Date:4/1/2009

logical efficacy in-vivo in treating subcutaneous dermatophyte infections based on an established animal model. Importantly, these data combined with the past preclinical work that showed NVC-422 kills P. Acne, in the follicle, strongly suggest that NVC-422 may be a potent and well-tolerated treatment for acne and other numerous serious skin infections.

• Hospital infections: In May 2008, NovaBay successfully completed a Phase I trial that showed NVC-422 was well tolerated in the bladder as a lavage solution for catheterized patients. In November 2008, the company commenced patient enrollment in a Phase II exploratory study of hospitalized patients who are catheterized and have bacteriuria. Data from this ongoing study, which is expected later this year, if positive, will provide support for future development plans for catheter-associated urinary tract infections, the most common hospital-acquired infection.

• Respiratory infections: In May 2008, NovaBay completed its Phase IIa study of NVC-422 for nasal decolonization of Staphylococcus aureus, including MRSA (Methicillin Resistant Staphylococcus Aureus). In this study, two concentrations of a prototype nasal spray formulation of NVC-422 were tested to decolonize the lower nasal passages and were both found to be well tolerated. Based on a statistical analysis the higher dose treatment group provided consistent S. aureus reduction below the baseline score throughout the treatment period.

• Intellectual property: NovaBay continues to solidify and expand its proprietary position in the Aganocide compounds and related antimicrobial technologies. NovaBay's key composition of matter patent for Aganocide compounds, including NVC-422, was issued by the U.S. Patent and Trademark Office
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SOURCE NovaBay Pharmaceuticals, Inc. Copyright©2009 PR Newswire. All rights reserved

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