Navigation Links
New technology delivers sustained release of drugs for up to 6 months
Date:8/13/2012

A new technology which delivers sustained release of therapeutics for up to six months could be used in conditions which require routine injections, including diabetes, certain forms of cancer and potentially HIV/AIDS.

Researchers from the University of Cambridge have developed injectable, reformable and spreadable hydrogels which can be loaded with proteins or other therapeutics. The hydrogels contain up to 99.7% water by weight, with the remainder primarily made up of cellulose polymers held together with cucurbiturils - barrel-shaped molecules which act as miniature 'handcuffs'.

"The hydrogels protect the proteins so that they remain bio-active for long periods, and allow the proteins to remain in their native state," says Dr Oren Scherman of the Department of Chemistry, who led the research. "Importantly, all the components can be incorporated at room temperature, which is key when dealing with proteins which denature when exposed to high heat."

The hydrogels developed by Scherman, Dr Xian Jun Loh and PhD student Eric Appel are capable of delivering sustained release of the proteins they contain for up to six months, compared with the current maximum of three months. The rate of release can be controlled according to the ratio of materials in the hydrogel.

Not only do these hydrogels double the window of content release, they use far less non-water material than current technology. The extra material serves as a type of scaffolding holding the hydrogel together, but it can affect performance of the cargo contained within it, so the less structure-forming material contained within the hydrogel, the more effectively it will perform.

As drug therapy moves away from small molecule drugs toward protein-based therapy, applications such hormone therapy, wound healing and insulin treatment would all be ideal applications for the hydrogels.

For example, more than a quarter of the 2.9 million individuals in the UK who
'/>"/>

Contact: Sarah Collins
sarah.collins@enterprise.cam.ac.uk
44-122-376-0335
Cambridge Enteprise University of Cambridge
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Astrix Technology Group Awarded Department of Homeland Security BioWatch Laboratory Staffing Contract
2. Global Marine Biotechnology Industry
3. Frost & Sullivan Recognizes MicroProtein Technologies for its Path-Breaking Production Technology for Recombinant Proteins in Bacteria
4. First Plant Genomics Yield Technology Progresses
5. RIT professor receives National Science Foundation grant to improve on-chip networks with wireless technology
6. Verenium Corporation And Alexandria Real Estate Equities, Inc. Celebrate The Grand Opening Of A New State-of-the-art Biotechnology Facility
7. Afraxis and PsychoGenics Form Alliance to Offer Afraxis ESP Technology for Drug Discovery
8. Shape-shifting materials are goal of new nanotechnology project
9. Oramed Pharmaceuticals Granted 2nd Patent in New Zealand; 3rd Patent for Core Technology on Oral Delivery of Proteins
10. Life Technologies to Accelerate Development of Ion Torrent Semiconductor Technology for Proteomic Applications in Research, Applied and Clinical Markets
11. New silk technology preserves heat-sensitive drugs for months without refrigeration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 10, 2014 Product and process ... low abundance and are often “lost in the ... , Join presenters Dr. Rowel Tobias, Senior Scientist, ... Anders, Head of Quality at Nanotherapeutics, Inc., to ... can speed detection and quantitation while achieving the ...
(Date:7/10/2014)... Unraveling life’s mysteries can intrigue, amaze, and ... purchased a DNA test to unravel the ... a lifetime of memories, sharing, and closeness. In fact, ... genuinely brought the family closer together. , Recently, ... history and prior to taking the genetic ancestry ...
(Date:7/10/2014)... July 10, 2014 Senior supply chain ... professional associations, addressed the challenges of “Reducing Cost, Lead ... Industries” through strategic sourcing. Describing the partnership of the ... Supply Chain Management Institute ( SCMI) of the ... June 24 at the Kroc Institute of Peace and ...
(Date:7/10/2014)... PROVO, Utah , July 10, 2014 ... genome annotation and interpretation, today announced an ... sequencing (NGS) analytics for Lineagen,s NextStep Dx ... evaluation of neurodevelopmental and neurological disorders, currently ... chromosomal microarray (CMA) testing service used by ...
Breaking Biology Technology:Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4
... the growing open source clincial trials software. This release contains ... regulated industry sponsored clinical trials. , ... ... announces the availability of OpenClinica 2.5, the popular open source ...
... Mass., Sept. 19 Boston Scientific,Corporation (NYSE: BSX ... Life,Sciences Conference, which is being held September 22 - ... Chief Executive Officer, will make a,30-minute presentation which will ... Thursday, September 25, beginning at approximately 9:00,a.m. ET., ...
... Sept. 19 Abbott (NYSE:,ABT) will announce its 2008 ... market opens., The announcement will be followed by ... a.m. Central time (9 a.m. Eastern), and will be,accessible ... An archived edition of the call will be,available after ...
Cached Biology Technology:Akaza Research Releases New Version of OpenClinica Electronic Data Capture (EDC) Software; Targets Industry Clinical Trials 2Akaza Research Releases New Version of OpenClinica Electronic Data Capture (EDC) Software; Targets Industry Clinical Trials 3
(Date:7/10/2014)... July 1, 2014 Smart technology emphasis ... convenience and improved security: NXT-ID, Inc. (OTCBB: NXTD), eBay Inc. ... GOOG ), Apple Inc. (NASDAQ: AAPL ), Visa ... MA) NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company ... that the second series of 30 second spots on CNBC ...
(Date:7/10/2014)... Conn. , July 2, 2014 NXT-ID, Inc., (OTCQB: ... reports that CEO Mr. Gino Pereira was interviewed ... show in Tampa Florida . Mr. Pereira ... host Cedric Harris and how the Wocket™ aims ... alternative.  Cedric Harris tells Gino ...
(Date:7/10/2014)... , July 7, 2014 Fingerprint Cards, ... major design win (DW). A Chinese Top 5 smartphone OEM ... start of mass production in October 2014.   ... Top 5 smartphone OEM, which has a planned date for ... target sales volume for this phone of 3 million units. ...
Breaking Biology News(10 mins):Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW for 1021 Touch Sensor for Flagship Smartphone from Chinese Top 5 Smartphone OEM 2
... can be converted to electricity, potentially providing power for sensors, ... researchers at Case Western Reserve University report. The finding ... the country that could bring the creation of insect cyborgs ... out of science fiction and into reality. In this case, ...
... In the two and a half years since Adam Bogdanove, ... Pathology and Microbiology, along with Matthew Moscou, a former graduate ... from plant pathogenic bacteria find and bind specific sequences in ... discovery. Last year it was first shown that the ...
... cost-effective, a group of researchers from National Tsing Hua University ... have created a DNA-based memory device that is "write-once-read-many-times" (WORM), ... to encode information. The device, described in a paper accepted ... a thin film of salmon DNA that has been embedded ...
Cached Biology News:Implanted biofuel cell converts bug's chemistry into electricity 2Implanted biofuel cell converts bug's chemistry into electricity 3ISU scientist helps find structure of gene-editing protein named Method of the Year 2
Kit for BASE20/50 dual control unit, includes mounting plate, HOLDER50T, HEATERPAD50, SRTDX temperature probe(s)....
... 10 nM is available for in ... described in: Z. Hassani, G.-F. Lemkine, P. ... and B.-A. Demeneix. Lipid-mediated siRNA delivery down ... brain at picomolar levels. J. Gene Med., ...
... The IHC Select Immunoperoxidase Secondary Detection ... rat or goat IgG in the Primary ... antigens present in the specimen. Any excess ... Secondary Antibody Reagent (conjugated to biotin) is ...
... Cellular uptake of long double stranded RNA ... interference in a diverse group of organisms ... RNA interference leads to the inhibition of ... of the target messenger RNA (mRNA). Attempts ...
Biology Products: