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New yeast trick for eating favorite food: Details in Nature paper
Date:7/30/2008

sty, who stressed the utility of their tried-and-true engineering approach. "We drove our system with a sine wave in typical engineering fashion, and sure enough, we learned something interesting."

The undulating sine wave represents pulses of glucose delivered to the yeast cells while galactose levels remained constant.

When the glucose pulses started coming faster and faster, the model underestimates the ability of the yeast to react to the glucose pulse by shutting down the galactose metabolic network.

This discrepancy between the experimental results and the model predictions got the bioengineers thinking about what could be happening that is not captured in the current model. A combination of computational modeling and experimental work led the researchers to a new post-transcriptional control mechanism in which jumps in glucose increase the degradation rate of messenger RNA that are crucial for the functioning of the galactose metabolic network.


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Contact: Daniel Kane
dbkane@ucsd.edu
858-534-3262
University of California - San Diego
Source:Eurekalert  

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