The following scientific talks are among those that will be presented by researchers from the U.S. Department of Energy's Brookhaven National Laboratory at the American Physical Society meeting, March 10-14, 2008, at the Morial Convention Center, New Orleans, Louisiana. Please note that the content of each talk is embargoed until the time of that talk as noted below. All of the research described below was funded by the Office of Basic Energy Sciences within the U.S. Department of Energy's Office of Science.
DNA-Guided Nanoparticle Assembly
Part 1: Embargoed for release on Monday, March 10, 2008, 8:12 a.m. Central Time (9:12 a.m. Eastern)
Brookhaven Lab scientists have developed a new method for controlling the self-assembly of nanometer and micrometer-sized particles. Based on designed DNA shells that coat a particle's surface, the method can be used to manipulate the structure of numerous materials. Such fine-tuning of materials at the molecular level may lead to numerous applications, including cell-targeted systems for drug-delivery and bio-molecular sensing for environmental monitoring or medical applications.
"Our method is unique because we attached two types of DNA to the particles' surfaces," said Brookhaven researcher Dmytro Nykypanchuk, who will give a talk about this work on Monday, March 10, at 8:12 a.m. Central Time in room R06. " The first type of DNA forms a double helix, while the second type is non-complementary, neutral DNA, so it provides a repulsive force. The addition of the repulsive force allows for regulating the size of particle clusters and the speed of self-assembly with more precision."
Part 2: Embargoed for release on Wednesday, March 12, 2008, 4:30 p.m. Central Time (5:30 p.m. Eastern)
In subsequent experiments, the researchers used DNA to guide the creation of three-dimensional, ordered, crystalline structures of nanoparticles. Engineering such 3-D structures is important f
|Contact: Karen McNulty Walsh|
DOE/Brookhaven National Laboratory