Navigation Links
OSU chemist developing solution to nerve agent exposure
Date:5/3/2011

Scientists are working to develop a new drug that will regenerate a critical enzyme in the human body that "ages" after a person is exposed to deadly chemical warfare agents.

Christopher Hadad, Ph.D., professor of chemistry at The Ohio State University (OSU), is leveraging Ohio Supercomputer Center (OSC) resources to help develop a more effective antidote to lethal chemicals called organophosphorus (OP) nerve agents.

"This project is a combination of synthetic and computational organic chemistry conducted through OSC at Ohio State, and biochemical studies conducted by colleagues at the U.S. Army Medical Research Institute of Chemical Defense at Aberdeen Proving Ground in Maryland," said Hadad.

OP nerve agents inhibit the ability of an enzyme called acetylcholinesterase (AChE) to turn off the messages being delivered by acetylcholine (ACh), a neurotransmitter, to activate various muscles, glands and organs throughout the body. After exposure to OP agents, AChE undergoes a series of reactions, culminating in an "aging" process that inhibits AChE from performing its critical biological function. Without the application of an effective antidote, neurosynaptic communication continues unabated, resulting in uncontrolled secretions from the mouth, eyes and nose, as well as severe muscle spasms, which, if untreated, result in death.

Conventional antidotes to OP nerve agents block the activity of the nerve agent by introducing oxime compounds, which have been the focus of a number of studies. These compounds attach to the phosphorus atom of the nerve agent, after the OP is bound to AChE, and then split it away from the AChE enzyme, allowing the AChE to engage with receptors and finally relax the tissues.

However, in some cases, the combined nerve agent/AChE molecule undergo a process called aging, in which groups of single-bonded carbon and hydrogen atoms called alkyl groups are removed from the molecule and a phosphonate
'/>"/>

Contact: Jamie Abel
jabel@osc.edu
614-292-6495
Ohio Supercomputer Center
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. ImaginAb, Inc. Concludes Licensing Agreement With UCLA for Novel Radiochemistry Technology
2. UC San Diego chemists produce first high-resolution RNA nano square
3. Reportlinker Adds The 2011 Clinical Chemistry and Immunodiagnostics Markets: US, Europe, Japan; Product Development Opportunities and Business Expansion Strategies for Instrument and Reagent Suppliers
4. Pharma ChemOutsourcing 2011 Unveils First Wave of 50 Biotech Chemist Speakers for September 12-15 Show in New Jersey
5. Reportlinker Adds The 2011 Clinical Chemistry and Immunodiagnostics Markets: US, Europe, Japan Product Development Opportunities and Business Expansion Strategies for Instrumentand Reagent Suppliers
6. Reportlinker Adds The 2011 Clinical Chemistry And Immunodiagnostics Markets US, Europe, Japan: Product Development Opportunities And Business Expansion Strategies For Instrument And Reagent Suppliers
7. Sigma-Aldrich Acquires Cerilliant Corporation to Strengthen its Analytical Chemistry Portfolio
8. Journal of Biological Chemistry names new editor-in-chief
9. MicroConstants Celebrates National Chemistry Week by Teaching San Diego High School Students About the Drug Development Process
10. WuXi PharmaTech Congratulates the 2010 Nobel Laureates in Chemistry
11. UCLA chemists, engineers achieve world record with high-speed graphene transistors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
OSU chemist developing solution to nerve agent exposure
(Date:4/17/2015)... , April 17, 2015  US-Australian drug discovery company, ... Memorandum of Understanding with the Feinstein Institute for ... York to collaborate with the objective ... The collaboration brings together the drug discovery ... expertise of the Feinstein Institute in neurosciences and ...
(Date:4/17/2015)... WI (PRWEB) April 17, 2015 ... sales and marketing support for the powerful Orthogonal ... the Chemical Genomics Center at the Lankenau Institute ... LCGC’s mission is to measurably improve successful drug ... HTS, by offering rare, drug-like libraries available nowhere ...
(Date:4/16/2015)... Mass. (PRWEB) April 16, 2015 ... smart data solutions driven by Semantic Web technology, ... of specialist information and services for the academic ... announced that its joint solution ‘Smart Data Lake ... a finalist for the 2015 Bio-IT ‘Best of ...
(Date:4/16/2015)... 16, 2015 Proove Biosciences , ... of BIO Contest for the 2015 BIO International ... 2015 BIO International Convention will take place June 15-18 ... the Buzz of BIO contest, industry leaders will be ... at the conference. The community voting period began on ...
Breaking Biology Technology:Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 2Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 4Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 5Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 6BellBrook Labs and Lankenau Institute Partner to Accelerate Drug Discovery using Orthogonal Pooled Screening 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3
... - Since its inception, Venture Investors has ... coasts, and it now has amassed enough capital to ... venture capital firm announced it has raised $69 million ... Early Stage Fund IV Limited Partnership, and already is ...
... Ben Liblit offers a bold prediction regarding all of the ... have bugs. All of them. Guaranteed. , ,"Software bugs are ... a University of Wisconsin-Madison computer scientist. "It is impossible with ... , Ben Liblit has developed a novel way to ...
... constant parade of start-ups came through my office showing business ... generate an income and achieve some splendid valuation. We all ... Google, and a very few others - that presented a ... that relied on other companies for their businesses, more or ...
Cached Biology Technology:Venture Investors looks to fund 20 companies 2Venture Investors looks to fund 20 companies 3Got bugs? New project lets real computer users gang up on software bugs 2Got bugs? New project lets real computer users gang up on software bugs 3Searching for revenue streams 2Searching for revenue streams 3
(Date:3/17/2015)... MINNETONKA, Minn. , March 17, 2015 /PRNewswire/ ... sciences technology company specializing in clinical study management ... will be in attendance at ARENA,s Outsourcing in ... Cary, NC.  This event provides an excellent forum ... company,s easy-to-use, flexible and affordable software-as-a-service (SaaS) eClinical ...
(Date:3/17/2015)... 2015  MecklerMedia Corporation (OTCQX: MECK) announced its ... robots ever held in New York ... 11-13, 2015 at the Javits Convention Center. ... include: Acorn Product Development; Axis NJ; c-Link Systems; ... Littler; NewBotic Corporation; Neya Systems LLC; Reliabotics; RoboKind; ...
(Date:3/12/2015)... 12, 2015 IriTech, a leading iris based ... the Texas Instruments Design Network, announced today that the ... its IriShield USB MK2120U device during a launching event ... distribution. The iris scanner is manufactured ... in India through its Indian ...
Breaking Biology News(10 mins):Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3
... to the Alps, have fascinated University of California, Berkeley, ... in a new book, " The Mountains of Saint ... a focus on Italian geologists and their groundbreaking - ... published this month by W. W. Norton & Company, ...
... Goldbergthe cartoonist who devised complex machines for simple taskswould have ... As Hinoi et al. show, the fat-derived hormone enlists the ... molecule that prods the pancreas to discharge insulin. The ... and in the December 29, 2008 print issue of The ...
... in Italy and Switzerland has shown that carbon nanotubes ... published December 21 in the advance online edition of ... step forward in the search to find ways to ... carbon nanotubes, which, like neurons, are highly electrically conductive, ...
Cached Biology News:Italy's geologic history becomes a personal tale in Walter Alvarez's new book 2Italy's geologic history becomes a personal tale in Walter Alvarez's new book 3Italy's geologic history becomes a personal tale in Walter Alvarez's new book 4Leptin's long-distance call to the pancreas 2New 'smart' materials for the brain 2
Intestinal Epithelium Differentiation Environment...
Hepatocyte Differentiation Environment...
... Useful as a positive control for ... to chromatin in vivo is a crucial ... extent of crosslinking is probably the most ... subsequent immunoprecipitation step should be taken into ...
... 300V (Cat. No. MP-300V) power supply is ... electrophoresis needs in a personal, single, easy ... power supply provides Constant Voltage or ... 4 pairs of terminator and the powerful ...
Biology Products: