Navigation Links
New role for Vascular Endothelial Growth Factor in regulating skin cancer stem cells
Date:10/19/2011

Skin squamous cell carcinomas are amongst the most frequent cancers in humans. Recent studies suggest that skin squamous cell carcinoma, like many other human cancers, contain particular cancer cells, known as cancer stem cells, that present increased self-renewal potential that sustain tumor growth. Little is known about the mechanisms that regulate cancer stem cell functions.

High level of VEGF expression in skin cancer stem cells

To dissect the mechanisms that regulate cancer stem cells, the researchers determined which genes are preferentially expressed by cancer stem cell of skin tumors. They found that VEGF, a molecule known to regulate the formation of new vessels, is expressed at high level by skin cancer stem cells, which are located in close contact to the blood vessels. Administration of an antibody that decreases new blood vessel formation to mice presenting skin tumors results in a reduction of the pool of cancer stem cells leading to a reduction of the tumor size, demonstrating that vascular cells regulates skin cancer stem cell functions.

To determine whether VEGF secretion by cancer stem cells directly regulates the function of cancer stem cells, the authors genetically removed VEGF specifically in tumour cells, and found that upon VEGF ablation, skin cancer stem cells are rapidly lost due to a defect in their renewal properties, leading to tumour regression.

"It was extremely exciting to see the complete disappearance of these tumors only two weeks after the treatment" said Benjamin Beck, the first author of the Nature paper.

Critical role for Neuropilin 1, a VEGF receptor

The authors also found that Neuropilin 1, a VEGF receptor, is also highly expressed by skin cancer stem cells, and showed that Neuropilin 1 expression by cancer stem cells is critical to promote cancer stem cell renewal and tumour growth. In addition, the authors found that Neuropilin 1 is also essential for tumour formation, demonstrating the critical role of Neuropilin 1 during both cancer initiation and tumor growth.

Altogether this new study provides novel and important insights into the mechanisms by which VEGF controls tumour growth. VEGF signalling in endothelial cells is critical to sustain the formation of the vascular niche, promoting indirectly the renewal of skin cancer stem cells. VEGF secretion by cancer stem cells acts also directly on cancer stem cells by a Neuropilin 1 dependent mechanism to promote cancer stem cell renewal and tumor growth.

"Anti-VEGF therapies are currently used to treat cancers. These new results have important implications for the prevention and treatment of different epithelial cancers, as new therapies blocking VEGF and/or Neuropilin 1 functions in cancer cells may be more effective for the treatment of certain cancers compared to the therapeutic strategies blocking VEGF function only in endothelial cells" said Cdric Blanpain, the senior and corresponding author of the Nature paper.

Collaboration between Flemish and Walloon academic institutions (VIB, K.U.Leuven, UGent, ULB, FNRS, Welbio

This work is also a great example of a very effective collaboration between Walloon (ULB, FNRS, Welbio) and Flemish Universities (VIB-K.U.Leuven and VIB-UGhent).

"This collaboration nicely illustrates the great strength of a national collaboration mixing the different and unique expertises of the different Belgian groups with the same and unique goal of better understanding and treating cancer." said Peter Carmeliet (VIB-K.U.Leuven), co-author of the paper.

In conclusion, this new study, published in the online early edition of Nature, identifies a dual role for VEGF in regulating skin cancer stem cells and tumor progression.


'/>"/>

Contact: Joris Gansemans
joris.gansemans@vib.be
32-477-697-668
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Related biology technology :

1. NeoStem Acquires Amorcyte, a Clinical Stage Cardiovascular Disease Cell Therapy Company
2. Effient® (Prasugrel) Showed Significant 26 Percent Reduction in Cardiovascular Events Over Clopidogrel in New Core Clinical Cohort Population Sub-Analysis of the TRITON-TIMI 38 Pivotal Study
3. Creating a Road Map for Successful Cardiovascular New Product Launch
4. Pediatrics Study Finds Children Taking ADHD Medications Did Not Suffer More Serious Heart Problems or Cardiovascular-related Death
5. SpectraCell Now Offers LPP™ Cardiovascular Testing in New York
6. Harvest Technologies Announces Initial Enrollment in Its REVIVE-1 Trial (REtrograde Vascular Infusion of BMAC to ImproVe Heart FailurE)
7. New CDC Guidelines for Prevention of Intravascular Catheter-Associated Infections Designate Chlorhexidine Gluconate-Impregnated Sponge as a Category 1B Recommendation Exclusively Based on Evidence Related to BIOPATCH® Protective Disk With CHG
8. Significant Reduction in Pain With the Mynx Vascular Closure Device Versus Angio-Seal Device
9. Study Shows Cardiovascular Deaths in Europe Could Be Prevented
10. Elsevier Announces New Partnership With Canadian Cardiovascular Society to Publish the Canadian Journal of Cardiology
11. Stryker Announces Definitive Agreement to Acquire the Neurovascular Division of Boston Scientific for $1.5 Billion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... Meister ... mind, the fresh look and added functionality give the agricultural world a taste ... a dynamic shift in agriculture – from precision farming via satellites and Unmanned ...
(Date:5/2/2016)... ... May 02, 2016 , ... F.E.E.D. Co., the Feline ... their revolutionary, veterinarian-designed product for indoor cats. The NoBowl Feeding System replaces the ... food the way nature intended. NoBowls make cats happy and healthy. , Since ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... in personalized pain medicine, is excited to announce the launch of the ... public health studies, volunteerism, and education to promote the use of personalized medicine ...
(Date:4/29/2016)... ALBANY, New York , April 29, 2016 ... market report published by Transparency Market Research "Separation ... Analysis, Size, Share, Growth, Trends, and Forecast 2015 ... market was valued at US$ 10,665.5 Mn in ... CAGR of 6.8% from 2015 to 2023 to ...
Breaking Biology Technology:
(Date:4/26/2016)... -- Research and Markets has announced the ...  report to their offering.  , ,     (Logo: ... forecast the global multimodal biometrics market to grow ... 2016-2020.  Multimodal biometrics is being implemented ... healthcare, BFSI, transportation, automotive, and government for controlling ...
(Date:4/13/2016)... April 13, 2016  IMPOWER physicians supporting Medicaid patients ... a new clinical standard in telehealth thanks to a ... the higi platform, IMPOWER patients can routinely track key ... body mass index, and, when they opt in, share ... visit to a local retail location at no cost. ...
(Date:3/22/2016)... PUNE, India , March 22, 2016 ... new market research report "Electronic Sensors Market for ... Fingerprint, Proximity, & Others), Application (Communication & ... and Geography - Global Forecast to 2022", ... consumer industry is expected to reach USD ...
Breaking Biology News(10 mins):