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Newly-Published Study Compares SURFAXIN LS™ and CUROSURF® in Well-Established Model of Respiratory Distress Syndrome
Date:5/9/2012

ith Curosurf-treated lambs (p < 0.05). 
  • In contrast to lambs treated with SURFAXIN LS, lambs treated with Curosurf experienced significant reductions in heart rate and rapidly increased brain oxygenation during the peridosing period (p < 0.05).
  • The investigators concluded that SURFAXIN LS may enable ventilation at lower mean airway pressures, thereby potentially reducing the incidence of chronic lung disease, and as such may be an effective substitute for the currently-marketed surfactant products.
  • Dr. Russell G. Clayton, Senior Vice President, Research & Development of Discovery Labs commented, "The observations in this study suggest that SURFAXIN LS may reduce potentially unfavorable responses to surfactant administration.  These study results, when combined with the anticipated flexibility and ease of use benefits, suggest that SURFAXIN LS potentially represents a meaningful improvement in this class of drugs."

    On March 6, 2012, the FDA granted marketing approval for SURFAXIN (lucinactant) for the prevention of RDS in premature infants at high risk for RDS.  SURFAXIN provides U.S. healthcare practitioners with an alternative to the animal-derived surfactants that today are the standard of care to manage RDS in premature infants. While SURFAXIN is stored and delivered in a liquid dosage form, SURFAXIN LS is stored as a powder and re-suspended to liquid form prior to use, eliminating the need for refrigerated storage.  Discovery Labs is implementing a development plan intended to gain marketing authorization for SURFAXIN LS in the U.S., the European Union and other major markets worldwide.

    Dr. Clayton continued, "Our development strategy for SURFAXIN LS is to build upon the SURFAXIN clinical experience and advance a dosage form that will improve ease of use of surfactant administration for healthcare practitioners, as well as potentially prolong shelf life and eliminate the n
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    SOURCE Discovery Laboratories, Inc.
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