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New nanomedicine resolves inflammation, promotes tissue healing
Date:3/19/2013

gnaling molecules that can lead to a constant hyper-inflammatory state and further disease complications."

"The beauty of this approach is that, unlike many other anti-inflammatory approaches, it takes advantage of nature's own design for preventing inflammation-induced damage, which does not compromise host defense and promotes tissue repair," said Dr. Tabas.

While the nanoparticles do spread to tissues throughout the body, they tend to concentrate in areas of inflammation. "In theory, this should allow physicians to use smaller-than-usual doses of medications and reduce unwanted side effects," said Dr. Fredman.

The team is currently designing nanoparticles for the treatment of atherosclerosis. Preliminary studies show that the nanoparticles are capable of targeting atherosclerotic plaques.

The authors have filed a patent for targeted polymeric inflammation-resolving nanoparticles to treat a variety of chronic inflammatory diseases, including atherosclerosis, autoimmune disease, type 2 diabetes, and Alzheimer's disease.


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Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3

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