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Octapharma Grants Program Awards First Research Grant to Rush University Medical Center
Date:8/2/2010

n suggested by some; in particular, discontinuing prophylaxis after a boy reaches skeletal maturity. The rationale offered is that the impact of hemarthrosis on mature joints is less deleterious than on those of younger patients.

"We expect that the data will not support the hypothesis that bleeding into the mature joint is less detrimental compared to hemarthrosis in the younger skeletally immature joint," said Dr. Valentino. "This data will indicate that prophylaxis should be continued in adults."

To test the hypothesis that older, skeletally mature joints are less susceptible to blood-induced joint damage, mice deficient in factor 8 gene expression will be studied. Animals at different ages will be subjected to a single massive experimental hemarthrosis and then sacrificed in the month after the joint bleeding to assess the severity of hemophilic arthropathy. The diameter of the affected knee joints of immature and mature mice will be compared. The joints will then be isolated and subjected to histological and image analysis using micro-computed tomography.

The Octapharma Grants Committee is currently reviewing the first cycle of 2010 grant applications and recipients will be announced following the analysis. The deadline for the next cycle of 2010 submissions will be September 31. Please visit www.octapharmagrants.com for a complete description of the grants program.

About the Octapharma Group

Headquartered in Lachen, Switzerland, Octapharma is one of the largest human protein products
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