Navigation Links
Ocera Therapeutics Completes First in Human Studies with OCR-002 for the Treatment of Hyperammonemia and Hepatic Encephalopathy
Date:12/15/2010

ortance being placed on accelerating the development of drugs like this in order to reach the patients in need as quickly as possible."  Ocera plans to initiate Phase 2 studies in 2011.

OCR-002 data presented at EASL, AASLD, and ISHEN in 2010 have confirmed that OCR-002 can consistently lower ammonia in multiple preclinical models of cirrhosis and acute liver failure and has been correlated with normalization of intracranial pressure, brain edema and neurologic function.

"OCR-002 is a promising new therapy for the acute care of patients with hyperammonemia and hepatic encephalopathy, a patient population for whom treatment options are currently very limited," stated Dr. Tarek Hassanein, Professor of Medicine and Director of Southern California Liver Centers, Coronado, CA.

About OCR-002

OCR-002 (ornithine phenylacetate) is a novel injectable treatment with a unique mechanism of action that directly reduces toxic levels of ammonia in the blood. When the liver is unable to detoxify ammonia, patients are at risk of developing hepatic encephalopathy, a condition that can lead to coma and death, requiring hospitalization that cost the U.S. healthcare system $1.2 billion every year. The compound has demonstrated in several published studies that it has a rapid and sustained effect in lowering toxic ammonia levels and can prevent severe neurologic complications in animal models of acute liver failure and liver cirrhosis.  Ocera Therapeutics licensed OCR-002 from University College of London in December 2008.

About Hepatic Encephalopathy

Hepatic Encephalopathy (HE) is caused by the accumulation of toxic substances in the bloodstream, including ammonia, that are normally removed by the liver.  HE ranges in severity from disorientation to confusion, coma and even death.  With severe liver impairment, toxic substances such as ammonia accumulate in the blood and impair the function of brain cells.  
'/>"/>

SOURCE Ocera Therapeutics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Ocera Therapeutics Completes Phase 2B Enrollment in the ASTUTE Trial
2. Ocera Therapeutics Presents Data on AST-120 in Patients With Hepatic Encephalopathy at the European Association for the Study of Liver Disease Annual Meeting
3. Dr Stephan Rietiker Joins BioCeramic Therapeutics
4. Sir Richard Sykes Joins BioCeramic Therapeutics as Chairman
5. Talecris Biotherapeutics Announces Jury Verdict in Contract Dispute
6. ViroPharma Incorporated and Idis Partner to Facilitate International Access to Certain ViroPharma Therapeutics Through Named Patient Program
7. Reportlinker Adds Global Bladder Cancer Therapeutics Industry
8. Intarcia Therapeutics Executive Chairman, Kurt Graves to Present at Lazard Capital Markets 7th Annual Healthcare Conference
9. Argos Therapeutics to Present Corporate Overview and Next Steps in Clinical Development of Arcelis™ Immunotherapy at Lazard Capital Markets 7th Annual Healthcare Conference
10. Silence Therapeutics Lead RNA Interference Therapeutic Prevents Spread of Cancer to Lungs
11. Halozyme Therapeutics Reports Third Quarter 2010 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... (PRWEB) August 20, 2014 High ... and apply the most complete climate and Earth ... demanding climate change issues. , Eight national laboratories, ... with the National Center for Atmospheric Research, four ... new effort. Other participating national laboratories include Argonne, ...
(Date:8/20/2014)... Not long ago, it was more or less ... in the development cycle – even after the final ... that, like many things GxP, expectations for early E&L ... drug sponsors have been required by authorities to provide ... I/II. It’s not only clinical trial material containers causing ...
(Date:8/20/2014)... August 20, 2014 GraphDB™ ... today including improvements to the enterprise replication cluster, ... for Lucene, SOLR and Elasticsearch. This release happens ... high performance triplestore – GraphDB™ was formerly known ... deploying the only mature enterprise resilient RDF triplestore ...
(Date:8/19/2014)... A Geisinger researcher on a personal crusade ... for Disease Control and Prevention (CDC) award recognizing his ... Joseph Boscarino , Ph.D. MPH, senior ... of researchers nominated for the Centers for Disease Control ... Data Methods and Study Design. "Hepatitis C ...
Breaking Biology Technology:New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3
... Madison, Wis. - Leslie Hearn's first rule for the ... ,While some techno jargon is unavoidable, the value of plain-spoken ... TDS Telecom . , , Leslie Hearn ... project," she said. "There has to be a lot of ...
... music consumers, the rights of artists are as often ... The studios appeal to consumers, saying that downloading without ... stifle creativity. , ,In the great food chain of ... creatures, paid pennies to the studios' dollars. , ,For ...
... Wis. - William R. Hendee will retire effective June ... at the Medical College of Wisconsin , and devote ... who also will retire as president of the MCW Research ... College conducts a national search for a permanent successor it ...
Cached Biology Technology:CIO Leadership Series: Leslie Hearn, TDS Telecom 2CIO Leadership Series: Leslie Hearn, TDS Telecom 3CIO Leadership Series: Leslie Hearn, TDS Telecom 4Going ga-ga over lala.com 2Medical College grad school dean Bill Hendee to retire 2
(Date:8/20/2014)... approximately 3 million infants, a team of scientists across ... Massachusetts Medical School, have shown that newborn screening for ... public health newborn screening programs. Data from 11 newborn ... the Journal of the American Medical Association ... newborns is higher than previously thought and believed to ...
(Date:8/20/2014)... suffered concussions ready to return to action? A new ... athletes who head back on the field with medical ... their abilities to simultaneously walk and do simple mental ... their balance and/or altered walking speed, was found in ... returned to activity in less than a month. Seven ...
(Date:8/20/2014)... bags could one day be made out of cocoa, ... now reporting. The novel process they developed and their ... agricultural and plastic waste problems, appear in the ACS ... Bayer and colleagues at the Italian Institute of Technology ... 2012, its production reached 288 million tons worldwide, but ...
Breaking Biology News(10 mins):Newborn screening expansion offers early diagnosis and treatment to infants with SCID 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 3Recovery reversal seen in Oregon study of returning concussed athletes 2Recovery reversal seen in Oregon study of returning concussed athletes 3
... Disorder , (#1119044, Wednesday, October 26, 3:00 PM Eastern) , ... vary in intensity, may be an indicator of periodic limb ... PMLD, researchers from Toledo, Ohio divided the patients into those ... 84 right-handed and 16 left-handed patients, 69% of right-handed patients ...
... PA, October 24, 2011 Nutrition Facts labels have ... these labels read in detail by consumers when making ... labels? According to a new study published in the ... Dietetic Association, consumers, self-reported viewing of Nutrition Facts ...
... for Science and Technology is the first post-secondary school to ... Experiments . Though JoVE , the first and ... video articles showing basic experimental procedures, the majority of the ... -- not the level of research one would usually associate ...
Cached Biology News:CHEST 2011: Embargoed studies highlight new sleep disorder research 2CHEST 2011: Embargoed studies highlight new sleep disorder research 3Consumers don't pay as much attention to nutrition fact labels as they think 2Consumers don't pay as much attention to nutrition fact labels as they think 3
MHC. Sections include: the isolation and functional properties of antigen-presenting cells analysis of MHC class II endocytosis and peptide turnover analysis of signalling via MHC class II molecu...
... The 1-D PAGE Cleavable ... for Targeted Protein ID ... PolyAcrylamide Gel Electrophoresis (PAGE), ... and cleavable-linker technology to ...
Supplemental reagent for annexin V assay....
Antibody Purification Specificity: Antibody Purification ...
Biology Products: