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Novel ACR Hybrid Score in Rheumatoid Arthritis Applied for the First Time to Data from the RAPID 1 Study with Cimzia® (certolizumab pegol)
Date:5/16/2011

BRUSSELS, May 16, 2011 /PRNewswire/ -- The ACR hybrid score, a new measure of response to RA treatment recently developed by the American College of Rheumatology, demonstrated improved sensitivity compared to traditional ACR responses, according to recently published results in Arthritis Care & Research. Traditional ACR20/50/70 and DAS28 scores were compared to the ACR hybrid score in a post-hoc analysis of the RAPID 1 study, the first clinical trial data to be analyzed using the ACR hybrid score.

"The ACR hybrid score suggested similar results to other standard outcome measures, in that certolizumab pegol treated patients had significantly higher improvement in signs and symptoms of RA over placebo", said Dr. R.F. van Vollenhoven from the Karolinska Institute in Stockholm, Sweden and lead author of the publication. "These results are of interest because the ACR hybrid score may represent a more sensitive and accurate measure of RA treatment response than the current accepted standard and could be considered as a valuable primary end point in future clinical trials."

The ACR hybrid score combines conventional ACR20/50/70 scores with the mean percent change in all 7 ACR core components, providing a percent improvement from baseline on a continuous scale.  The post hoc analysis of the ACR hybrid scores were from RAPID 1 (Rheumatoid Arthritis Prevention of structural Damage), a phase III double-blind placebo-controlled trial designed to establish the efficacy and tolerability of certolizumab pegol together with methotrexate (MTX), in the treatment of active RA in patients who did not adequately respond to conventional treatment.

The use of the ACR hybrid score was evaluated relative to other measures of response, including the ACR20/50/70 response rates and changes in DAS28 (disease activity score), and analyses differences between active treatment and placebo, elements that may be underestimated using ACR20/50/70 respons
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