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Novogen Launches Joint Venture Aimed At Developing Drugs to Fight Ovarian Cancer
Date:11/6/2013

the first researcher in the world to isolate ovarian cancer stem cells, the cells responsible for the initial growth of ovarian tumors and their recurrence following chemotherapy.

"Around 70% of ovarian cancer patients who respond to first round chemotherapy will eventually experience tumor recurrence," Dr. Mor added. "Our research with the Novogen super-benzopyran family of drugs shows a high degree of activity against ovarian cancer stem cells where no other approach has worked in our experience to date. We believe that by combining this powerful new personalized approach with our unique drug delivery model, we may be able to treat ovarian cancer and prevent its recurrence."

Dr. Mor and his team have developed an innovative targeted delivery system for that allows the entire dose of the injected drug to reach the intended target in mice. Typically, when anti-cancer drugs are injected intravenously, approximately 3% of the drug actually reaches the tumor. With this new delivery system, it is anticipated that virtually all injected drug will reach its target.

"This joint venture with Yale brings a level of expertise, resources and firepower that is unique in the field of ovarian cancer," said Dr. Kelly. "This program will be the first in the world that I am aware of that is dedicated to finding an effective treatment for ovarian cancer, with the advantage that promising treatments are capable of being moved quickly into clinical studies in months instead of years."

The longer-term goal is to go one step further and provide personalized chemotherapy approaches that matches the best chemotherapy to the individual.

"To achieve this lofty goal, you need two fundamentals: on the one hand, the ability to extract the cancer stem cells from an individual cancer in order to assess the sensitivity of an individual tumor to drugs; on the other hand, to have the drugs that can be modified to work across individual tumor genotypes," Dr. Kelly
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