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Nikon Instruments Launches Fully-Automated A1 Confocal Laser Microscope Series
Date:1/29/2008

P increases sensitivity by using a pair of integrating digitizers to assure data is gathered over the full pixel period. The fiber-optic communication data transfer system can move data at a maximum of four giga bites per second - 40 times faster than the previous method. This allows transfer and recording of image data (512 x 512 pixel images) in five modes at more than 30 fps.

An exclusive low-angle incidence dichroic mirror realizes 30% increase of fluorescence efficiency. Additionally, brighter images are obtained with the industry's first continuously variable hexagonal pinhole, which replaces the standard four-sided aperture. With the hexagonal pinhole, maximum confocality is maintained while achieving higher brightness equivalent to that of an ideal circular pinhole.

"The A1R model defines a new level of scanning control with resonant and galvanometer scanners that can be used simultaneously and at significantly improved speeds," said Stan Schwartz, vice president of Nikon Instruments. "We've incorporated faster scanning speeds, unique photo-activation and simultaneous image detection, all with improved sensitivity and reduced photo- toxicity effects, to achieve a high-performance live-cell confocal imaging system with a full range of application modalities and user defined work flow. When used with the Ti series of inverted microscopes, the A1 offers a complete confocal system that is an ideal platform for a variety of high-level techniques in principal investigator labs and core imaging facilities alike."

The A1 series is available with or without a resonant scanner, depending on imaging needs. The A1R includes both galvanometer scanners, which acquire up to four fps, and a resonant scanner. The resonant scanner acquires 30 fps at 512 x 512 pixel resolution and as many as 230 fps in the 64 line band scan mode. It also allows for either simultaneous and sequential photo-stimulation or bleaching or image acquisition revealing high tempora
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SOURCE Nikon Instruments, Inc.
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