Navigation Links
Novel Investigational Regimen Combining Radiation Enhancing Agent With Ibritumomab Tiuxetan (Zevalin(R)) Produces High Rate of Complete Responses in Patients With Rituximab-Refractory Follicular Non-Hodgkin's Lymphoma
Date:6/4/2008

matologic toxicities were seen. Hematologic toxicities included 29 percent grade 3/4 neutropenia, with 7 percent being grade 4, 46 percent grade 3 thrombocytopenia, and 18 percent grade 3 anemia.

For all patients (n=28), overall response and complete response rates were 57 percent and 46 percent, respectively. Median time to progression for these patients was 11 months and the two-year overall survival was estimated to be 76 percent. For rituximab-refractory follicular lymphoma patients (n=14), overall response and complete response rates were 86 percent and 64 percent, respectively. Median time to progression for this subset of patients was 14 months and the two-year overall survival was estimated to be 93 percent. Notably, responses to the MGd/Zevalin combination were seen within the first four weeks of treatment.

About Zevalin(R)

Zevalin(R) (Ibritumomab Tiuxetan) is a form of cancer therapy called radioimmunotherapy and is indicated as part of the Zevalin therapeutic regimen for treatment of relapsed or refractory, low-grade or follicular B-cell non-Hodgkin's lymphoma, including patients with rituximab refractory follicular NHL. It was approved by the FDA in February of 2002 as the first radioimmunotherapeutic agent for the treatment of NHL.

Rare deaths associated with an infusion reaction symptom complex have occurred within 24 hours of rituximab infusions. Yttrium-90 Zevalin administration results in severe and prolonged cytopenias in most patients. Severe cutaneous and mucocutaneous reactions have been reported. The most serious adverse reactions of the Zevalin therapeutic regimen were primarily hematologic, including neutropenia, thrombocytopenia, and anemia. Infusion-related toxicities were associated with pre-administration of rituximab. The risk of hematologic toxicity correlated with the degree of bone marrow involvement prior to Zevalin therapy. Myelodysplasia or acute myelogenous leukemia was observed in 2 percent of patients
'/>"/>

SOURCE Cell Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Novel Technology Breaks Through Cancer Pain
2. ThromboGenics Announces Successful Completion of Technology Transfer to Bharat Biotech for Production of Novel Thrombolytic Agent
3. XTL Biopharmaceuticals Announces Presentation of Novel Pre-Clinical Inhibitors of Hepatitis C at an Upcoming International Scientific Conference
4. Novel Angiogenic Drugs, Including a Future Blockbuster from Genzyme, Could Revolutionize Treatment of Peripheral Arterial Disease
5. New Licence for Cubicin(R) (daptomycin), the First in a Novel Class of Antibiotic, is Announced Today for the Treatment of Serious Bloodstream and Heart Infections Caused by the Most Problematic UK Organisms, Including MRSA
6. NIST team develops novel method for nanostructured polymer thin films
7. GlaxoSmithKline Awarded U.S. Department of Defense Contract to Pursue Novel Antibacterial Research Program
8. Arpida Invited to Present Preclinical Data on Novel Topical Antibiotic AR-2474 at ICAAC
9. European Expert Consortium Combines Forces to Develop a Novel Pandemic Influenza Vaccine
10. NexGenix Pharmaceuticals Enters into Exclusive World-wide License to Develop Novel Hsp90 Inhibitors
11. GenVault and the National Center for Forensic Science to Present Novel Technology for Room Temperature Storage of RNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... , Dec. 24, 2014   BioLife Solutions ... developer, manufacturer and marketer of proprietary clinical grade ... and precision thermal shipping products for cells ... it will hold its 2015 Annual Meeting of Stockholders ... Because the expected date for the Annual Meeting represents ...
(Date:12/24/2014)... MA (PRWEB) December 23, 2014 ... webinar series is designed to introduce cutting ... inform users and partners of platform upgrades. ... and benefits; empowering users in their quest ... powerful tools. , According to SoundConnect’s Marketing ...
(Date:12/24/2014)... Nashville Fertility Center announced that ... the American Society for Reproductive Medicine (ASRM), a leading ... reproductive medicine. In his new role as treasurer, ... board and will have a voice in furthering the ... supported ASRM since 1984 when he joined while conducting ...
(Date:12/24/2014)... AUSTIN, Texas , Dec. 23, 2014 /PRNewswire/ ... solutions company focused on gynecologic disease, announced today ... W. Schuler , Birchview Fund LLC and several ... million of unregistered shares of Vermillion,s common stock ... common stock in a private placement.  ...
Breaking Biology Technology:BioLife Solutions Sets Date for Annual Meeting of Stockholders 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5
... the nanoworld. In possession of alluring properties, they are ... On the plus side, they can withstand incredibly high ... Yap, an associate professor of physics at Michigan Technological ... barbecue at half of those temperatures," he says. And ...
... LAUDERDALE, Fla. , Jan. 15 InfoSpi (OTC Bulletin ... further investment for the company,s growth in the coming years. , ... Chris Hamilton views this decision. "Funding change is the ... Carbon Emissions feature so highly on the agenda of every Government, ...
... , , ANTONY, France, January 14 , - Strong Sales Growth in Q4: Up 15%, Million EUR ... MEUR %Sales Var.% ... 14 42.4 74 16, Other EU countries (2) 11.3 ... 2.0 4 45 1.5 ...
Cached Biology Technology:Harnessing the divas of the nanoworld 2InfoSpi to Create $500m Green Hedge Fund Focusing on the Carbon Credit Market 2STALLERGENES : Sales Guidance Exceeded : EUR193 Million, up 13% 2STALLERGENES : Sales Guidance Exceeded : EUR193 Million, up 13% 3
(Date:12/22/2014)... Research and Markets ( ... the "The Global Watermarking and Fingerprinting ... http://photos.prnewswire.com/prnh/20130307/600769 ... the global digital media watermarking and fingerprinting ... piracy by securely and invisibly embedding identifiable ...
(Date:12/19/2014)... Dec. 18, 2014   LaunchKey , the first ... post-password and Internet of Things era, today announced the ... venture round was led by Metamorphic Ventures with participation ... Partners, VegasTechFund, and others.  LaunchKey has raised $4 million ... expand its team and bring LaunchKey to market in ...
(Date:12/17/2014)... , Dec. 16, 2014 Research and ... the addition of the "Global Chemical Sensor ... http://photos.prnewswire.com/prnh/20130307/600769 ... the increasing demand for medical sensors in biomedical ... data for quick and correct diagnosis during surgical ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... A group of scientists at the Instituto Gulbenkian de Cincia, ... skeleton and organ size. The team, led by Florence Janody, ... the proteins that regulates the skeleton of the cell also ... and proliferation. Their findings have implications for cancer research, as ...
... University of Missouri study shows that the exposure to the ... by previous lab tests. In the study, researchers compared BPA ... with BPA throughout the day, compared to the more common ... and accumulation of BPA in the blood of mice. ...
... 5, 2011 Moisture and heat fluctuations from the ... between surface hydrology and atmospheric processes, especially those relevant ... moisture has had a positive impact on precipitation, there ... team of researchers from Columbia Engineering, Geophysical Fluid Dynamics ...
Cached Biology News:Scientists uncover role for cell scaffold in tumor formation 2Exposure to BPA has been underestimated, new MU research says 2Columbia Engineering team makes major step in improving forecasts of weather extremes 2
... derived from Paraffin embedded tissue blocks, which ... to ensure the highest quality. Tissues of ... block, sectioned at a thickness of 5 ... are large (3-5mm in diameter) in comparison ...
... Precision-designed for Optimal Microdissection , CapSure ... the precise and rapid extraction of populations ... cytology samples with Laser Capture Microdissection., ... Downstream Molecular Analysis , All CapSure LCM ...
... The new MyiQ real-time PCR detection ... detection of common green fluorescent dyes such ... system interfaces directly with the iCycler thermal ... gradient and Peltier-effect driven performance. The MyiQ ...
... are highly sensitive laser confocal systems designed ... advanced scanners that meet your expectations, differentiating ... and optimizing the signal on the bottom ... the range for increased sensitivity. Results with ...
Biology Products: