Navigation Links
Novel drug discovery tool could identify promising new therapies for Parkinson's disease
Date:7/13/2009

Researchers funded by the National Institutes of Health have turned simple baker's yeast into a virtual army of medicinal chemists capable of rapidly searching for drugs to treat Parkinson's disease.

In a study published online today in Nature Chemical Biology, the researchers showed that they can rescue yeast cells from toxic levels of a protein implicated in Parkinson's disease by stimulating the cells to make very small proteins called cyclic peptides. Two of the cyclic peptides had a protective effect on the yeast cells and on neurons in an animal model of Parkinson's disease.

"This biological approach to compound development opens up an entirely new direction for drug discovery, not only for Parkinson's disease, but theoretically for any disease where key aspects of the pathology can be reproduced in yeast," says Margaret Sutherland, Ph.D., a program director at NIH's National Institute of Neurological Disorders and Stroke (NINDS). "A key step for the future will be to identify the cellular pathways that are affected by these cyclic peptides."

The research emerged from the lab of Susan Lindquist, Ph.D., a professor of biology at the Massachusetts Institute of Technology (MIT), a member of the Whitehead Institute for Biomedical Research, and a Howard Hughes Medical Institute investigator. Dr. Lindquist is also an investigator at the Massachusetts General Hospital (MGH)/MIT Morris K. Udall Center for Excellence in Parkinson's Research, one of 14 such centers funded by NINDS to develop treatment breakthroughs for Parkinson's disease. The study received additional funding from NIH's National Institute of Environmental Health Sciences, and from the Michael J. Fox Foundation and the American Parkinson's Disease Association.

Parkinson's disease attacks cells in a part of the brain responsible for motor control and coordination. As those neurons degenerate, the disease leads to progressive deterioration of motor functio
'/>"/>

Contact: Daniel Stimson
stimsond@ninds.nih.gov
301-496-5751
NIH/National Institute of Neurological Disorders and Stroke
Source:Eurekalert

0

GOOD

Page: 1 2 3 4

Related biology technology :

1. Novel method predicts impact of a covert anthrax release
2. Microbix Files First Patent Applications On Novel Technology Platform For Large Semen Sexing Market
3. Novel handheld device detects anthrax with outstanding accuracy and reliability
4. Funxional Successfully Completes Initial Clinical Trial of FX125L, an Anti-Inflammatory Drug With a Novel Mechanism of Action
5. Palkion Selects Novel Oral Development Candidate for the Treatment of Anemia
6. Clavis Pharma Raises NOK 129 Million (USD 20 Million) in a Private Placement to Fund Further Development of its Pipeline of Novel Anticancer Drug Candidates
7. Glenmarks Novel Molecule for Diabetes, Melogliptin to Enter Phase III Trials
8. Allied Minds Establishes New Company to Commercialize Novel UC Irvine Tinnitus Therapy
9. Calvert Research Licenses Novel Technology to Treat Age Related Macular Degeneration from Tulane University
10. Novavax and the NIH Agree to Evaluate a Virus-like Particle (VLP) Vaccine Candidate Against the Novel Influenza A (H1N1) Virus
11. Biomimetic-engineering design can replace spaghetti tangle of nanotubes in novel material
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2013)... May 16, 2013  HealthSparq, a trusted provider ... nation,s largest regional health plans, will debut a ... Plans (AHIP) Institute 2013 conference on June 13. ... showing how health insurance companies across the country ... and marketplace demands for increased healthcare transparency. ...
(Date:5/16/2013)... FL (PRWEB) May 16, 2013 As the ... to showcase their favorite Spring looks. While most make a ... season. Unfortunately, many women find the warmer weather mixes makeup ... women cope with the onset of acne during warmer months, ... from female acne treatment users the best ways to deter ...
(Date:5/16/2013)... , May 16, 2013 /PRNewswire/ ... market research report is available in ... Diagnostic Cardiac Biomarkers for Acute Coronary ... Forecasts http://www.reportlinker.com/p01182969/MediPoint-Diagnostic-Cardiac-Biomarkers-for-Acute-Coronary-Syndromes---APAC-Analysis-and-Market-Forecasts.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic ... for Acute Coronary Syndromes - APAC ...
(Date:5/16/2013)... May 16, 2013 Dr. Stephen Y. ... tutorial titled “Nanoimprint Lithography and Applications” at IEEE Nano ... Nanoimprint, invented in 1995 by Chou, is becoming one ... a unique combination of sub-10 nm resolution, large area, ... is impacting both R&D and manufacturing in a broad ...
Breaking Biology Technology:HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013 2HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013 3Adult Acne Treatment, Probiotic Action Shares New Tips for Women on How to Fight Acne While Wearing Makeup 2MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 2MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 3MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 4MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 5MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 6MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 7MediPoint: Diagnostic Cardiac Biomarkers for Acute Coronary Syndromes - APAC Analysis and Market Forecasts 8Founder, Prof. Stephen Chou to Give Tutorial on Nanoimprint at IEEE Nano 2013 2
... , EATONTOWN, N.J., July 29 ... in the emerging field of biologic products for regenerative healing, ... the Company, the French regulatory agency, afssaps, rescinded its December ... of tissue products processed from donors procured by TB OsteoCentre ...
... , VAN BUREN TWP., Mich. , ... of Ricardo plc, the leading independent provider of technology, product ... and new energy industries, has announced that the company is ... low carbon engine technologies. With the environmental demand to reduce ...
... , , SAN DIEGO, ... NBIX ) today announced new six month safety and ... using its proprietary, orally-active non-peptide Gonadotropin-Releasing Hormone (GnRH) receptor ... previously reported six month (Petal Study) and three month ...
Cached Biology Technology:Osteotech Resumes Shipments of Bulgarian Tissue 2Osteotech Resumes Shipments of Bulgarian Tissue 3Ricardo Launches Consortium to Evaluate Lubricant Challenges of Future Low Carbon Engine Technologies 2Ricardo Launches Consortium to Evaluate Lubricant Challenges of Future Low Carbon Engine Technologies 3Elagolix Successful in Six Month Lilac Petal Study; Safety and Efficacy Confirmed in Patients With Endometriosis 2Elagolix Successful in Six Month Lilac Petal Study; Safety and Efficacy Confirmed in Patients With Endometriosis 3Elagolix Successful in Six Month Lilac Petal Study; Safety and Efficacy Confirmed in Patients With Endometriosis 4
(Date:5/16/2013)... MD FASEB MARC (Maximizing Access to Research ... for The Society for Developmental Biology (SDB) 72nd ... 2013. These awards are meant to promote the ... groups into the mainstream of the basic science ... scientists at the SDB 2013 Annual Meeting. , ...
(Date:5/16/2013)... involved in neurodegenerative disease also plays a critical role ... , In a study of the common fruit fly, ... clock responsible for sleeping and waking on a 24-hour ... fly,s sleep-wake cycle is disturbed, making waking up on ... The discovery is particularly interesting because mutations in the ...
(Date:5/16/2013)... The relationship between the heritable risk for ... clear. Schizophrenia is commonly associated with cognitive impairments ... that reduced IQ may be linked to the ... ability may precede the onset of schizophrenia symptoms. ... relatives of people diagnosed with schizophrenia. , In ...
Breaking Biology News(10 mins):Gene involved in neurodegeneration keeps clock running 2Genetic risk for schizophrenia is connected to reduced IQ 2
... cancer is known to occur typically in older men. Yet ... of diagnosis. Scientists assume that these cases might be the ... cancer might be a subtype which is characterized by a ... is likely that these include a number of what are ...
... production and a growing need to find cost-effective livestock feedstuff ... the use of glycerin in swine diets. This ... Mendoza, was published in the Journal of Animal Science and ... glycerin and achieve similar performance to a conventional corn:soybean diet. ...
... The National Cancer Institute estimates that more than ... and more than 36,000 died from the disease. ... oncogene is mutated in virtually all pancreatic cancers, scientists ... pathways in humans, which make it difficult to pinpoint ...
Cached Biology News:Uncovering the genetics of prostate cancer 2Uncovering the genetics of prostate cancer 3Uncovering the genetics of prostate cancer 4University of Illinois study confirms glycerin as a feasible feedstuff for swine 2Roundworm unlocks pancreatic cancer pathway 2
14-3-3 tau Antibody Shipping Temperature: HOT Storage Temperature: -20C...
... for all tested applications). ... from within residues 500 to the C-terminus of ... is proprietary) (Peptide available as ... ID: 51043 Swiss Protein ...
Anti 7H6 Antigen (tight-junction associated protein Antigen) Monoclonal Antibody 7H6...
...
Biology Products: