Navigation Links
Newly designed molecule blocks chlamydia bacteria
Date:7/20/2011

er the whole cell and prevents it from mounting an effective, pathogen-killing immune response," Valdivia said. "Chlamydia is unique among pathogens, in that it can co-exist within humans without causing symptoms for a long time. This reflects a careful balance between the host and the pathogen. We think CPAF is central to this balance. Therefore, if we disarm it, we can tilt the equation toward the human host and mount an effective immune response that will not only clear the infection but prevent it from re-emerging."

The Duke chemists, led by Dewey McCafferty, Ph.D., a professor in the Duke Departments of Chemistry and Biochemistry, designed a molecule that could block the CPAF activity inside of human cells.

"Typically, to design a potent, specific, and cell-permeable inhibitor is a complicated undertaking and inhibitor designs don't work right away," McCafferty said. "But in this case, it worked on the first try. Professor Valdivia's group of microbiologists and my group of chemical biologists worked to establish which qualities we needed to incorporate into a CPAF inhibitor. The results are very exciting, because we have an inhibitor lead molecule that may form the basis for a new class of anti-Chlamydial drugs."

They found that when CPAF was blocked over time by their designed molecule, the protective home that the bacteria make for themselves within the infected cells degraded, and CPAF no longer could degrade the proteins in the cell that would normally mount an immune response to the infection.

When CPAF is inhibited, the infected human cells effectively "commit suicide," Valdivia said. "When the infected human cell dies, so does Chlamydia, and this ends the infection."

Valdivia said that the findings could yield new therapeutic approaches that might turn a natural infection into a vaccination.

"By stopping the cloaking response of the bacteria, we are essentially revealing where they ar
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Human Trial Results Show Plant Extract Tops Drug at Regulating Blood Sugar Levels; Huge Market Seen for Newly Developed Food Additive Emulin™
2. Newly Integrated Software Suite From ZS Associates Offers Comprehensive Set of Sales Performance Management Software Solutions
3. China Sky One Medical, Inc. Starts Production at Newly Acquired Facility and Reaffirms Guidance
4. Prometheus Strengthens Intellectual Property Portfolio with Newly Issued Patents for Thiopurine Metabolite Testing
5. Newly Available To Medical Device Manufacturers - Bluetooth Testing Equipment
6. First U.S. Implants of Newly Approved Embozene(TM) Color-Advanced Microspheres Embolization Platform
7. Newly Available To Medical Device Manufacturers - Bluetooth Testing Equipment
8. Hospira Supports Newly Introduced Biogenerics Legislation
9. febit First to Offer Newly Published Mouse Genome on a Chip for DNA/RNA Detection and Enrichment
10. Titanium and Aluminum Distributor, Trans World Alloys Relocates to Its Newly Built, State-of-the-Art Headquarters in Gardena, California
11. RBC Life Sciences Fills Newly Created Vice President of Sales and Marketing Position With Industry Veteran
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... SAN DIEGO, July 30, 2015   Senomyx , ... proprietary taste science technologies to discover, develop, and commercialize ... supply industries, today reported financial results for the second ... half of 2015, we remain on track to achieve ... and Chief Executive Officer of the Company. "Since our ...
(Date:7/30/2015)... 30, 2015  Discovery Laboratories, Inc. (Nasdaq: ... the second $1.0M tranche under a previously awarded ... valued at up to $3.0 million to support ... as a potential medical countermeasure to mitigate acute ... awarded an initial $1.0 million under this grant ...
(Date:7/29/2015)... 2015 Sanofi, un leader ... résultats pour le premier semestre 2015. Le Directeur ... Visionner l,interview vidéo et lire la ... Au sommaire de l,interview :  ... croissance - Diabète - ...
(Date:7/29/2015)... , July 29, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: ... , the Company,s Chief Financial Officer has resigned.  The ... Chief Financial Officer who retired in December 2014, as ... for a permanent successor.     Andy Ashworth ... Laurin and ensure a smooth transition.  Andy was the ...
Breaking Biology Technology:SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 5SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 6SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 7SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 8SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 9Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3BioAmber Announces Change in Chief Financial Officer 2BioAmber Announces Change in Chief Financial Officer 3
... begun using a network infrastructure developed by Citrix ... over the Internet from a central office, the company ... able to provide 1,600 government employees across 45 departments ... from remote locations, including their homes, according to a ...
... - Working to help cell-phone users take advantage of ... University of Wisconsin-Madison engineers have developed a device that ... on even less battery power. , ,"When you've been ... you can feel how hot it gets," notes Zhenqiang ...
... an Internet search page: top, middle and down. A search ... times its 100 feet long. Today, e-commerce is like a ... then will it will float on the surface and be ... submarine, it will stay caught in some mysterious undercurrents or ...
Cached Biology Technology:Dane County improves law enforcement and community services 2UW-Madison technology to advance cell phones 2UW-Madison technology to advance cell phones 3Does your web site have visibility? 2Does your web site have visibility? 3
(Date:7/27/2015)... 27, 2015   Zynx Health ™, the ... improvement solutions, today announced that its ZynxCarebook ... on Android smartphones and tablets. With this expansion, ... can use ZynxCarebook to securely exchange messages and ... care transitions to other care settings, and improve ...
(Date:7/21/2015)... 2015 Passwords have proven futile for ... recent U.S. Office of Personnel Management breach. Biometric ... conundrum, but developers and end-users are concerned about ... dilemma, Biometrics-as-a-Service provider HYPR Corp. announced today the ... third party integration. A video ...
(Date:7/9/2015)... 2015 Research and ... the "Biometrics for Banking; Market & Technology ... to their offering. The adoption for ... growth and the forecast is that by 2020 ... companies involved in delivering biometric systems to the ...
Breaking Biology News(10 mins):Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3
... Ground-breaking research from Professor Douglas Kell, published in the ... the majority of debilitating illnesses are in part caused ... toxins that can react with the components of living ... diseases of many kinds in different parts of the ...
... N.Y. Pankaj Karande, a Rensselaer Polytechnic Institute assistant ... new generation of scientists and engineers developing exciting and ... complex brain illnesses, including Alzheimer,s disease, Parkinson,s disease, traumatic ... attracted the interest of the Goldhirsh Foundation and now ...
... The University of Pennsylvania, Dr. Ron Koder, assistant professor of ... of a team that devised a novel method for producing ... neuroglobin. He was recently awarded a three-year $1.3 million ... artificial blood that can be administered to injured troops on ...
Cached Biology News:See off Alzheimer's with the color purple 2Delivering drugs to the brain: New research into targeted treatment of Alzheimer's 2Delivering drugs to the brain: New research into targeted treatment of Alzheimer's 3CCNY professor gets grant to develop 'artificial blood' 2
Supplemental reagent for annexin V assay....
Conjugate Quality Control Evaluation Specificity: Conjugate Quality Control Evaluation ...
Ultra-sensitive, non-radioactive detection of rat Big Endothelin-1 (Big ET-1)...
... Peptide Antigen Design , Customer Peptide Synthesis , ... above 90% , 20 mg will return to customer ... Rabbits x 2 , Maintenance 102 days/each ... Immunizations/Boost injections x5 /each , Test ...
Biology Products: