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Novel Alternative Approach to Inhibiting Insulin Growth Factor (IGF) May Provide New Treatment for Breast Cancer and Other Cancers
Date:10/24/2007

Potential to halt cancer cell growth without interfering with insulin may

address limitations of current IGF inhibitors

SAN FRANCISCO, Oct. 25 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc. (CTI) (Nasdaq and MTAX: CTIC) and Systems Medicine, LLC (SM), a wholly-owned subsidiary of CTI, announced that preclinical data presented at the 19th annual AACR-NCI-EORTC Symposium show an antibody to IGF-II may solve the problems of low blood sugar associated with drug candidates working through insulin receptor-linked pathways. The data presented is part of CTI's ongoing Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute (NCI) to develop products targeting the IGF pathway.

"While insulin-related growth factors play an important role in normal glucose metabolism and cell growth, the IGF pathway is increasingly being recognized as a critical contributor to growth of certain types of cancers," said Jack W. Singer, M.D., Chief Medical Officer of CTI. "Many of the current approaches target blocking the IGF receptor or inhibition of post receptor kinases in an attempt to slow or kill tumor cell growth and are often associated with inhibition of insulin's important metabolic functions including maintaining normal blood glucose levels. By developing an antibody that binds to and neutralizes a specific form of insulin growth factor (IGF- II) the anti-tumor benefit may be retained without blocking the insulin receptor or associated post receptor signaling pathways, potentially allowing normal blood glucose and metabolic control."

Depleting soluble ligand (IGF-II) in solid tumor (human breast cancer xenograft) by ligand-specific human monoclonal antibody (Abstract #A59)

Dimiter S. Dimitrov, Ph.D., Head of the Protein Interaction Group of the CCR Nanobiology Program at the NCI's Center for Cancer Research and principal investigator for the NCI on the CRADA, presented data that may provide the first pro
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SOURCE Cell Therapeutics, Inc.
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