NxStage Medical Provides Update on Medisystems A... (d not be relied upon as representing NxS...)

NxStage Medical Provides Update on Medisystems Acquisition

Date:8/29/2007

d not be relied upon as representing NxStage's expectations or beliefs as of any date subsequent to the date of this press release.

Additional Information About the Acquisition of Medisystems Corporation and Where to Find It

In connection with the proposed transaction described above, NxStage intends to file a proxy statement with the Securities and Exchange Commission (the "SEC"). Investors and securityholders of NxStage are urged to read the proxy statement (including any supplements) regarding the proposed transaction when it becomes available because it will contain important information about NxStage, Medisystems Corporation and related entities, David S. Utterberg and the proposed transaction.

NxStage stockholders will be able to obtain a copy of the proxy statement as well as other filings containing information about NxStage, without charge, at the SEC's Internet site (http://www.sec.gov). Copies of the proxy statement, and the SEC filings that will be incorporated by reference in the proxy statement, can also be obtained, without charge, by directing a request to NxStage Medical, Inc., 439 South Union Street, Fifth Floor, Lawrence, Massachusetts 01843 Attention: Investor Relations; telephone (978) 687-4700.

Participants in the Solicitation

NxStage, and its respective directors and executive officers, may be deemed to be participants in the solicitation of proxies in respect of the proposed transaction. Information regarding NxStage's directors and executive officers is contained in NxStage's Form 10-K for the year ended December 31, 2006 filed with the SEC on March 16, 2007 and its most recent annual meeting proxy statement filed with the SEC on April 30, 2007. These documents are available free of charge as described above.

David S. Utterberg, a director and approximate 6.7% owner of NxStage, is the direct or indirect owner of all the outstanding equity interests of Medisyst
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NxStage Medical Provides Update on Medisystems A...(d not be relied upon as representing NxS...)