Navigation Links
New technology could inspire brain implant for detecting and treating seizures
Date:6/1/2011

Tiny electrodes have been coated with a drug-loaded polymer in an attempt to design an implant capable of detecting a number of neurological symptoms, such as those associated with an epileptic seizure, and treating them simultaneously.

In a study published today, 2 June 2011, in IOP Publishing's Journal of Neural Engineering, researchers have developed a novel technology to precisely modulate individual neurons in rats, allowing the molecular, neuronal, and circuit functions to be analysed with unprecedented precision.

Based on the electrical conducting properties of the polymer Polypyrrole (PPy), the researchers, from the University of Pittsburgh, have demonstrated a novel way of loading specific drugs onto an array of electrodes and triggering their release into cultured neurons, allowing for a more precise insight into the cellular mechanisms of neuronal networks.

On top of this, the researchers have also demonstrated how the release of drugs could be informed, in real-time, by the recording of activity in neurons, a step essential for creating a closed-loop system that both diagnoses and treats symptoms simultaneously, creating several potential applications.

Co-author Professor X Tracy Cui said, "We envision an implanted device in the future that will monitor the brain activity, detect or predict an onset of epileptic seizure, and send the command to the electrode at the most appropriate location, releasing an anti-convulsive drug to prevent the seizure."

Multielectrode arrays (MEAs) small devices that can control or record the electrical circuitry in neurons have long been used as a way of measuring neuronal activity and transforming this into an action; technologies such as ear implants and cardiac pacemakers have benefited from them.

Recent advances, however, have allowed MEAs to be coupled with devices that release specific drugs in order to test how neural circuits function, as well as investigating the underlying mechanisms within neuronal cells.

The researchers coated PPy, containing all of the necessary neurochemicals, onto an MEA. Whilst positioned on the cultured rat brain, the polymer was electrically stimulated, causing the neurochemicals to dissociate and diffuse away to the necessary locations.

Results showed that the drugs retained their activity and function with spatial and temporal precision.

Current state-of-the-art drug delivery methods, such as picospritzer and ionotopheriesis, give researchers a greater understanding of cellular mechanisms of neural dynamics; however, both of these techniques are limited to a few sites and face the risk of drug leakage.

By having the required neurochemicals dissociate from the polymer, this technique avoids the need for an external reservoir containing the drug, which would greatly increase the size of a potential implant and could cause tissue damage.

Professor Cui continues, "By directly loading a drug of interest onto an individual electrode site and using an electrical signal to trigger its release, we can precisely control the drug delivery site with ease. Additionally, our technology can be used for a combination of exogenous chemicals such as subtype-specific receptor antagonists, thus potentially allowing for more precise dissection of neural circuit function at the molecular level."


'/>"/>

Contact: Michael Bishop
michael.bishop@iop.org
44-117-930-1032
Institute of Physics
Source:Eurekalert

Related biology technology :

1. InNexus Biotechnology Announces Launch of Large Scale Primate Study of DXL625
2. CardioWest™ Artificial Heart Approved For Highest Reimbursement in CMS History : Plus Up To $53,000 New Technology Add-on Payments
3. Yongye Biotechnology International Retains CCG Investor Relations
4. William F. Prendergast Named One of the Top IP Lawyers in Nanotechnology
5. John Grisham Joins Focused Ultrasound Surgery Foundation Board, Citing Novel Technologys Potential to Help Millions of Patients
6. Yongye Biotechnology International Announces Conference Call to Discuss Second Quarter 2008 Results
7. [video] Jacques Tizabi, CEO of Universal Detection Technology Discusses Latest Purchase Order on WallSt.nets 3-Minute Press Show
8. Yongye Biotechnology International Announces Second Quarter Results
9. BeaconEquity.com Issues Trade Alerts on Biotechnology Stocks: ELN, PFE, AMGN, DNA, BIIB, GILD
10. ArunA Biomedical Announces Exclusive Worldwide Technology Licensing Agreement to Commercialize Human Embryonic Stem Cell Derived Mesenchymal Cells
11. Lixte Biotechnology Holdings Announces Filing of a New Patent Application for Cancer Therapy Based on Targeting a Biomarker by Novel Investigational Agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... ... 23, 2016 , ... Supplyframe, the Industry Network for electronics ... Lab . Located in Pasadena, Calif., the Design Lab’s mission is to bring ... designed, built and brought to market. , The Design Lab is Supplyframe’s physical ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published today ... a patient who developed lymphedema after being treated for breast cancer benefitted from an ... paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... 2016 On Wednesday, June 22, 2016, ... 0.22%; the Dow Jones Industrial Average edged 0.27% lower to ... down 0.17%. Stock-Callers.com has initiated coverage on the following equities: ... (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing their ...
Breaking Biology Technology:
(Date:6/9/2016)... , June 9, 2016 ... deploy Teleste,s video security solution to ensure the safety of ... during the major tournament Teleste, an ... systems and services, announced today that its video security solution ... to back up public safety across the country. The ...
(Date:6/2/2016)... YORK , June 2, 2016   The Weather ... is announcing Watson Ads, an industry-first capability in which consumers ... by being able to ask questions via voice or text ... Marketers have long sought ... the consumer, that can be personal, relevant and valuable; and ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is ... partnership with VoicePass. By working together, ... experience.  Because VoiceIt and VoicePass take slightly different ... engines increases both security and usability. ... excitement about this new partnership. "This ...
Breaking Biology News(10 mins):