Navigation Links
New silk technology preserves heat-sensitive drugs for months without refrigeration
Date:7/9/2012

MEDFORD/SOMERVILLE, Mass. (July 9, 2012, 3 PM EST) Researchers at Tufts University School of Engineering have discovered a way to maintain the potency of vaccines and other drugs -- that otherwise require refrigeration -- for months and possibly years at temperatures above 110 degrees F, by stabilizing them in a silk protein made from silkworm cocoons. Importantly, the pharmaceutical-infused silk can be made in a variety of forms such as microneedles, microvesicles and films that allow the non-refrigerated drugs to be stored and administered in a single device.

The Tufts findings address a serious obstacle to the effective use of life-saving pharmaceuticals: keeping them cold. Most vaccines, enzymes, and antibodies and many antibiotics and other drugs require constant refrigeration from manufacture to delivery to maintain their effectiveness.

International health experts estimate that nearly half of all global vaccines are lost due to breakdowns in the "cold chain." Even in industrialized nations, loss of drug efficacy at body temperature is a serious problem for advanced pharmaceutical delivery systems such as implantable drug-coated devices.

The research will be published before print in the Proceedings of the National Academy of Sciences (PNAS) Online Early Edition the week of July 9, 2012.

Tufts biomedical engineers led by David L. Kaplan, Ph.D., found that silk-stabilization preserved the efficacy of the measles, mumps and rubella (MMR) vaccine, as well as penicillin and tetracycline, at a wide range of temperatures (at least up to 60 degrees C or 140 F) significantly better than other options such as collagen encapsulants, dried powders and solutions.

"Silk protein has a unique structure and chemistry that makes it strong, resistant to moisture, stable at extreme temperatures, and biocompatible, all of which make it very useful for stabilizing antibiotics, vaccines and other drugs. The fact that we can al
'/>"/>

Contact: Kim Thurler
kim.thurler@tufts.edu
617-627-3175
Tufts University
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. University of Nottingham to play key role in European solar energy technology project
2. Two Blades Foundation licenses genome engineering technology to KWS
3. India Biotechnology in India Industry
4. Insmed Secures $20 Million Loan Agreement With Hercules Technology Growth Capital
5. Physicians Answer Questions About Food Biotechnology in IFIC Foundation Videos
6. Technology Industry Executive Joins TriCore Solutions Management Team as Executive Vice President
7. endpoint Adopts New Technology To Boast Most Robust IVR Validation Objective Evidence and Decrease IVR Build Timelines
8. Bode Technology Launches Same-Day DNA Service For Faster Response to Law Enforcement and Justice System
9. Biodetection 2012 Conference Brings Together Leading Organizations from Around the World to Address Challenges & Technology Advances in Detection and Identification of Biological Threats in Washington, DC from June 28-29, 2012
10. SEE ALGAE Technology GmbH Announces Sale of Algae Farm to Brazils Grupo JB
11. DNA Blood Test Detects Cancer Resistance Using Inostics BEAMing Technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... DALLAS , July 28, 2014 /PRNewswire/ ... research report  "Microbial Identification Market by Products (Consumables, Instruments, ... & Beverages), End User (Detection, Characterization) - ... global Microbial Identification Market is estimated at ... to reach $1,194.1 Million by 2019, growing ...
(Date:7/28/2014)... Boston, MA (PRWEB) July 28, 2014 ... with two researchers to further develop potential treatments for ... brain tumor, in combination with their patented vaccine platform, ... and Duke University, are based on the work of ... of Neurosurgery at The Preston Robert Tisch Brain Tumor ...
(Date:7/28/2014)... Appistry, Inc. , a leading provider ... of genomics to next-generation medicine, announced today its judging ... , Two Appistry staff will be joined by ... Genome Resources, and Mr. Neil Miller, director of informatics ... Rounding out the panel are Appistry’s Dr. Richard Mazzarella, ...
(Date:7/28/2014)... July 28, 2014 The global market ... by 2020, according to a new study by Grand ... rising demand for effective vaccines and drugs in an ... medical needs is expected to drive market demand over ... enhance agricultural productivity via the use of genetically engineered ...
Breaking Biology Technology:Microbial Identification Market worth $1,194.1 Million by 2019 2Microbial Identification Market worth $1,194.1 Million by 2019 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 2String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 4Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 4
... member of Congress announces that a major reason to reform the ... does it like us. , ,Even during an era when America-bashing ... well - and has always done well - much to the ... things is innovation. In fact, the United States is the greatest ...
... - TomoTherapy saw its revenues surge by ... according to the first earnings report issued since ... also announced that it has joined a research collaboration with ... lower-cost proton therapy system for cancer treatment. , , First ...
... In Part I of this series on ... of Civil Procedure, which require parties to address and ... ("ESI"). Without a plan of attack or a system ... may unnecessarily be placing your company at risk. ...
Cached Biology Technology:Changes to U.S. patent law must nurture our culture of innovation 2Changes to U.S. patent law must nurture our culture of innovation 3Changes to U.S. patent law must nurture our culture of innovation 4TomoTherapy reports 86% revenue jump, $131M net loss in Q1 2TomoTherapy reports 86% revenue jump, $131M net loss in Q1 3Finding Safe Harbor in a sea of electronic discovery 2Finding Safe Harbor in a sea of electronic discovery 3
(Date:7/28/2014)... The genome of Solanum pennellii , a wild ... an international group of researchers including the labs headed ... UC Davis Department of Plant Biology. The new genome ... , The work, published July 27 in the journal ... and colleagues at Aachen University in Germany. The UC ...
(Date:7/28/2014)... New research has identified areas of the Earth that ... climate change. , Europe is particularly vulnerable, as it ... four per cent, of any continent in ,refugia, ... natural environmental conditions remain relatively constant during times of ... Europe are mostly in Scandinavia and Scotland. , ...
(Date:7/28/2014)... YORK CITY (July 28, 2014)The Brain & Behavior ... annual Klerman and Freedman Prizes, recognizing exceptional clinical ... been supported by NARSAD Young Investigator Grants. The ... ideas in neurobiological and psychosocial research for the ... illnesses that affect one in four people. , ...
Breaking Biology News(10 mins):Study finds Europe's habitat and wildlife is vulnerable to climate change 2The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 2The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 3The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 4
... easy task to compare the environmental effects of battery ... The degree to which manufacture, usage and disposal of ... are detrimental to the environment is not exactly known. ... scientists have made a detailed life cycle assessment (LCA) ...
... world-wide collaboration of researchers has identified the first-ever genetic risk ... looked at the genetic data of more than 50,000 people, ... and they hope their research will open the door for ... that patients with a particular DNA variant on Chromosome 8 ...
... bigger hazard to the environment specifically to creatures that ... research from North Carolina State University toxicologists. In a ... One, the NC State researchers show that water fleas ... in agriculture as fertilizers and convert those chemicals into ...
Cached Biology News:'Greener' than expected 2'Greener' than expected 3First genetic link to common migraine exposed 2First genetic link to common migraine exposed 3Fertilizer chemicals linked to animal developmental woes 2
Protein Kinase D2 Immunogen: Human protein kinase D2. Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
... Upright Freezer Inventory Storage Racks ... configurations available to fit all makes ... refrigerators. Made of high quality ... 3" high fiberboard, stainless steel or ...
Many mammalian cell types and experimental situations create challenges for standard transfection experiments. The ViraPower Lentiviral Expression System overcomes these challenges with efficient vir...
Biology Products: