Navigation Links
New target for anti-flu drug development
Date:9/22/2007

Boston, August 15, 2007---Scientists at Cure Lab, Inc., a biotechnology company based in Canton, Massachusetts, in collaboration with researchers at Boston University and Harvard Medical School have discovered a potential new target for the development of anti-influenza (flu) drugs, including those that may be effective against potentially pandemic influenza strains like H5N1.

Their findings have been published in the August 15, 2007 issue of the journal Cell Cycle.

The potential drug target is the flu protein M2, long known to be highly conserved between avian and human strains of the virus. Scientists at Cure Lab found that this M2 protein may single-handedly kill human cells.

This effect may constitute a previously unknown mechanism of influenza virus pathogenicity said Dr. Alex Shneider, senior author on the paper and CEO of the company. If so, drugs that are shown to prevent M2-dependent cell killing have the potential to be used for the treatment of flu.

Membranes covering human and avian cells do not allow ions to move in and out of the cell freely, thus maintaining internal homeostasis. M2 protein of flu virus forms ion channels allowing ion trafficking into cells that cells no longer control. Dr. Shneider and his group not only demonstrated that M2 kills mammalian cells, but also showed that ion channeling through M2 pores may be a molecular mechanism of this cell killing process. Dr. Shneider said that Developing drugs which block M2 ion channels could reduce or eliminate M2-induced cell death, and thus may be a new strategy for targeted development of anti-influenza drugs.

In collaboration with Dr. Vladimir L. Gabai from Boston University, and Dr. Shamil R. Sunyaev from Harvard Medical School scientist from Cure Lab, Inc. have developed mutant forms of M2 protein, where the ion channel is blocked. The researchers have shown that these specific mutations they introduced in the protein significantly reduc
'/>"/>

Contact: Alex Shneider
thoidis@curelab.com
609-841-1201
Cure Lab, Inc.
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Enhanced Amplification of Long Targets with PfuTurbo DNA Polymerase
2. Microarray Target Purification Kit and the Microarray Target Synthesis Kit (T7)
3. Gene Expression Arrays: Highly Sensitive Detection of Expression Patterns with Improved Tools for Target Amplification
4. Detection of antibody-stained cell surface and intracellular protein targets with the Agilent 2100 bioanalyzer
5. Protect RNA and Improve Target Cell Identification
6. Feasibility of Multiplexing Bio-Plex Total Target and Phosphoprotein Assays
7. Development of Radioligand Binding Assays for the Motilin Receptor Using ScreenReady Targets.
8. Calcium Plus Assay Kit, Superior Detection for Specialized Targets
9. ESR1 Gene Expression in Oncology and Metabolic Diseases Using the ASCENTATM System Target Validation and Identification of Novel Disease Indications
10. A Screen of shRNAs Targeting Tumor Suppressor Genes to Identify Factors Involved in Paclitaxel Sensitivity
11. TomoTherapy revises IPO money target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... The 6th Annual Arrowhead Personalized ... October 29-30 in San Francisco, CA. This year’s conference ... researchers and clinicians focused on addressing and solving the ... the twelve years since the sequencing of the human ... with pharmacogenetic information in the label and molecular diagnostics ...
(Date:8/20/2014)... could improve the health of your heart, researchers have ... used a standard TENS machine like those designed to ... tragus, the small raised flap at the front of ... , The stimulation changed the influence of the nervous ... that can drive failing hearts too hard. , Professor ...
(Date:8/19/2014)... NJ (PRWEB) August 20, 2014 ... and regenerative medicine is an inadequate vascular supply. ... constructs and decellularized tissues is critical for successful ... have attempted to mitigate deficiencies in vascularization and ... adding scaffold bioactivity, optimizing scaffold design and architecture, ...
(Date:8/19/2014)... -- A Geisinger researcher on a personal crusade against ... Disease Control and Prevention (CDC) award recognizing his unprecedented ... Joseph Boscarino , Ph.D. MPH, senior scientist, ... researchers nominated for the Centers for Disease Control and ... Methods and Study Design. "Hepatitis C killed ...
Breaking Biology Technology:6th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2'Tickling' your ear could be good for your heart 2Vascularization in Tissue Engineering Highlighted at 12th New Jersey Symposium on Biomaterials Science 2Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3
... China, April 24 /Xinhua-PRNewswire-FirstCall/ -- China Sky One,Medical, ... (OTC Bulletin,Board: CSKI), a pharmaceutical company for external ... ("PRC"), today announced it,acquired Heilongjiang Haina Pharmaceutical Inc. ... laws of the PRC on April,18, 2008., ...
... announced today that Chairman and CEO Fred Hassan purchased,just ... 000 shares at,an average purchase price of $18.26 per ... intention to purchase these shares in,January, this investment in ... -- including ZETIA and VYTORIN --,and our late- stage ...
... 24 /PRNewswire/ - Aegera Therapeutics Inc. is very,pleased ... and,financial executives to its Board of Directors: Mr. ... Managers Limited, and Mr. Gary,Littlejohn, Managing Director of ... experience and networks will be,critical for Aegera as ...
Cached Biology Technology:China Sky One Medical, Inc. Acquires Heilongjiang Haina Pharmaceutical Inc. 2China Sky One Medical, Inc. Acquires Heilongjiang Haina Pharmaceutical Inc. 3Aegera Therapeutics welcomes two experienced executives to its board of directors 2
(Date:8/20/2014)... Area Lyme Foundation, which aims to make Lyme disease ... research published in an upcoming issue of the Elsevier ... The findings show that ticks that carry Lyme ... making the threat of Lyme disease year-round. The research ... Health (CDPH) Vector-borne Disease Section and University of California, ...
(Date:8/20/2014)... causes a burning spiciness that is irresistible to some, ... effect are using their findings to develop a new ... be caused by inflammation or other problems. They reported ... in clinical trials, in ACS, Journal of Medicinal ... decades ago, scientists had pegged a compound called capsaicin ...
(Date:8/20/2014)... of honeybees grows to about 4,000 members, it triggers ... building of a special type of comb used for ... from the Department of Neurobiology and Behaviour at Cornell ... reproductive cycle of honeybee colonies. The results are published ... Nature . , Reproduction isn,t always a honeybee ...
Breaking Biology News(10 mins):Lyme disease risk is year-round in Northwest California, according to new study 2Lyme disease risk is year-round in Northwest California, according to new study 3Worker bees 'know' when to invest in their reproductive future 2
... and hunger could be large over the next 20 years, ... higher temperatures could significantly reduce yields of wheat, rice and ... people who subsist on less than $1 a day. The ... and drive many into poverty. But even as some ...
... The old balkanized approach to ocean management, in ... laws and administered by different agencies, has failed to ... a panel of international scientists says, and should be ... planning. The panel, organized by scientists from Duke ...
... biologists and ecologists propose ever-larger conservation areas in the ... it,s local people banding together with their community leaders ... efforts in many parts of the world., "When people ... sacrifice," says Patrick Christie, University of Washington associate professor ...
Cached Biology News:Global warming may hurt some poor populations, benefit others 2Global warming may hurt some poor populations, benefit others 3Global warming may hurt some poor populations, benefit others 4Marine spatial planning: A more balanced approach to ocean management 2Marine spatial planning: A more balanced approach to ocean management 3Marine spatial planning: A more balanced approach to ocean management 4Local social dynamics key to success of tropical marine conservation areas 2
... The kit contains 5 ml CELLection Dynabeads ... against the human epithelial antigen EpCAM and ... 5 log enrichment of epithelial tumour cells ... Tumour cells clumps can be enriched from ...
Recombinant Human CCL21/6Ckine (Mucin Stalk Chimera)...
Recombinant Human Erythropoietin (Tissue Culture Grade)...
Acrylamide PAGE 40% Solution, 1 l. Category: Electrophoresis Systems & Standards & Reagents, Electrophoresis Standards and Reagents, Gel Casting Chemicals....
Biology Products: