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Novartis launches the Cancer Cell Line Encyclopedia to catalog world's cancer cell lines
Date:4/3/2012

  • Collaboration with the Broad Institute yields comprehensive encyclopedia of genetic and molecular information for nearly 1,000 cancer cell lines

  • Encyclopedia, publicly available, may improve the design of cancer trials and advance cancer research

  • Data from encyclopedia may help researchers identify patients who could most benefit from any given drug

Basel, March 28, 2012 Novartis and the Broad Institute have developed a cancer cell line encyclopedia that catalogues the genetic and molecular profiles of almost 1,000 human cancer cell lines used in drug research and development. Results of the collaboration, published in the journal Nature and released in advance online today, may allow scientists around the world to use this information to improve cancer clinical trial design and further cancer research.

"Cancer is a genetic disease. Cell lines reflect the genetic disturbances that drive cancers. Probing cell lines with medicines targeted at specific pathways, as done for the Cancer Cell Line Encyclopedia, provides a powerful tool for design of cancer treatment," said Mark Fishman, President of the Novartis Institutes for BioMedical Research (NIBR). "We are placing this information in the public domain. We hope that many in industry and academia will use these data to discover new drug targets, to evaluate current therapies, and to facilitate treatment for their patients with cancer."

The genetic and molecular profiling data from the cell lines is freely available to the scientific community here on the Broad Institute's website.

Investigators use cell lines to shed light on how new or existing cancer drugs might best be used in patients. "Without access to a systematically collected set of molecular data, researchers can't match experiments from cell lines with patient tumors when new medicines become available," said William Sellers, Global Head of Oncology, NIBR. "The Canc
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Contact: Mariellen Gallagher
mariellen.gallagher@novartis.com
617-909-9137
Novartis Institutes for BioMedical Research
Source:Eurekalert

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