to develop a novel treatment for Parkinson's disease," stated Gregory A. Demopulos, M.D., Chairman and CEO of Omeros. "The Foundation is a well-recognized leader in Parkinson's research, and its support will be key to testing the potential of our proprietary approach for treating patients living with the disease."

Under Omeros' collaboration with The Parkinson's Institute, preclinical studies using a widely accepted and highly predictive model for the symptomatic treatment of Parkinson's disease are being conducted on one or more compounds that block Omeros' proprietary target. Omeros' earlier studies conducted at Emory University by Gary W. Miller, Ph.D. in a similar model showed that compounds blocking this novel target were as effective as levodopa, or L-DOPA, at doses 50- to 100-times lower than those of L-DOPA. L-DOPA has been the standard treatment for Parkinson's disease for nearly 40 years but is associated with profound side effects including dyskinesias, hallucinations, sleep disorders and cognitive impairment. Omeros plans to explore the clinical utility of one or more of the compounds currently under evaluation both singly and in conjunction with L-DOPA.

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