Navigation Links
NewLink Initiates Pivotal Phase 3 Clinical Trial of HyperAcute(R)-Pancreas Immunotherapy for Resected Pancreatic Cancer
Date:5/27/2010

ed into the human body. The response is strong enough to destroy transplanted cells and tissues within hours. NewLink's HyperAcute immunotherapy exploits this hyperacute antigen-antibody response to educate a patient's immune system to attack and destroy the patient's own unmodified cancer cells.

The company's HyperAcute products are composed of irradiated, allogeneic (off the shelf), whole cancer cells that have been genetically modified to add alpha-Gal residues to cell-surface lipids and proteins. The alpha-Gal epitopes function as a molecular adjuvant, effectively harnessing the xenotransplant rejection mechanism.

About HyperAcute-Pancreas Immunotherapy

HyperAcute-Pancreas immunotherapy consists of two equal cell doses of allogeneic pancreatic cancer cell lines engineered to express the murine alpha-Gal gene. Although cells making up naturally occurring pancreatic tumors in patients do not express alpha-Gal, they share other molecules including new tumor-specific and tumor -associated antigens, with the genetically altered pancreatic cancer cells introduced by the immunotherapy. Those similarities are believed to allow the antibodies and immune cells targeting alpha-Gal to redirect their attack and destroy patient's own tumor cells.

About Pancreatic Cancer

Cancer of the pancreas is the fourth leading cause of cancer death in the United States, killing more than 35,000 Americans in 2009. The disease is divided into two broad subtypes based on histological classification: pancreatic endocrine tumors are diagnosed in 5 percent of cases, and pancreatic adenocarcinoma accounts for the remaining 95 percent. Incidence and age-adjusted mortality rates of pancreatic adenocarcinoma are nearly equal, meaning the disease is almost universally fatal. Pancreatic cancer is
'/>"/>

SOURCE NewLink Genetics
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. NewLink Genetics Corporation Closes $7.5 Million Financing
2. NewLink Genetics to Present Phase 2 Data on HyperAcute(R)-Pancreas Immunotherapy at the American Society of Clinical Oncology Annual Meeting
3. Romark Initiates Clinical Trial of Alinia(R) for Chronic Hepatitis C in the United States
4. Dawson James Securities Initiates Research Coverage on CryoCor, Inc. (Nasdaq: CRYO) with a Strong Buy Rating and $6.00 Target Price
5. Spectrum Pharmaceuticals Initiates Second Registrational Phase 3 Clinical Trial for EOquin(R) in Patients With Non-Invasive Bladder Cancer
6. XTL Biopharmaceuticals Initiates Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain
7. Nventa Initiates HspE7 Phase 1 Cervical Dysplasia Trial
8. Cytochroma initiates Phase I/II clinical trial of CTAP101 Capsules for vitamin D insufficiency in chronic kidney disease
9. Arena Pharmaceuticals Initiates Second and Third Pivotal Trials Evaluating Lorcaserin for the Treatment of Obesity
10. GeneNews initiates patient sample accrual for validation studies of colon cancer blood test
11. Human Genome Sciences Initiates Second Randomized Phase 2 Trial of HGS-ETR1 in Combination With Chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... September 22, 2014 Pearl's Premium Ultra ... in drought tolerant grass seed this week with the ... The announcement coincides with the fact that it is ... as many believe. , As of the date ... favorable reviews by industry experts and the media including: ...
(Date:9/22/2014)... components developed by researchers at the USC Viterbi ... build a 3-D microfluidic system quickly and cheaply ... , Microfluidic systems are used in many ... manipulate small volumes of fluids for use in ... detection, clinical diagnostic testing, and synthetic chemistry. Traditionally, ...
(Date:9/22/2014)... have generated a new star-shaped molecule made up of interlocking ... created. , Known as a ,Star of David, ... a quarter of a century and the team,s findings are ... Consisting of two molecular triangles, entwined about each other three ... each triangle is 114 atoms in length around the ...
(Date:9/22/2014)... Washington D.C. (PRWEB) September 22, 2014 ... and Georgetown President John DeGioia on Friday renewed ... understanding for an additional five years to expand ... security, biosecurity, nonproliferation and global climate, energy and ... expansion of an MOU originally signed in December ...
Breaking Biology Technology:Pearl's Premium Ultra Low Maintenance Lawn Seed Announces A Major Breakthrough In Drought Tolerant Grass Seed 2Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 2Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 3Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 4Lego-like modular components make building 3-D 'labs-on-a-chip' a snap 5Lawrence Livermore Renews Pact with Georgetown University to Expand Research and Education in Science and Policy 2
... insiders knowingly misrepresented the ... company ... Shapiro filed a,proposed class-action lawsuit on behalf of CellCyte Genetics ... company and chief executive officer Gary A.,Reys, background, causing company ...
... Jan. 18 Brinks Hofer Gilson & Lione, one ... States, is,pleased to announce that 21 of its attorneys ... survey conducted by Law & Politics magazine.,Additionally, 11 Brinks ... Martin Addy, chair of the Appellate Group at Brinks, ...
... Record 20 Million Signatures Collected on myLifetime.com in ... Bipartisan Breast Cancer Patient Protection Act Allows Women Choice to, Recuperate ... ... Cancer Surgery -, NEW YORK, Jan. 18 "Desperate ...
Cached Biology Technology:Hagens Berman Sobol Shapiro: Lawsuit Filed Against CellCyte Genetics Corporation 2Hagens Berman Sobol Shapiro: Lawsuit Filed Against CellCyte Genetics Corporation 3Twenty-One Brinks Hofer Gilson & Lione Attorneys Named 2008 'Illinois Super Lawyers' 2Emmy(R)- and Golden Globe(R)-Nominated Actress Marcia Cross to Join Lifetime Networks and Members of Congress From Both Parties at Capitol Hill Press Conference 2Emmy(R)- and Golden Globe(R)-Nominated Actress Marcia Cross to Join Lifetime Networks and Members of Congress From Both Parties at Capitol Hill Press Conference 3
(Date:9/21/2014)... (SACRAMENTO, Calif.) Mothers of children with autism are significantly ... during their pregnancies than the mothers of children who ... UC Davis MIND Institute has found. , Low iron ... autism in the child if the mother was 35 ... or if she suffered from metabolic conditions such as ...
(Date:9/21/2014)... In recent years, new strains of bacteria have emerged ... these superbugs, including drug-resistant forms of tuberculosis and staphylococcus, ... at least 23,000. Despite the urgent need for new ... antibiotics in the past decade. , MIT engineers have ... Using a gene-editing system that can disable any target ...
(Date:9/19/2014)... Call it the Jimmy Durante of dinosaurs ... nasal profile. The new dinosaur, named Rhinorex ... University and Brigham Young University, lived in what ... during the Late Cretaceous period. , Rhinorex, which ... and a close relative of other Cretaceous hadrosaurs ...
Breaking Biology News(10 mins):Mothers of children with autism less likely to have taken iron supplements 2Battling superbugs 2Battling superbugs 3Battling superbugs 4New hadrosaur noses into spotlight 2
... to the evolutionary puzzle to explain why certain mammal families ... In research published in Proceedings of the Royal Society ... Dr Alistair Evans proposed a new theory explaining the diversity ... around two grams, to the blue whale which clocks in ...
... June 24, 2013 /PRNewswire-iReach/ -- Strax Rejuvenation, one of the ... just announced a "Get Ready for Summer" promotion that features ... (Photo: http://photos.prnewswire.com/prnh/20130624/CG36984 ) For ... syringe instead of the usual price of $550; and Radiesse ...
... from a rare metabolic complication during pregnancy are programmed to ... Journal of Clinical Investigation . The study is ... babies born to mothers with intrahepatic cholestasis of pregnancy (ICP), ... by the build-up of bile acids in the bloodstream. ...
Cached Biology News:From minute to massive -- mammal size evolution explained 2Non-Surgical Procedures are Now Available at a Discount at Strax Rejuvenation 2Non-Surgical Procedures are Now Available at a Discount at Strax Rejuvenation 3Rare pregnancy condition programs babies to become overweight in later life 2Rare pregnancy condition programs babies to become overweight in later life 3
BD Falcon 850 cm Smooth-surface TufRol Roller Bottle, tissue-culture treated polystyrene, blow-molded one-piece design, with easy on/off non-vented cap. (2/sp, 20/ca) Packaging: 2 / pack, 20 /...
... Protein Kit is a simple and convenient method ... The kit has been optimized for use with ... used for any fungus species that is susceptible ... procedure effectively generates spheroplasts of yeast cells that ...
... syringe pump series combines Harvard Apparatuss best pump ... a wide range of configuration options. A lookup ... of syringes from all the major manufacturers. A ... the pertinent information from across the lab. All ...
... PHD2000 syringe pump series combines Harvard Apparatuss best ... and a wide range of configuration options. A ... dimensions of syringes from all the major manufacturers. ... all the pertinent information from across the lab. ...
Biology Products: