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Nventa Provides Corporate Update and Advancement Plans for HspE7, Hsp 6/11 and Poly-ICR
Date:10/8/2008

) and high-grade cervical dysplasia (CIN 2/3). The planned Phase 2 trials consist of multi-center, randomized, double-blind, placebo-controlled studies in the U.S., Canada, Europe and Latin America. For the CIN 2/3 study, protocol development, discussions with the U.S. Food and Drug Administration and site evaluations have been completed. A second protocol for the CIN 1 indication is near completion. Partnering or adequate financing are required for the trials to be initiated.

Poly-ICR -- Proprietary Toll-like Receptor 3 Agonist

The company's proprietary Toll-like Receptor 3 agonist, Poly-IC: Poly-Arginine (Poly-ICR), may have use as a broad immune stimulatory agent, as well as a vaccine adjuvant for both therapeutic and prophylactic vaccines. Nventa is currently advancing Poly-ICR as a means for revenue generation through partnering, as well as for its own internal development.

-- Partnering Poly-ICR -- Nventa is currently providing Poly-ICR through Material Transfer Agreements to leading vaccine developers in the U.S. and abroad who are evaluating Poly-ICR for potential incorporation into a wide range of vaccine products. Based on early interest in Poly-ICR, the company anticipates that it may provide Nventa with a near-term revenue opportunity.

-- Internal Application of Poly-ICR -- Nventa is pursuing the development of Poly-ICR for topical application for the treatment of genital warts (GW) and actinic keratosis, a premalignant condition of the skin. Next development activities include completing toxicology and formulation activities for Poly-ICR and filing an investigational new drug (IND) application for the compound. Partnering or adequate financing are required for this work to be continued.

Hsp 6/11 -- Preclinical Product Candidate for the Treatment of GW and RRP

The company has nominated Hsp 6/11 as a development candidate targeting the treatment of GW and recurrent respiratory papillomatosis (RRP), a disease in wh
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SOURCE Nventa Corporation
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