Navigation Links
Novel drug discovery tool could identify promising new therapies for Parkinson's disease
Date:7/13/2009

n including involuntary shaking, slowed movement, stiffened muscles, and impaired balance. The neurons normally produce a chemical called dopamine. A synthetic precursor of dopamine called L-DOPA or drugs that mimic dopamine's action can provide symptomatic relief from Parkinson's disease. Unfortunately, these drugs lose much of their effectiveness in later stages of the disease, and there is currently no means to slow the disease's progressive course.

In most cases, the cause of Parkinson's disease is unknown, but there are recent, tantalizing clues. Investigators have discovered that vulnerable brain cells in patients with Parkinson's disease accumulate a protein called alpha-synuclein. Moreover, genetic abnormalities in alpha-synuclein cause a rare familial form of the disease. Dr. Lindquist and her team previously showed that when yeast cells are engineered to produce large amounts of human alpha-synuclein, they die.

In their new study, Dr. Lindquist and her team tested whether yeast could make cyclic peptides that would save them from alpha-synuclein's toxicity. Cyclic peptides are fragments of protein that connect end-to-end to form a circle. Although cyclic peptides are synthetic, they resemble structures that are found in natural proteins and protein-based drugs, including pain killers, antibiotics and immunosuppressants. Cyclic peptides that suppress alpha-synuclein toxicity could be candidate drugs for Parkinson's disease, or they could help researchers identify new drug targets for the disease.

"Our technique, which capitalizes on a long line of investigation in my lab, will lead to a whole new way to obtain small molecule tools useful for improving our understanding of disease mechanisms and for developing new therapies," says Dr. Lindquist. She notes that her lab and others have modeled many human diseases in yeast and in other kinds of cells.

Joshua Kritzer, Ph.D., a chemist and postdoctoral fellow in Dr. Lindquist's
'/>"/>

Contact: Daniel Stimson
stimsond@ninds.nih.gov
301-496-5751
NIH/National Institute of Neurological Disorders and Stroke
Source:Eurekalert

Page: 1 2 3 4

Related biology technology :

1. Novel method predicts impact of a covert anthrax release
2. Microbix Files First Patent Applications On Novel Technology Platform For Large Semen Sexing Market
3. Novel handheld device detects anthrax with outstanding accuracy and reliability
4. Funxional Successfully Completes Initial Clinical Trial of FX125L, an Anti-Inflammatory Drug With a Novel Mechanism of Action
5. Palkion Selects Novel Oral Development Candidate for the Treatment of Anemia
6. Clavis Pharma Raises NOK 129 Million (USD 20 Million) in a Private Placement to Fund Further Development of its Pipeline of Novel Anticancer Drug Candidates
7. Glenmarks Novel Molecule for Diabetes, Melogliptin to Enter Phase III Trials
8. Allied Minds Establishes New Company to Commercialize Novel UC Irvine Tinnitus Therapy
9. Calvert Research Licenses Novel Technology to Treat Age Related Macular Degeneration from Tulane University
10. Novavax and the NIH Agree to Evaluate a Virus-like Particle (VLP) Vaccine Candidate Against the Novel Influenza A (H1N1) Virus
11. Biomimetic-engineering design can replace spaghetti tangle of nanotubes in novel material
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... VIEJO, Calif. , Dec. 22, 2014  ( ... that CoPatient, an online medical bill review and advocacy ... offering in the FREE WellCard Savings discount health services ... medical bill that was more than they expected to ... members reduce health care costs, WellCard Savings is pleased ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... December 19, 2014 BioPlus Specialty ... pharmacies, announces the promotion of Nick Maroulis, Pharm.D. to ... Pharmacy Services. , In this position, Dr. Maroulis ... also managing the directors of our multi-site pharmacies as ... since 1997 and during that time he has served ...
(Date:12/19/2014)... , Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... today that they have been acquired by Roche (SIX: ... a privately held company that provides a big data ... sequencing (NGS) data for the academic and translational research ... Unit, and will continue to focus on development of ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... The next installment covering the enforcement tactics and proactive measures ... You or your company may have no patents and, generally, little ... a growing group of entities that consider enforcing patents to be ... and more businesses have to be concerned with patent matters. , ...
... was a tiny man with giant ideas. Ill never forget the ... 1993 at a conference of business executives in Cambridge, Massachusetts. There ... hotel. Oddly for a keynote, Drucker spoke immediately after lunch. He ... but spoke effortlessly for almost two hours. No Powerpoint. No props. ...
... Venture Capital Forum has issued an open call ... venture capitalists, corporate and private investors, and investment bankers ... is the early application deadline, and Jan. 13 is ... in the forum, which will be held at A.G. ...
Cached Biology Technology:Patent enforcement: What you don't know might hurt you 2Patent enforcement: What you don't know might hurt you 3Patent enforcement: What you don't know might hurt you 4Praise for the principles of Peter 2Praise for the principles of Peter 3Praise for the principles of Peter 4
(Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ... Market Monitor: North America Perimeter Security Systems Market" ... http://photos.prnewswire.com/prnh/20130307/600769 The North American perimeter security ... 3.6% from 2014 to 2019. Although the U.S. market ... Canada is expected to grow at a ...
(Date:12/17/2014)... 2014 Research and Markets ( ... "Samsung Galaxy S5 - Home Button Synaptics ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... technology than the iPhone 5S, Samsung introduces for ... product. The Galaxy S5 home button ...
(Date:12/17/2014)... RALEIGH, N.C. , Dec. 16, 2014 ... has licensed its PerformTek biometric technology to industry leaders ... their highly accurate, clinically validated, biometric wearable products. These ... January 6-9 in Las Vegas . ... the technology is accurate, flexible and robust – with ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... The Potato Genome Sequencing Consortium (PGSC), an international team ... has released a draft sequence of the potato genome ... Richard Veilleux, professor of horticulture in the College of ... unique phureja type of potato variety that accelerated the ...
... National Science Foundation has awarded $431,200 to the University ... facilitate the purchase of a new highly-specialized imaging system ... that will be a centerpiece of a new interdisciplinary ... Andrei Stanishevsky, Ph.D., and Yogesh Vohra, Ph.D., plan to ...
... engineers have for the first time observed and tracked E. ... similar to that of a kayak paddle. Their findings, which ... , will help lead to a better understanding of how bacteria ... from spreading. Scientists have long theorized that the cigar-shaped cell ...
Cached Biology News:Draft potato genome based on unique potato variety 2NSF funds state's first imaging system for UAB microscale research lab 2Yale engineers track bacteria's kayak paddle-like motion for first time 2
... of the Axima range, the AXIMA-CFR ... accuracy, resolution, sensitivity and mass range, ... linear and reflectron time-of-flight analysis. The ... the generation of seamless PSD, providing ...
... new MALDI O-TOF creates a new category ... orthogonal platform that has been licensed to ... of Manitoba. , As the first single ... and collisional cooling, the prOTOF 2000 represents ...
Rat Lung Fibroblasts (RLF) (>500,000 cells)...
Rat Aortic Endothelial Cells (RAOEC) (>500,000 cells)...
Biology Products: