Navigation Links
NewLink Genetics Initiates Phase 2 Trial of IDO Pathway Inhibitor, Indoximod, for the Treatment of Metastatic Breast Cancer
Date:4/2/2013

Recent studies have demonstrated that IDO is overexpressed in many cancers, within both tumor cells as a direct defense against T-cell attack, and also within antigen presenting cells in tumor draining lymph nodes whereby IDO promotes peripheral tolerance to tumor associated antigens (TAAs). When hijacked by developing cancers in this manner, IDO may facilitate the survival, growth, invasion, and metastasis of malignant cells expressing TAAs that might otherwise be recognized and attacked by the immune system. Indoximod is currently in multiple Phase 1B/2 studies targeting breast cancer. These include combination studies with docetaxel and with an autologous p-53 Dendritic Cell vaccine. In addition to its clinical product candidate indoximod, NewLink has an active program directed at synthesizing other IDO pathway inhibitors.

About NewLink Genetics Corporation

NewLink Genetics Corporation is a biopharmaceutical company focused on discovering, developing and commercializing novel immunotherapeutic products to improve treatment options for cancer patients. NewLink's portfolio includes biologic and small-molecule immunotherapy product candidates intended to treat a wide range of oncology indications. NewLink's product candidates are designed to harness multiple components of the immune system to combat cancer without significant incremental toxicity, either as a monotherapy or in combination with other treatment regimens. NewLink's lead product candidate, algenpantucel-L (HyperAcute® Pancreas) is being studied in a Phase 3 clinical trial in surgically resected pancreatic cancer patients (under a Special Protocol Assessment with the U.S. FDA) as well as in a separate study in locally advanced pancreatic cancer patients. NewLink has recently launched an adaptive design Phase 2B/3 clinical trial of tergenpumatucel-L (HyperAcute® Lung) in patients with non-small cell lung cancer. NewLink is developing indoximod, a small-molecule, orally bioav
'/>"/>

SOURCE NewLink Genetics Corporation
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. Epigenetics: Changing the Way We Think about DNA
2. Research and Markets: Cytogenetics - Technologies, Markets and Companies - 2013
3. Plunketts Biotech & Genetics Industry Almanac 2013: Biotech & Genetics Industry Market Research, Statistics, Trends & Leading Companies
4. Plunketts Biotech & Genetics Industry Trends & Statistics 2013: A Summary Version of Plunketts Biotech & Genetics Industry Almanac 2013
5. GeneTex Launches New Antibody Against Phosphorylated Histone H3 for Epigenetics Research
6. The American College of Obstetricians and Gynecologists Committee on Genetics and the Society for Maternal-Fetal Medicine Publications Committee Recommend Noninvasive Prenatal Testing for Fetal Aneuploidy
7. Response Genetics, Inc. to Offer ROS1 Testing for Lung Cancer
8. Epigenetics Holds Key to Healthier Future
9. Response Genetics, Inc. Announces Second Quarter Financial Results
10. Genetics Policy Institute (GPI) Collaborates on Second Midwest Conference on Stem Cell Biology and Therapy, Oct. 5-7 at Oakland University
11. Applied Genetics Initiates Commercial Operation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... 30, 2014  Replikins Ltd. today released new data ... virus. Before the current outbreaks, the mean Ebola Reston ... acids) between 1995 and 2002 was 1.1; the mean ... and sixteen-fold in 2013, thus predicting the current outbreaks ... has been shown to be able to predict outbreaks ...
(Date:7/30/2014)... , July 30, 2014   Wyle ... Fully Integrated Lifecycle Mission Support Services (FILMSS) contract ... (NASA). Under the terms of the contract, Wyle ... at Moffett Field, Calif. In particular, Wyle will ... flight development projects on the International Space Station ...
(Date:7/30/2014)... Vycom announces the addition of Thermax PVC ... Factory Mutual (FM) 4910 fire propagation and smoke generation ... process tools, fume hoods, furniture and cabinetry. These criteria ... wafers used in electronic chip manufacturing. , ... excellent workability and superior aesthetics. It is available in ...
(Date:7/30/2014)... July 30, 2014 Researchers often use ... biology, but such devices can do much more ... As such, researchers have looked to patterned assemblies ... metabolic engineering to characterize – and potentially ... devices are envisioned to recreate animal and human ...
Breaking Biology Technology:Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2Vycom Announces Flametec® Thermax PVC (FM4910 Listed) For a Variety of Clean Room Applications with Excellent Workability and Aesthetics 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 3UMD Researchers Bridge Gap between Microelectronics, Biological Systems 4
... , , SAN MARINO, ... VRAL) has formed a wholly owned subsidiary called MetaCytoLytics, Inc. ... University of Colorado Professor M. Karen Newell called "metabolic disruption ... to generate energy from glucose or from fatty acids. ...
... , , EMERYVILLE, Calif., ... announced that it has agreed to sell an aggregate of four million ... $30.50 per share and $200 million aggregate principal amount of its 4.00% ... has granted the underwriters 30-day options to purchase up to an additional ...
... rate significantly reduced and Semen Sexing Technology achieves, ... For nine months ended June 30, 2009, Microbix Biosystems Inc. ... The third quarter had a small sales retraction that was ... forecast is for continued growth in sales. , "The 22% ...
Cached Biology Technology:Viral Genetics Creates Subsidiary to Develop Cancer Therapy 2Viral Genetics Creates Subsidiary to Develop Cancer Therapy 3Viral Genetics Creates Subsidiary to Develop Cancer Therapy 4Onyx Pharmaceuticals Announces Pricing of Concurrent Offerings of Four Million Shares of Common Stock and $200 Million Principal Amount of Convertible Senior Notes 2Onyx Pharmaceuticals Announces Pricing of Concurrent Offerings of Four Million Shares of Common Stock and $200 Million Principal Amount of Convertible Senior Notes 3Microbix Sales Grow 22% For Nine Months 2Microbix Sales Grow 22% For Nine Months 3Microbix Sales Grow 22% For Nine Months 4Microbix Sales Grow 22% For Nine Months 5
(Date:7/30/2014)... online today in the journal Scientific Reports , ... and Auroop Ganguly found that while global temperature is ... extremes. For instance, while each year,s average hottest and ... tend to fall within a wider range of potential ... observed. This means that even as overall temperatures rise, ...
(Date:7/29/2014)... methods and applications for imaging and manipulation of the ... were the inspiration behind Neurophotonics , a new ... optics and photonics. , The first issue coincides with ... States, and a special section features articles that lay ... impact that optics and photonics will have on advancing ...
(Date:7/29/2014)... sometimes need to get back to basics. UC ... study the impacts of the bumphead parrotfish ( ... two remote locations in the central Pacific Ocean. ... simulation, McCauley, an assistant professor in the Department ... colleagues sought to understand whether the world,s largest ...
Breaking Biology News(10 mins):Big data confirms climate extremes are here to stay 2SPIE launches Neurophotonics journal with special section on BRAIN Initiative 2SPIE launches Neurophotonics journal with special section on BRAIN Initiative 3Underwater elephants 2Underwater elephants 3
... N.Y. To make paper, manufacturers must break down ... requires large amounts of energy and toxic chemicals like ... biodegradable proteins that accelerate chemical reactions using far less ... the job, in this case xylanases, don,t hold up ...
... the National Institute of Standards and Technology (NIST) and ... a simplified cell membrane to accurately detect and measure ... vaginosis (BV), at extraordinarily low concentrations. The work illustrates ... disease diagnosis. Caused by the bacteria Gardnerella ...
... release is available in German . ... of thousands of neurons in the brain. Nerve growth factors produced ... neurons; however, clinical tests with GDNF have not yielded in any ... Martinsried and their colleagues have now succeeded in demonstrating that GDNF ...
Cached Biology News:Expanding the range of nature's catalysts for industrial applications 2Expanding the range of nature's catalysts for industrial applications 3NIST cell membrane model studied as future diagnostic tool 2Parkinson gene: Nerve growth factor halts mitochondrial degeneration 2Parkinson gene: Nerve growth factor halts mitochondrial degeneration 3
Functionally tested for consistent G-banding of chromosomes....
... BacVector Insect Cell Medium is optimized ... Ea4 Insect Cells. In this protein-free medium, ... 1 * 107 cells/ml with viabilities above ... plaque assays, where color from X-gluc staining ...
... Grace's Insect Medium is formuatled for ... including Sf9 and Sf21 cells. Grace's ... transfectioin because it does not contain ... interfere with transfection. Grace's Insect Medium, ...
TNM-FH Insect Medium 1 liter...
Biology Products: