Date:1/21/2011

components of the innate immune system to combat cancer, either as a monotherapy or in combination with current treatment regimens, without incremental toxicity. NewLink's lead product candidate, HyperAcute Pancreas cancer immunotherapy is being studied in a Phase 3 clinical trial in surgicallyresected pancreatic cancer patients.  This clinical trial is being performed under a Special Protocol Assessment with the U.S. Food and Drug Administration.  NewLink and its collaborators have completed patient enrollment for a Phase 1/2 clinical trial evaluating its HyperAcute Lung cancer immunotherapy product candidate for non-small cell lung cancer and a Phase 2 clinical trial for its HyperAcute Melanoma cancer immunotherapy product candidate.  NewLink is also developing d-1-methyltryptophan, or D-1MT, a smallmolecule, orally bioavailable product candidate from NewLink's proprietary indoleamine(2, 3)dioxygenase, or IDO, pathway inhibitor technology.  Through NewLink's collaboration with the National Cancer Institute, NewLink is studying D-1MT in various chemotherapy and immunotherapy combinations in two Phase 1B/2 safety and efficacy clinical trials.  For more information please visit us at www.linkp.com.

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