Navigation Links
New study indicates smallpox vaccination effective for decades
Date:3/20/2009

New York, December 1, 2008 Although naturally occurring smallpox was eradicated in 1977, there is concern that bioterrorists might obtain smallpox from a laboratory and release it into the population. Under such circumstances, the supply of smallpox vaccine may be insufficient for universal administration. In a study published in the December 2008 issue of The American Journal of Medicine, researchers found that lifetime protection is obtained from just one vaccination, even when that vaccination occurred as much as 88 years ago. They conclude that in the event of a smallpox bioterrorist attack, vaccinia smallpox vaccine should be used first on individuals who have not been vaccinated previously.

Examining 246 participants of the Baltimore Longitudinal Study of Aging, investigators from the National Institute on Aging and the National Institute of Allergy and Infectious Diseases, National Institutes of Health found permanent immunity was conferred by vaccination or by survival from an active smallpox infection. In the sample, 209 subjects were vaccinated one or more times 13 to 88 years prior to the study; an additional 18 had had childhood smallpox, and 29 with no history of vaccination or smallpox were included.

Although the vaccinia virus vaccine was used since the late 18th century, routine vaccination was discontinued more than 30 years ago in many countries. Most Americans under 35 have never been vaccinated and most over 35 have not received booster immunizations since the early 1970s. If a bioterrorist attack were to occur, it would be critical to know who already had effective immunity and would not need to be vaccinated, leaving another dose available for someone else.

Current recommendations relating to smallpox vaccination has been that people with repeated exposure to smallpox, for example travelers to endemic areas, should be revaccinated every five years. This study suggests that such reimmunizations may not be necessary because multiple vaccinations achieve only marginally higher levels of antibody and virus neutralizing activity than single vaccination.

Writing in the article, Dan L. Longo, MD, National Institute on Aging, states "A major question posed today is whether those individuals vaccinated 40 or more years ago would be protected in the event of smallpox exposure. This may be a critical question because the availability of smallpox vaccines is limited and currently inadequate for a mass inoculation program. We found that vaccinated subjects maintain what appear to be protective levels of neutralizing antibodies to vaccinia indefinitely and do not require booster vaccinations even if they are many decades removed from primary vaccination. These data imply that limited supplies of vaccine can be more usefully applied to individuals who have never been vaccinated, primarily individuals born after 1972."


'/>"/>

Contact: Pamela Poppalardo
ajmmedia@elsevier.com
212-633-3944
Elsevier Health Sciences
Source:Eurekalert

Related biology technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
3. Kline Study: Better Brushing Habits Boost European Oral Care Sales
4. Evotec to Present Details of the Positive Phase II Study in Insomnia With EVT 201 at the Worldsleep07 Congress in Cairns/Australia
5. NASA study will help stop stowaways to Mars
6. New Study Findings Confirm CLEXANE(R)/LOVENOX(R) Long-Term Clinical Benefit in Patients Suffering From Acute Coronary Syndrome
7. Study Published in Clinical Cancer Research Confirms Potential Of Peregrines Bavituximab Combined With Radiation In Lung Cancer
8. Evotec Reports Details of the Positive Proof-of-Concept Phase II Study in Insomnia With EVT 201
9. Study Supports Use of GlycoMark Blood Test to Evaluate Therapy in Children with Diabetes
10. Quigley Corporation Releases Update on Quigley Pharmas Phase IIb Clinical Study of QR-333 in Diabetic Peripheral Neuropathy
11. Biodel Inc. Announces VIAject(TM) Phase II Meal Study Data at the 2007 European Association for the Study of Diabetes Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2017)... ... June 22, 2017 , ... Ovation ... infertility as a disease, bringing new hope for prospective parents who are challenged ... meeting to back the World Health Organization’s designation in hopes of changing the ...
(Date:6/22/2017)... Lawrence, MA (PRWEB) , ... June 22, 2017 , ... ... completed ILVO validation. The AMPH test was determined to be appropriate as a screening ... for visual interpretation, on the Charm EZ system, and the Charm EZ Lite system. ...
(Date:6/20/2017)... ... June 20, 2017 , ... National ... well-versed leader with extensive assay development and biomarker expertise, as VP of Scientific ... Boston CRO specializing in bio-analytical assay development and sample testing services. The organization ...
(Date:6/19/2017)... ... June 19, 2017 , ... Tunnell Consulting has been solving the ... the biggest challenges faced by life sciences, biotech and pharmaceuticals companies today is in ... Kati Abraham , who is well known in the industry and brings significant high-level ...
Breaking Biology Technology:
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
(Date:4/5/2017)... -- Today HYPR Corp. , leading innovator in ... the HYPR platform is officially FIDO® Certified . ... that empowers biometric authentication across Fortune 500 enterprises and ... 15 million users across the financial services industry, however ... suites and physical access represent a growing portion of ...
(Date:4/3/2017)... 3, 2017  Data captured by IsoCode, ... detected a statistically significant association between the ... treatment and objective response of cancer patients ... predict whether cancer patients will respond to ... well as to improve both pre-infusion potency testing ...
Breaking Biology News(10 mins):