Navigation Links
Nile Therapeutics, Inc. Announces Dosing of First Patient in Phase 2 Study of CD-NP for the Treatment of Acute Heart Failure
Date:8/4/2009

SAN FRANCISCO, Aug. 4 /PRNewswire-FirstCall/ -- Nile Therapeutics, Inc. (Nasdaq: NLTX), a company focused on the development of novel therapeutics for heart failure patients, today announced dosing of its first patient in a Phase 2 clinical study of its lead product, CD-NP, for the treatment of acute heart failure.

The single-blind, placebo-controlled Phase 2 study is designed to provide additional information on the safety and tolerability of CD-NP when infused for up to 72 hours in patients with acute heart failure and mild to moderate renal insufficiency. Additional exploratory endpoints will include assessments of CD-NP's ability to relieve symptoms of acute heart failure and its effects on biomarkers of heart failure and renal function. The study is expected to enroll approximately 30 to 40 patients in the United States, Germany and Israel and will examine up to 3 doses of CD-NP.

"Currently there is a significant unmet need in acute heart failure for treatments that can both relieve symptoms and also preserve or enhance renal function in these patients," said Dr. James Young, MD, George & Linda Kaufman Chair and Professor, Cleveland Clinic, and the principal investigator on the study. "The potential of CD-NP to meet both of these objectives is a compelling scientific story, and is of particular clinical importance for the approximately two-thirds of heart failure patients with pre-existing renal dysfunction."

Previously reported results of a Phase 1b study in chronic heart failure patients showed that CD-NP infusion was associated with an improvement in renal function. Previously reported interim results from the first cohort of a Phase 2a study in patients hospitalized for acute heart failure also showed that CD-NP infusion was associated with clinically meaningful improvements in car
'/>"/>

SOURCE Nile Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. Cell Therapeutics, Inc. Announces Exercise of Overallotment
2. Cell Therapeutics, Inc. Announces Pricing of Public Offering of Common Stock and Warrants
3. Nile Therapeutics, Inc. Completes $3.4 Million Private Placement
4. Oxygen Biotherapeutics, Inc. Announces Closing of Private Placement Financing Agreement
5. Nile Therapeutics, Inc. To Raise $3.4 Million in Private Placement
6. Intarcia Therapeutics, Inc. Presents ITCA 650 Phase 1b Study Results as a Late-Breaker at the American Diabetes Association 69th Scientific Sessions
7. Intarcia Therapeutics, Inc. Announces Acceptance of ITCA 650 Phase 1b Study for Late-Breaker Presentation at the American Diabetes Association 69th Scientific Sessions
8. Prospect Therapeutics, Inc.s GCS-100 Inhibited Blood Vessel Formation in a Variety of Cancer Models
9. Cell Therapeutics, Inc. (CTI) to Present at 2009 BIO International Convention
10. Prospect Therapeutics, Inc. Assigns All Its Assets to Joseph F. Finn, Jr., C.P.A. for the Benefit of Its Creditors
11. Cell Therapeutics, Inc. (CTI) to Report 2009 First Quarter Financial Results on May 7

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/25/2009)...at Economic Club of Canada , ...mbassador to Speak at Economic Club of Canada., , ...ernational Investment, and Chairman and CEO of the...avid Appia go to www.investinfrance.org . , , ,W...ress to discuss recent pro-business initiatives ad...
(Date:11/25/2009)...-ArdeaBiosciences,Inc.(Nasdaq: RDEA )announcedtoda...iveofficer,willpresentatthePiperJaffray21stAnnualH...ollows:,PiperJaffray21stAnnualHealthCareConferenc...Time,Location:TheNewYorkPalaceHotel,NewYork,NY,Web...arget=,_blank,title=,http://www.corporate-ir.net/i...
(Date:11/24/2009)...womoreprestigiousuniversitieshavejoinedBioCareerCe...eforlifescienceprofessionals. ,, Northwesternan...ing28othermajorlifesciencetrainingInstitutions. ,...rpost-graduatesinthelifesciences.Whiletherearehund...rCenteristheonlyonethatserveslifesciencepost-gradu...
(Date:11/24/2009)...e-FirstCall/--deCODE,genetics,Inc.(Nasdaq: DCGN )t...nsbytheU.S.BankruptcyCourtfortheDistrictofDelaware...arypetitionfor,reliefunderChapter11oftheUnitedStat...eordersissuedbytheBankruptcyCourtallowthecompanyto...ceedings.Inparticular,the,companyreceivedinterimBa...
Breaking Biology Technology:French Ambassador for International Investment to Visit Toronto December 11 2Ardea Biosciences to Present at the Piper Jaffray 21st Annual Health Care Conference 2Two Major Universities Join Nation's Leading Postgrad Bio Job Board 2deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 2deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 3
...- William R. Hendee will retire effective June 30 ...ces at the Medical College of Wisconsin , and dev...nal. , ,Hendee, who also will retire as president ...rement on June 19. While the Medical College condu... is likely to look inside the organization for int...
...e to the Wisconsin State Senate five years ago, ... done little to transform its economy from an old ...el favoring innovation and ideas. , ,Simply put, t... at the expense of creating new ones. The lack of ...f the line when it came to capital formation and j...
...mpanies that ranked among the best places to work ...eld are ranked highly because they offer employee ... job satisfaction. , , Northwestern Mutual Life I...ce Group , Madison, and Schneider National Inc. ,...f America,s top 100 companies complied by Compute...
Other Biology Technology:Medical College grad school dean Bill Hendee to retire 2It's time for Wisconsin's economy to grow 2It's time for Wisconsin's economy to grow 3Wisconsin companies among Best IT Workplaces 2
(Date:11/24/2009)...rican College of Medical Toxicology (ACMT) have si...n of the Journal of Medical Toxicology (JMT), th... 2010. It was previously published by the Univers...dical Toxicology , an international, peer-reviewed...d practice of medical toxicology. The quarterly j...
(Date:11/24/2009)...mber 24, 2009) New research on bacterial communit...eveals predictable temporal patterns, suggesting t...ers for monitoring climate change in the polar reg...edings of the National Academy of Sciences Early ...ix rivers shifted synchronously over time, correla...
(Date:11/23/2009)... November 23, 2009 Applied mathematicians dissec...ncifolia ), a characteristic long leaf with a sadd...along the edges. The simple cause of the lily,s fa...ing during differential growthwas revealed by usin...bons. , Haiyi Liang, a postdoctoral student at H...
Breaking Biology News(10 mins):Springer and the American College of Medical Toxicology to work together 2Researchers establish common seasonal pattern among bacterial communities in Arctic rivers 2The cause behind the characteristic shape of a long leaf revealed 2Beazley Expands Healthcare Team with Appointment of Tom McNally 49634 1Beazley Expands Healthcare Team with Appointment of Tom McNally 49634 2Seroquels First and Second Line Patient Share Has Grown Since Last Years Analysis of Prescribing Trends in Bipolar Disorder 49629 1Seroquels First and Second Line Patient Share Has Grown Since Last Years Analysis of Prescribing Trends in Bipolar Disorder 49629 2Seroquels First and Second Line Patient Share Has Grown Since Last Years Analysis of Prescribing Trends in Bipolar Disorder 49629 3Unspoken memories of Holocaust survivors find silent and nonpathological expression 49625 1Unspoken memories of Holocaust survivors find silent and nonpathological expression 49625 2
..., R.I. [Brown University] Brown University, with ...and, has been awarded a $12-million, five-year con...Children,s Study, a groundbreaking research projec... Institute of Child Health and Human Development (...e National Institutes of Health, announced the awa...
...very that counters prevailing thought, a study in ...es involved in "fat-burning" can actually increase...esity. These unusual findings, appearing this week...ght-loss therapy. , Humans and other warm-bloode...to maintain body temperature, and it,s currently b...
... are known as a keystone species, filling such an ...them, entire ecosystems can collapse. Scientists a... farther-reaching effects that extend to terrestri...op predator: the bald eagle. , In nearshore mari... 250 feet and function much like trees in a forest...
Other Biology News:Brown University and Women & Infants Hospital expand national children's study to Bristol County 2Brown University and Women & Infants Hospital expand national children's study to Bristol County 3Brown University and Women & Infants Hospital expand national children's study to Bristol County 4Making metabolism more inefficient can reduce obesity 2Decline in Alaskan sea otters affects bald eagles' diet 2Decline in Alaskan sea otters affects bald eagles' diet 3
...-HODE-d4 contains 4 deuterium atoms at the 9, 10, ... internal standard for the quantification of 9(S)-...produced by the lipoxygenation of linoleic acid in...atherosclerotic plaques, as an esterified componen...
12(S)-HETE-d8, Deuterium Conjugated/Tagged from Cayman Chemical
Silencer Pre-designed siRNA, HPLC purified, annealed from Ambion
Silencer Pre-designed siRNA, HPLC purified from Ambion
Biology Products: