Navigation Links
Nventa completes enrollment and initial dosing of second cohort in Phase 1 HspE7 safety trial
Date:12/6/2007

SAN DIEGO, CA, Dec. 6 /PRNewswire-FirstCall/ - Nventa Biopharmaceuticals Corporation (TSX: NVN) today announced that the Company has completed enrollment and initiated dosing of the second cohort of patients in its Phase 1 dose escalation trial examining the safety of its lead candidate, HspE7, in patients with cervical dysplasia, a precursor to cervical cancer. HspE7 is an investigational therapeutic vaccine targeting human papillomavirus (HPV)-related diseases. Patients in this cohort have received the first of three immunizations of 500 mcg of HspE7 with 500 mcg of adjuvant.

In addition to safety and tolerability assessment, Nventa will also collect immunological data from these patients at the end of each cohort that may provide an early indication of potential efficacy of the compound. All patients will be typed for class I and II human leukocyte antigen (HLA) subtypes, and will be evaluated for cytokine responses, anti-HspE7 antibodies and cellular (T-cell) immunology.

"We are very pleased that patient enrollment in this study has accelerated," said Peter Emtage, Ph.D., Vice President of Research and Development at Nventa. "We believe this is in recognition of the enthusiasm and support from participating clinical trial sites. With the majority of all study participants in the queue, we expect continued progress with enrollment in this Phase 1 study."

Affiliations and investigators in this trial currently include the Montefiore Medical Center; William D. Kolton, M.D. of San Diego, California; Linda Roman, M.D. of the University of Southern California (USC); Michael L. Twede, M.D. of the Salt Lake Women's Center in Sandy, Utah; and Mark T. Saunders, M.D. at the Mt. Timpanogos Women's Healthcare/Physician's Research in Pleasant Grove, Utah.

The trial is expected to dose up to 5 cohorts totaling twenty-four patients. Four cohorts will be administered 500 mcg of HspE7 and doses of 50, 500, 1,000, or 2,000 mcg of adjuvant containi
'/>"/>

SOURCE Nventa Biopharmaceuticals Corporation
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. Nventa Initiates HspE7 Phase 1 Cervical Dysplasia Trial
2. Nventa announces publication of HspE7 data
3. Nventas CEO to present at two upcoming investor conferences
4. Nventa updates progress of cervical dysplasia trial with new HspE7
5. Nventa Biopharmaceuticals Corporation announces third-quarter 2007 financial results
6. H2Diesel Completes 3 Million Gallon Per Year Pilot Facility
7. AEterna Zentaris completes management team with the appointment of Chief Medical Officer
8. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
9. Carrington Completes $8 Million Financing
10. Proteon Therapeutics Completes $12 Million Financing and Hires CFO
11. New Brunswick Scientific Completes Merger Transaction with Eppendorf
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... D.C., April 15, 2014 -- According to the ... to nuclear security comes from terrorists acquiring sufficient ... to construct a crude nuclear explosive device. The ... nuclear trafficking have involved gram-level quantities, which can ... , According to a new study appearing this ...
(Date:7/10/2014)... WASHINGTON D.C., June 17, 2014 Using microscopic ... of specific gases, researchers at MIT,s Quantum Photonics ... detection levels in the parts-per-billion range. Optical sensors ... to their high signal-to-noise ratio, compact, lightweight nature, ... optical gas sensors had been developed before, the ...
(Date:7/10/2014)... of psychiatric disorders has been extremely challenging because there ... are insufficient to cause disease. Now investigators reporting in ... Cell Stem Cell describe a strategy that ... with other risk factors or environmental exposures to affect ... a genetic variant that may predispose individuals to schizophrenia. ...
(Date:7/10/2014)... batteries that power our laptops and electric vehicles could ... charge with the help of a sponge-like silicon material. ... the graphite traditionally used in one of the battery,s ... energy storage capacity of graphite. A paper describing the ... today in Nature Communications . , "Silicon has ...
Breaking Biology Technology:Sensitive detection method may help impede illicit nuclear trafficking 2Swell new sensors 2New strategy could uncover genes at the root of psychiatric illnesses 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... of shareholder lawsuits alleging violations of federal securities law, ... has accepted the resignation of company president and ... company and served as its chief executive officer from ... interim CEO. Mike Dunham, the company's lead independent director, ...
... patent right initially goes to the inventor. But who owns ... The inventing employee? It depends on the circumstances. , ,A ... signed by the employee that includes the obligation to assign ... ,No? Then you must ask: Was the employee hired to ...
... in eBay Inc. v. Mercexchange LLC, held that whether ... an injunction must be determined under the standard four-factor ... of remedies at law; (3) balancing of hardships; and ... Circuit's approach that an injunction should be granted where ...
Cached Biology Technology:Merge president steps down in wake of shareholder suits 2Merge president steps down in wake of shareholder suits 3Who owns what invention in the workplace? 2Supreme Court decision in eBay case could affect value of patents 2
(Date:7/11/2014)... Recent evidence has demonstrated that transplantation of mesenchymal stem ... rat or mouse models of Alzheimer,s disease (AD) and ... cerebral ischemia. Few studies are reported on the therapeutic ... with AD and on the effect on oxidative injury ... Yufang Yan and her team, School of Life Sciences, ...
(Date:7/11/2014)... Evidence exists that cannabinoid receptor type 1 ... Ca2+ influx, and reduce neurotransmitter release. However, ... 1 can increase extracellular Ca2+ influx and ... his team, Tongji Hospital Affiliated to Tongji ... Technology, China used whole cell voltage-clamp and ...
(Date:7/11/2014)... Rio de Janeiro, Brazil- In the brains of ... mechanism that allows an electric or chemical signal ... another. Chemical synapses, which are the most abundant ... inhibitory. Synapse formation is crucial for learning, memory, ... and inhibitory synapses critical for brain function. ...
Breaking Biology News(10 mins):Blame it on the astrocytes 2
... tea on risk factors for heart disease has emerged ... of European Journal of Cardiovascular Prevention and Rehabilitation ... tea rapidly improves the function of (endothelial) cells lining ... in the progression of atherosclerosis. The study, performed ...
... Sensors at Your Fingertips, Literally, LOS ... Inc.,(PPS) today announces their innovative new wireless ... sale worldwide. FingerTPS,sensors are soft, flexible sensors ... tactile force data to a PC via ...
... ARGONNE, Ill. (July 1, 2008) A new, patented ... Energy,s (DOE) Argonne National Laboratory that can reliably and ... nitrogen oxide (NOx) emissions from diesel-fueled engines has been ... State start-up company with offices in Spokane and Kirkland. ...
Cached Biology News:The benefits of green tea in reducing an important risk factor for heart disease 2Wearable Sensors Conceived at Harvard Robotics Lab Measure Hand Forces 2Integrated Fuel Technologies gets worldwide license for Argonne-developed Diesel DeNOx Catalyst 2Integrated Fuel Technologies gets worldwide license for Argonne-developed Diesel DeNOx Catalyst 3
... SizeSep 400 Spun Columns, 10. *SizeSep 400 ... > 400 base pairs in length. ... CL-4B and pre-equilibrated in distilled water containing 0.15% ... than ~ 400 base pairs. *Extremely ...
... 25 purifications. Allows rapid purification ... removal of unincorporated CyDye label and ... yields of labeled cDNA probe. ... labeled by either direct incorporation or ...
... are complete ready-to-use reagents for the isolation ... specifically formulated for the isolation of genomic ... specifically formulated for the isolation of genomic ... DNAzol Reagents can be used for restriction ...
Apoptosis Detection Systems and Reagents...
Biology Products: