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Novexel Presents 16 Posters and one Slide Presentation at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting in San Francisco
Date:9/11/2009

over the Phase I work with NXL103 and show that the product was generally well tolerated, that it shows a beneficial interaction with food, and that no dosing adjustment was required in elderly patients. Poster A1-1943 looks at the optimization of the ratio of linopristin and flopristin, the two components of NXL103. This study concludes that a dose consisting of 250mg of linopristin and 350mg of flopristin is optimal as it gives lower pharmacokinetic variability and delivers optimal ex-vivo plasma bactericidal activity in all subjects.

Poster E-1965 provides data on the in vitro activity of NXL103 against MRSA. The study concludes that NXL103 is highly active against important bacterial species of cSSSIs including community acquired MRSA and hospital acquired MRSA, supporting the further development of this novel streptogramin for indications such as cSSSI, where staphylococci are important pathogens.

NXL104

NXL104, either alone or in combination with ceftazidime, is the subject of 9 posters and one slide presentation.

Poster A1-007 covers a Phase I study in healthy volunteers looking at the effects of age and gender on the pharmacokinetics of NXL104. The study shows that NXL104 is well tolerated and that no dose adjustment is required based on age or gender.

Poster C1-1374 describes the nature of inhibition of the class A TEM-1 beta-lactamase by NXL104. Slide Presentation C1-1098 describes the high resolution crystal structure of NXL104 complexed with the extended spectrum beta-lactamase CTX-M-15 to understand the molecular details of mechanism of inhibition.

Three of the posters outline research with NXL104/ceftazidime in murine models of infection. Poster A1-006 shows that the NXL104/ceftazidime is efficacious in a pneumonia model using a strain of Klebsiella pneumoniae expressing elevated levels of AmpC beta-lactamase. Poster B-1339, shows that NXL104/ceft
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