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OREXIGEN(R) Therapeutics Receives Notice of Allowance for U.S. Patent Covering the Composition of Matter in OREX-003
Date:7/29/2008

e weight gain associated with atypical antipsychotics may impact compliance with treatment and, in turn, place patients at an increased risk of relapse. In contrast, staying on treatment and gaining significant body weight may place them at risk for a number of obesity-related metabolic disorders. We believe that OREX-003 has the potential to eliminate this conundrum."

Despite the commercial success of Zyprexa(R), IMS data shows that new prescriptions have declined by approximately 50% from 2003 to 2007, likely as a result of side effects, particularly excessive weight gain. According to the package insert for Zyprexa(R), 56% of patients gained 7% or more of baseline body weight in long-term clinical trials.

If issued, this patent will also cover zonisamide in combination with other atypical antipsychotics, including clozapine, risperidone, quetiapine, aripiprazole and ziprasidone. Zonisamide is also a component of the Company's obesity treatment candidate Empatic(TM), which is in the later stages of Phase II clinical development.

About Orexigen Therapeutics

Orexigen(R) Therapeutics, Inc. is a biopharmaceutical company focused on the development of pharmaceutical product candidates for the treatment of central nervous system disorders, including obesity. The Company's lead combination product candidates targeted for obesity are Contrave(R), which is in Phase III clinical trials, and Empatic(TM), which is in the later stages of Phase II clinical development. Each product candidate is designed to act on a specific group of neurons in the central nervous system with the goal of achieving appetite suppression and sustained weight loss. Beyond obesity, Orexigen is developing drug combinations for use in schizophrenia and obsessive-compulsive disorder. Further information about the company can be found at http://www.orexigen.com.

Forward-Looking Statements

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SOURCE Orexigen Therapeutics, Inc.
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