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Novartis launches the Cancer Cell Line Encyclopedia to catalog world's cancer cell lines
Date:4/3/2012

er Cell Line Encyclopedia will provide scientists with the ability to build predictive models of what types of patients will respond to a particular class of drugs."

The cell lines were acquired from commercial vendors in the U.S., Europe, Japan and Korea and represent a diverse picture of cancer as a disease as they include many subtypes of both common and rare forms of cancer. According to lead authors and NIBR researchers Jordi Barretina and Giordano Caponigro, each cell line was genetically characterized through a series of high-throughput analyses at the Broad Institute, including global RNA expression patterns, changes in DNA copy number, as well as DNA sequence variations in about 1,600 genes associated with cancer, and pharmacologic profiling for several drugs in about half of the cell lines. Algorithms were developed to predict drug responses based on the genetic and molecular makeup of cancer cells.

Pairing this information with ways to rapidly genotype patient tumor samples represents the next step in the effort to enable the personalization of cancer treatment. Some major research hospitals already routinely genetically profile cancer patients' tumors, and many more are likely to follow, according to the researchers.


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Contact: Mariellen Gallagher
mariellen.gallagher@novartis.com
617-909-9137
Novartis Institutes for BioMedical Research
Source:Eurekalert

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