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NewLink Genetics to Present Phase 2 Data of Its HyperAcute® Pancreas Immunotherapy at ASCO 2011 Gastrointestinal Cancers Symposium
Date:1/21/2011

-GT, which is expressed in the cells of lower mammals but not present in human or other Old World primate cells. The presence of this enzyme results in the expression of a non-human form of carbohydrate called alpha (1,3) galactosyl carbohydrates, or α-Gal, on the surface of affected cells. Introducing α-Gal expressing cells to the human or primate immune system activates an immune response from antibodies against α-Gal. Antibodies directed against the α-Gal epitope are potentially the most abundant natural antibody in humans and represent approximately 1% of circulating human antibodies.

NewLink's HyperAcute cancer immunotherapy product candidates are composed of irradiated, live, allogeneic human cancer cells modified to express the gene that makes α-Gal epitopes. This exposure to α-Gal stimulates the human immune system to attack and destroy the immunotherapy cells on which α-Gal is present by activating complement, an important component of the immune system that is capable of cell destruction. After destruction, NewLink believes the resulting cellular fragments bound by anti-α-Gal antibodies are processed by the immune system to elicit an enhanced multifaceted immune response to tumorassociated antigens common to both the immunotherapy and the patient's tumor cells.

About HyperAcute Pancreas Immunotherapy

NewLink's HyperAcute Pancreas investigational product consists of equal doses of two separate allogeneic pancreatic cancer cell lines engineered to express α-Gal. Although cells making up naturally occurring pancreatic tumors in patients do not express α-Gal, the tumor cells share other molecules, called tumorspecific or tumorassociated antigens, with the genetically altered pancreatic cancer cells contained in HyperAcute Pancreas. NewLink believes the molecules that are common to a patient's tumor cells and HyperAcute Pancreas immunotherapy cells allow the antibodies and immu
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