Navigation Links
New technology delivers sustained release of drugs for up to 6 months
Date:8/13/2012

A new technology which delivers sustained release of therapeutics for up to six months could be used in conditions which require routine injections, including diabetes, certain forms of cancer and potentially HIV/AIDS.

Researchers from the University of Cambridge have developed injectable, reformable and spreadable hydrogels which can be loaded with proteins or other therapeutics. The hydrogels contain up to 99.7% water by weight, with the remainder primarily made up of cellulose polymers held together with cucurbiturils - barrel-shaped molecules which act as miniature 'handcuffs'.

"The hydrogels protect the proteins so that they remain bio-active for long periods, and allow the proteins to remain in their native state," says Dr Oren Scherman of the Department of Chemistry, who led the research. "Importantly, all the components can be incorporated at room temperature, which is key when dealing with proteins which denature when exposed to high heat."

The hydrogels developed by Scherman, Dr Xian Jun Loh and PhD student Eric Appel are capable of delivering sustained release of the proteins they contain for up to six months, compared with the current maximum of three months. The rate of release can be controlled according to the ratio of materials in the hydrogel.

Not only do these hydrogels double the window of content release, they use far less non-water material than current technology. The extra material serves as a type of scaffolding holding the hydrogel together, but it can affect performance of the cargo contained within it, so the less structure-forming material contained within the hydrogel, the more effectively it will perform.

As drug therapy moves away from small molecule drugs toward protein-based therapy, applications such hormone therapy, wound healing and insulin treatment would all be ideal applications for the hydrogels.

For example, more than a quarter of the 2.9 million individuals in the UK who have diabetes have to inject themselves daily with insulin in order to control blood glucose levels. Containing the insulin within a hydrogel could potentially reduce the number of annual injections from 365 to just two.

The long-term sustained release would be especially useful in resource-deprived or rural settings where patients requiring daily medication may not have regular access to a doctor. "There's been a lot of research that shows patients who need to take a pill each day for the rest of their lives, especially HIV patients in Africa who do not show any obvious symptoms, will take the pills for a maximum of six months before they stop, negating the point of taking the medication in the first place," says Appel. "If patients only have to take one shot which will give them six month's worth of medication, we'll have a much greater chance of affecting an entire population and slowing or stopping the progression of a disease."

The team are currently working with researchers from the Brain Repair Centre in the Department of Clinical Medicine on how the technology might be used as a possible treatment for brain cancer.

The research was published recently in the journal Biomaterials and has been patented by Cambridge Enterprise, the University's commercialisation group.


'/>"/>

Contact: Sarah Collins
sarah.collins@enterprise.cam.ac.uk
44-122-376-0335
Cambridge Enteprise University of Cambridge
Source:Eurekalert

Related biology technology :

1. Astrix Technology Group Awarded Department of Homeland Security BioWatch Laboratory Staffing Contract
2. Global Marine Biotechnology Industry
3. Frost & Sullivan Recognizes MicroProtein Technologies for its Path-Breaking Production Technology for Recombinant Proteins in Bacteria
4. First Plant Genomics Yield Technology Progresses
5. RIT professor receives National Science Foundation grant to improve on-chip networks with wireless technology
6. Verenium Corporation And Alexandria Real Estate Equities, Inc. Celebrate The Grand Opening Of A New State-of-the-art Biotechnology Facility
7. Afraxis and PsychoGenics Form Alliance to Offer Afraxis ESP Technology for Drug Discovery
8. Shape-shifting materials are goal of new nanotechnology project
9. Oramed Pharmaceuticals Granted 2nd Patent in New Zealand; 3rd Patent for Core Technology on Oral Delivery of Proteins
10. Life Technologies to Accelerate Development of Ion Torrent Semiconductor Technology for Proteomic Applications in Research, Applied and Clinical Markets
11. New silk technology preserves heat-sensitive drugs for months without refrigeration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... ... 2016 , ... Mosio, a leader in clinical research patient ... and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits the hurdle ... and strategies for clinical researchers. , “The landscape of how patients receive and ...
(Date:6/23/2016)... , June 23, 2016 A person commits ... the crime scene to track the criminal down. ... U.S. Food and Drug Administration (FDA) uses DNA evidence to ... Sound far-fetched? It,s not. The FDA has ... to support investigations of foodborne illnesses. Put as simply as ...
(Date:6/23/2016)... 2016  The Biodesign Challenge (BDC), a university competition ... harness living systems and biotechnology, announced its winning teams ... New York City . The ... projects at MoMA,s Celeste Bartos Theater during the daylong ... senior curator of architecture and design, and Suzanne ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... In a ... Hospital in Denmark detail how a patient who developed lymphedema after being treated for ... The results could change the paradigm for dealing with this debilitating, frequent side effect ...
Breaking Biology Technology:
(Date:4/26/2016)... April 27, 2016 Research ... Multi-modal Biometrics Market 2016-2020"  report to their offering.  ... The analysts forecast the global multimodal ... 15.49% during the period 2016-2020.  Multimodal ... sectors such as the healthcare, BFSI, transportation, automotive, ...
(Date:4/14/2016)... 14, 2016 BioCatch ™, ... today announced the appointment of Eyal Goldwerger ... Goldwerger,s leadership appointment comes at a time ... the deployment of its platform at several of the ... which discerns unique cognitive and physiological factors, is a ...
(Date:3/29/2016)... BOCA RATON, Florida , March 29, 2016 /PRNewswire/ ... ("LegacyXChange" or the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect ... Synthetic DNA in ink used in a variety of ... preventing theft. Buyers of originally created collectibles from athletes ... authenticity through forensic analysis of the DNA. ...
Breaking Biology News(10 mins):