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Novexel Presents 16 Posters and one Slide Presentation at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting in San Francisco
Date:9/11/2009

azidime is very effective in two murine models of infection against a strain of Klebsiella pneumoniae harboring the KPC carbapenemase, which has been shown to confer resistance to all other beta-lactams and beta-lactamase inhibitor combinations. Poster A1-005 shows that NXL104/ceftazidime has good parenteral efficacy against Enterobacteriaceae bearing a CTX-M beta-lactamases in a mouse septicemia model. In all three models, ceftazidime alone has poor activity.

The remaining 4 posters cover in vitro studies with NXL104/ceftazidime. Poster E-194 shows that the combination was active against 300 geographically diverse clinical isolates of Pseudomonas aeruginosa while Poster E-186 shows that it had a broad spectrum of activity against resistant Enterobacteriaceae isolates. Poster E-188 and Poster E-192 examines the activity of NXL104/ceftazidime against anaerobic bacteria. In these last two posters the combination, together with metronidazole, is shown to have potent anti-anaerobe activity against most clinical anaerobe species, making it potentially useful in the treatment of mixed infections.

NXL104/ceftaroline

A final poster sponsored jointly by Novexel and Forest (B-1339a) shows the efficacy of ceftaroline combined with NXL104 against ceftaroline-resistant organisms in a mouse septicaemia model. All posters will be available for download from Novexel's web site ( http://www.novexel.com) shortly after the close of ICAAC.

In addition to these Novexel sponsored posters, 4 posters will be presented by Forest Inc on NXL104 in combination with ceftaroline. Forest licensed North American rights to develop and commercialize NXL104 solely in combination with ceftaroline in January 2008. Novexel retains rights to the NXL104-ceftazidime combination worldwide, including in North America.

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