Navigation Links
Omeros Announces it has Unlocked 30 Percent of Class A Orphan GPCRs
Date:1/10/2012

SEATTLE, Jan. 10, 2012 /PRNewswire/ -- Omeros Corporation (NASDAQ: OMER) today reported that it has identified compounds that interact selectively with each of GPR25, GPR32, GPR80, GPR135 and MAS1, bringing the total number of orphan G protein-coupled receptors (GPCRs) unlocked by Omeros to 23, representing 30 percent of the Class A orphan GPCRs. To date, the number of orphans unlocked by Omeros for drug development equals half of the total number of GPCRs currently targeted by more than 30 percent of all marketed drugs. There are approximately 120 orphan GPCRs and Omeros expects to unlock a large percentage of them, focusing first on Class A orphan GPCRs.

GPR25 is linked to arterial stiffness, which is associated with atherosclerosis, myocardial infarction and stroke. GPR32 is tied to acute inflammation. GPR80 is linked to hepatocellular carcinoma and MAS1 to cognitive impairment, a central component of debilitating disorders such as Alzheimer's and other dementias. No potential indications have yet been linked to GPR135, although it is expressed throughout the body and widely, and preferentially, in the brain. Omeros is in the process of filing broad patent applications around its unlocked orphan GPCRs and compound optimization efforts are underway.

"Using our proprietary high-throughput assay, we are moving rapidly through the 77 Class A orphans and expect to complete screening of them all in 2012," said Gregory A. Demopulos, M.D., chairman and chief executive officer of Omeros. "We believe the compounds that we have uniquely identified for our unlocked orphan GPCRs enable the development of drug candidates selectively targeting each of those receptors, and we are working diligently to advance, protect and capitalize on our discoveries."   

Ongoing GPCR Program

Omeros has begun screening orphan GPCRs against its small-molecu
'/>"/>

SOURCE Omeros Corporation
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. Omeros Announces It Has Unlocked Over 20 Percent of Class A Orphan GPCRs
2. Omeros to Present at Rodman and Renshaw 13th Annual Healthcare Conference
3. Omeros to Present at Two Upcoming Conferences
4. Omeros to Present at Future Leaders in the Biotech Industry Conference
5. Omeros to Present at Needham Healthcare Conference
6. Omeros Corporation Awarded $1.7 Million in Grants Under the Qualifying Therapeutic Discovery Project Program
7. Omeros Announces Additional Support from the National Institute on Drug Abuse for Clinical Studies in Addiction Program
8. Omeros Secures $40 Million Committed Equity Financing Facility
9. Omeros To Webcast Presentation at Ninth Annual Needham Healthcare Conference
10. Omeros to Webcast Presentation at Deutsche Bank 35th Annual Health Care Conference
11. Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... Baylor Research Institute (BRI) at Dallas ... in Phoenix, AZ , today announce an ... for patients with a broad range of cancers. Aligning the ... trials and access to technology to drive the development of ... across Baylor Scott & White Health,s 49 hospitals ...
(Date:5/21/2015)... N.J. (PRWEB) May 21, 2015 ... circulation audit and been admitted to BPA Worldwide ... BPA Worldwide will track audience data for Specialty ... coverage. , “By becoming a member of ... dedication to providing our clients with the most ...
(Date:5/21/2015)... 21, 2015 uBiome, the leading ... partnership with PicnicHealth, a healthcare company that collects ... with Inflammatory Bowel Disease (IBD) will receive a ... uBiome research kit. Both companies were funded by ... , For more information on this partnership and ...
(Date:5/21/2015)... Worms, Germany (PRWEB) May 21, 2015 ... announces that its manufacturing facility in Worms, Germany ... EXCiPACT™, an independent subsidiary of the International Pharmaceutical ... three Grace facilities that produce its SYLOID® FP ... now received GMP certification, following the Curtis Bay, ...
Breaking Biology Technology:Precision Medicine Collaboration to Increase Options for Cancer Patients 2Precision Medicine Collaboration to Increase Options for Cancer Patients 3Precision Medicine Collaboration to Increase Options for Cancer Patients 4Specialty Pharmacy Times Joins BPA Worldwide 2uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 3Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2
... Nov. 25 /PRNewswire/ - The Atlantica BioEnergy Task Force ... with political, business and education leaders from across Atlantic ... the forestry sector. , "The global forest ... all stakeholders to look for environmentally sustainable ways to ...
... 25 BioMarin Pharmaceutical,Inc. (Nasdaq: BMRN ) today ... a company update at the Piper,Jaffray Healthcare Conference in New ... , Interested parties may ... investor section of the BioMarin website, http://www.BMRN.com . A,replay ...
... Meet Dr. David Onslow, owner of,Excellon, a biotech company ... his team of scientists rise to the top with the ... about a,mysterious night in the 1970s when he witnessed a ... his wife Kate, and a team of doctors at,the foot ...
Cached Biology Technology:Atlantica Bioenergy Task Force hosts industry and government leaders 2Atlantica Bioenergy Task Force hosts industry and government leaders 3BioMarin to Present at the Piper Jaffray Healthcare Conference 2'Far From Beyond': A Glimpse into the World of Biotechnology and the Future of the Free World 2
(Date:5/14/2015)... 2015  Verificient Technologies, Inc., a technology ... remote proctoring, announced a new alliance partnership ... creator of the Canvas Learning Management System ... will benefit from the seamless integration of ... a fully integrated multifactor biometrics behavioral application, ...
(Date:5/11/2015)... 2015  Through a well-rounded UAS delegation representing private industry, ... strong showing at AUVSI,s Unmanned 2015 conference last week in ... Ohio,s UAS industry met with over 200 hundred ... along the UAS ecosystem. "Our message is ... for Aerospace Rich Knoll . "If you want to ...
(Date:5/10/2015)... GOTHENBURG, Sweden , May 11, 2015 ... touch fingerprint sensors FPC1025 and FPC1155 from the distributor World ... one of FPC,s distributors in Asia . ... the sensors will be used by smartphone manufacturers in ... is included in the communicated revenue guidance of + 1 000 ...
Breaking Biology News(10 mins):Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2
... unknown mechanism in the body which regulates a hormone ... of blood pressure, pain and appetite. The breakthrough could ... problems connected with these functions in the future. ... London found that lactate essentially lactic acid ...
... scientists at King,s College London have identified a gene linking ... intelligence. The study is published today in Molecular Psychiatry ... forms of intellectual impairment. The researchers looked at ... It is known as ,grey matter, and plays a key ...
... used to treat breast cancer, also kills a fungus that ... findings, which could lead to new treatments for a disease ... mBio , the online open-access journal of the American Society ... additional animal studies to see if tamoxifen can be used ...
Cached Biology News:New research sheds light on how the body regulates fundamental neuro-hormone 2Scientists identify gene linking brain structure to intelligence 2Breast cancer drug fights fungal disease 2
X-Gal, 1 g. 5-Bromo-4-chloro-3-indolyl-b-d-galactoside.Histochemical substrate for b-galactosidase, used in blue/white screening.Store at -20 C. Protect from moisture. Category: Nucleotides & Enzymes...
Recombinant Rat Fas Ligand/TNFSF6...
Request Info...
FGF Receptor 1 Antibody...
Biology Products: