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OMT announces a breakthrough in the development of a novel human antibody platform
Date:7/23/2009

chnology create an opportunity for OMT and its new monoclonal antibody platform with unrestricted development options.

OMT's human antibody technology is the result of an improved understanding of B-cell development and a novel approach to the inactivation of endogenous antibody expression described in the "Science" article. Previously, it took either embryonic stem cells or nuclear transfer cloning -- techniques that are not available for the genetic engineering of rats to create a knockout, OMT used a new ZFN-mediated technique to generate immunoglobulin knockout rats. ZFNs are engineered proteins that induce double-strand breaks at specific sites in an organism's DNA. Such double-strand breaks stimulate the cell's natural DNA-repair pathways and can result in site- specific changes in the DNA sequence. Up to now, ZFNs have been used to edit specific genes in fruit flies, worms (C. elegans), cultured cells and zebrafish embryos, but this is the first example of successful, permanent, heritable gene-editing in a mammal.


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Contact: Dr. Roland Buelow
rbuelow@omtinc.net
650-224-6835
Open Monoclonal Technology, Inc.
Source:Eurekalert

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