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Novel electronic biosensing technology could facilitate new era of personalized medicine
Date:9/21/2010

these that could be exploited to create fast and inexpensive electronic detection techniques that don't rely on conventional labels.

"We have put together several novel pieces of nanoelectronics technology to create a method for doing things in a very different way than what we have been doing," said Muhannad Bakir, an associate professor in Georgia Tech's School of Electrical and Computer Engineering. "What we are creating is a new general-purpose sensing platform that takes advantage of the best of nanoelectronics and three-dimensional electronic system integration to modernize and add new applications to the old microplate application. This is a marriage of electronics and molecular biology."

The three-dimensional sensor arrays are fabricated using conventional low-cost, top-down microelectronics technology. Though existing sample preparation and loading systems may have to be modified, the new biosensor arrays should be compatible with existing work flows in research and diagnostic labs.

"We want to make these devices simple to manufacture by taking advantage of all the advances made in microelectronics, while at the same time not significantly changing usability for the clinician or researcher," said Ramasamy Ravindran, a graduate research assistant in Georgia Tech's Nanotechnology Research Center and the School of Electrical and Computer Engineering.

A key advantage of the platform is that sensing will be done using low-cost, disposable components, while information processing will be done by reusable conventional integrated circuits connected temporarily to the array. Ultra-high density spring-like mechanically compliant connectors and advanced "through-silicon vias" will make the electrical connections while allowing technicians to replace the biosensor arrays without damaging the underlying circuitry.

Separating the sensing and processing portions allows fabrication to be optimized for each type of device,
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Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology Research News
Source:Eurekalert  

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