Navigation Links
New models predict where E. coli strains will thrive
Date:11/18/2013

Bioengineers at the University of California, San Diego have used the genomic sequences of 55 E. coli strains to reconstruct the metabolic repertoire for each strain. Surprisingly, these reconstructions do an excellent job of predicting the kind of environment where each strain will thrive, the researchers found.

Their analysis, published in the Nov. 18, 2013 early edition of the Proceedings of the National Academy of Sciences, could prove useful in developing ways to control deadly E. coli infections and to learn more about how certain strains of the bacteria become virulent.

And when "nasty new versions" of E. coli appear, the metabolic models may someday help researchers quickly identify and characterize these new strains, said Bernhard Palsson, professor of bioengineering at UC San Diego Jacobs School of Engineering and a corresponding author on the paper.

The reconstructions map out all the genes, reactions and products of metabolism for each strain and allow the researchers to probe their coordinated functionality. Each strain's metabolic capabilities, the researchers discovered, correspond to specific environmental niches. Commensal or "friendly" E. coli strains also can be distinguished from pathogenic strains using this technique.

"This paper shows that you can predict the microenvironmental niche where human pathogenic strains of E. coli grow, whether it's in your bladder or your stomach, or your blood or elsewhere, based on these sequences," Palsson said.

Jonathan Monk, a nanoengineering graduate student in the Jacobs School of Engineering and lead author of the paper, said that the metabolic reconstructions might also help researchers figure out ways to deprive pathogenic E. coli of the nutrients they need, "so that you can prevent them from getting an advantage in that niche, and maybe better control an infection that way."

The first E. coli strain was sequenced 15 year
'/>"/>

Contact: Daniel Kane
dbkkane@eng.ucsd.edu
858-534-3262
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related biology technology :

1. HemoShear to Develop Human Cancer Models to Improve Industry Success Rates in New Anticancer Drug Development
2. New Advances and Opportunities in Managing Pain: Translational Animal Models, New Webinar Hosted by Xtalks
3. Cellular Dynamics International Expands MyCell Products Line with Disease Models, Genetic Engineering Patents
4. Advancing Preclinical Predictions, Making Faster Clinical Decisions with Cancer Models and Preclinical Imaging - World Pharma Congress this June in Philadelphia
5. University of Colorado Cancer Center Study Shows that Bitter Melon Juice Prevents Pancreatic Cancer in Mouse Models
6. GNS Healthcare Joins Orion Bionetworks to Develop Predictive Models for Multiple Sclerosis and Other Diseases
7. Organovo Partners With ZenBio to Create 3D Tissue Models
8. Karyopharm Therapeutics Announces Oral Presentation at the American College of Rheumatology (ACR) on the use of Selective Inhibitors of Nuclear Export (SINE) CRM1 Antagonists in preclinical models of Systemic Lupus Erythematosus (SLE)
9. Harvards Wyss Institute models a human disease in an organ-on-a-chip
10. Isis And Collaborators Alleviate Disease In Animal Models Of Myotonic Dystrophy
11. A new imaging system produces 3-D models of monuments using unmanned aircraft
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... Specialty Pharmacy Times has completed its ... BPA Worldwide as a business publication member. As ... for Specialty Pharmacy Times based on business/distribution, demographics ... member of BPA Worldwide, Specialty Pharmacy Times shows ... the most reliable, unequaled data,” said Chris Hennessy, ...
(Date:5/21/2015)... 21, 2015 Imagine being able ... and those of others. Being able to read faces ... read people to anticipate their thoughts and actions like ... and feelings to create unique abstract paintings and video, ... Get inside a first-person-shooter as it creates action, dialog, ...
(Date:5/21/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/84975r/2015_global ) ... Global Survey on Flow Cytometry Adoption Trends" ... goal of this research is to analyze the ... information the survey seeks to collect include factors ... used applications for flow cytometers, respondents, most preferred ...
(Date:5/20/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/x4b7kw/top_technologies ... Technologies in HW_Technical Insights" report to their offering. ... technology trends in the Health and Wellness sector and ... have an impact in the year 2015. The research ... 10 health and wellness technologies that are anticipated to ...
Breaking Biology Technology:Specialty Pharmacy Times Joins BPA Worldwide 25 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2Global Survey on Flow Cytometry Adoption Trends 2015 2Top Technologies in the Health and Wellness Industry 2015 2
... and Preclinical-Stage Compounds ... in Merck KGaA ... drug discovery and development company, announced today that,it will collaborate ... discover new applications for drug candidates. KineMed,s,proprietary pathway-based drug discovery ...
... CHELMSFORD, Mass., Aug. 28 Magellan Biosciences, ... that,Steven E. Diamond, PhD, has joined the ... to Magellan from Siemens Medical Solutions Diagnostics,(formerly ... research and,development, for the point-of-care product lines: ...
... Laboratories, a national,clinical and anatomic pathology reference laboratory ... announced today that it has,renewed a multisource group ... the nation,s largest purchasing alliances of leading,hospitals and ... between ARUP and Premier which has been in ...
Cached Biology Technology:KineMed to Collaborate With Merck KgaA to Validate New Applications for Drug Development Candidates 2Magellan Biosciences Names Steven E. Diamond, PhD, Chief Scientific Officer 2Magellan Biosciences Names Steven E. Diamond, PhD, Chief Scientific Officer 3ARUP Laboratories and Premier Extend Contract for Reference Laboratory Testing Services 2
(Date:4/14/2015)... NEW YORK , April 14, 2015 /PRNewswire/ ... Fast IDentity Online (FIDO ® ) Alliance tm ... standards-based specifications. FIDO members commit to share technology ... authentication methods that are interoperable, more secure and ... specifications enable biometric identity verification that protects sensitive ...
(Date:4/13/2015)... April 13, 2015  higi, a leading cloud-based consumer ... more fully engage with their communities around health and ... protected and secure API.  ... most accessible, affordable, and convenient vehicle to receive validated ... The API will allow higi,s trusted ...
(Date:4/8/2015)... , April 8, 2015  Infinisource, a ... and services, and Morpho, a leading supplier of ... to produce the market,s most advanced biometrically-enabled time ... iSolved NXG time clock is setting a bold, ... labor data for the small and mid-size employer. ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... abuzz after using fruit flies to find new ways ... cellsresults that could one day be used to advance ... that caffeine interferes with processes in cancer cells that ... in using the stimulant as a chemotherapy treatment. But ...
... fish, with an intriguing past, now has had its ... genetic changes that accompanied the adaptation from an aquatic ... by Chris Amemiya, PhD, Director of Molecular Genetics at ... Professor of Biology at the University of Washington, will ...
... to ward off viruses by activating a naturally occurring protein ... disrupts the levels of cholesterol required in cell membranes to ... in molecular microbiology and immunology at the Keck School of ... to fight a variety of viral infections. "Previous studies ...
Cached Biology News:Genome sequencing of the living coelacanth sheds light on the evolution of land vertebrate 2Genome sequencing of the living coelacanth sheds light on the evolution of land vertebrate 3University of Southern California scientists reveal natural process that blocks viruses 2
MOUSE ANTI GUINEA PIG T-CELLS (PAN):FITC Immunogen: Guinea pig peritoneal T-cells...
MOUSE ANTI RABBIT T LYMPHOCTYES Immunogen: Rabbit Thymocytes...
Normal canine serum collected from healthy normal canines....
RABBIT ANTI HUMAN CYTOCHROME P450 1A1/2 Immunogen: Purified human CYP1A2 expressed in E.Coli ...
Biology Products: